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Celecoxib (INN) (IPA: ) is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis. It is marketed by Pfizer under the brand name Celebrex.
Pharmacology
Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits this isoform of cyclooxygenase, whereas traditional NSAIDs inhibit both COX-1 and COX-2. Celecoxib is approximately 10-20 times more selective for COX-2 inhibition over COX-1. In theory, this specificity allows celecoxib and other COX-2 inhibitors to reduce inflammation (and pain) while minimizing gastrointestinal adverse drug reactions (e.g. stomach ulcers) that are common with non-selective NSAIDs. It also means that it has a reduced effect on platelet aggregation compared to traditional NSAIDs.
Adverse effects
Main article: Non-steroidal anti-inflammatory drug More on [ Celecoxib ]
Analgesics and Anti Inflammatories :: Drugs and Medications
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Celebrex - A source of information about relief from arthritis pain including Osteoarthritis and Rheumatoid Arthritis. A nonsteroidal anti-inflammatory drug, product information is provided.
Celebrex - Full prescribing information from RxList.
Meta Description: [ Information on Celebrex Oral(Celebrex) - Patient Handout. Find the answers you need about over the counter and prescription medications, vitamins and supplements, and much more. ]
DrugDigest: Celecoxib ( Celebrex ) - Information on dosage, usage, side effects, interactions, and drug comparisons.
Food and Drug Administration (FDA) - Celebrex Consumer Information - Patient FAQ in html format with a link to approved labeling (as pdf).
MedlinePlus: Celecoxib - Provides information on usage, precautions, side effects and brand names when available. Data provided by various government agencies and health-related organizations.
Meta Description: [ Celecoxib ]
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