Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. Used as chlorpromazine hydrochloride and sold under the tradenames Largactil® and Thorazine®, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects. It has also anxiolytic (alleviation of anxiety) properties. Today, chlorpromazine is considered a typical antipsychotic.

Chemistry

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Chlorpromazine is derived from phenothiazine, and has an aliphatic side chain, typical for low to middle potency neuroleptics. The oral bioavailability is estimated to be 30% to 50% due to extensive first pass metabolization in the liver. Its elimination-halflife is 16 to 30 hours. It has many active metabolites (approx. 75 different ones) with greatly varying halflives and own pharmacological profiles. The CYP-450 isoenzymes 1A2 and 2D6 are needed for metabolization of chlorpromazine and the subtype 2D6 is inhibited by chlorpromazine (NB: possible interactions with other drugs).

Mechanism of action

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Central

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@cyndaelle (phenothiazines such as chlorpromazine or fluphenazine) prozac is Fluoxetine
CrimsonEtClover (Cherub Freed) Fri, 06 Nov 2009 19:53:36 -0000
@cyndaelle (phenothiazines such as chlorpromazine or fluphenazine) prozac is Fluoxetine
Tonight was great, had to dig out my chlorpromazine when i got home though haha! @Beesoooon HAPPY BIRTHDAY!!!
donnnax (Donna Newman) Fri, 30 Oct 2009 23:39:31 -0000
Tonight was great, had to dig out my chlorpromazine when i got home though haha! @Beesoooon HAPPY BIRTHDAY!!!

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