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Chlorambucil (marketed as Leukeran by GlaxoSmithKline) is a chemotherapy drug that has been mainly used in the treatment of chronic lymphocytic leukemia. It is a nitrogen mustard alkylating agent and can be given orally.
In the past, it has been used for treating some types of non-Hodgkin lymphoma, Waldenström macroglobulinemia, polycythemia vera, trophoblastic neoplasms, ovarian carcinoma. It also has been used as an immunosuppressive drug for various autoimmune and inflammatory conditions, e.g. nephrotic syndrome. Its current use is mainly for CLL as it is well tolerated by most patients, though this has been primarily replaced by fludarabine.
Side Effects
Myelosuppression (anemia, neutropenia, thrombocytopenia), or bone marrow suppression is the most commonly occurring side effect of Chlorambucil. Withdrawn from the drug, this side effect may be reversible, but bone marrow failure can occur in rare cases. More on [ Chlorambucil ]
Fludarabine Provides OS Advantage vs Chlorambucil in Previously Untreated CLL http://bit.ly/5LgDhj
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Fludarabine Provides OS Advantage vs Chlorambucil in Previously Untreated CLL http://bit.ly/5LgDhj
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Leukeran - Product information on the cancer drug chlorambucil, from GlaxoSmithKline. [PDF]
MedlinePlus: Chlorambucil - Provides information on usage, precautions, side effects and brand names when available. Data provided by various government agencies and health-related organizations.
Meta Description: [ Chlorambucil ]
