Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. Used as chlorpromazine hydrochloride and sold under the tradenames Largactil® and Thorazine®, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects. It has also anxiolytic (alleviation of anxiety) properties. Today, chlorpromazine is considered a typical antipsychotic.

Chemistry

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Chlorpromazine is derived from phenothiazine, and has an aliphatic side chain, typical for low to middle potency neuroleptics. The oral bioavailability is estimated to be 30% to 50% due to extensive first pass metabolization in the liver. Its elimination-halflife is 16 to 30 hours. It has many active metabolites (approx. 75 different ones) with greatly varying halflives and own pharmacological profiles. The CYP-450 isoenzymes 1A2 and 2D6 are needed for metabolization of chlorpromazine and the subtype 2D6 is inhibited by chlorpromazine (NB: possible interactions with other drugs).

Mechanism of action

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Chlorpromazine. Please.
jcarlo (Carlo M) Fri, 18 Dec 2009 12:06:41 -0000
Chlorpromazine. Please.
@Jez_Horrox There is a new drug they are thinking of trying - a new variant of Chlorpromazine..but I have tried literally everything else.
dottymummy (Dotty Finlow) Wed, 16 Dec 2009 10:35:41 -0000
@Jez_Horrox There is a new drug they are thinking of trying - a new variant of Chlorpromazine..but I have tried literally everything else.
" The pill in description is Chlorpromazine (50 mg). To view information about this drug, please click on th http://PD0.US/R183840
druginfo (Medicine Community) Sat, 12 Dec 2009 18:30:11 -0000
" The pill in description is Chlorpromazine (50 mg). To view information about this drug, please click on th http://PD0.US/R183840

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