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Carvedilol is a non-selective beta blocker indicated in the treatment of mild to moderate congestive heart failure (CHF). It is marketed under various trade names including Coreg (GSK), Dilatrend (Roche) and Eucardic (Roche).
Pharmacology
In addition to blocking both β1- and β2-adrenergic receptors, carvedilol also displays α1-adrenergic antagonism as well, which confers the added benefit of reducing blood pressure through vasodilation.
Relative to other beta blockers, carvedilol has minimal inverse agonist activity (Vanderhoff et al., 1998). This suggests that carvedilol has a reduced negative chronotropic and inotropic effect compared to other beta blockers, which may decrease its potential to worsen symptoms of heart failure.
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Coreg - GSK - Includes information for patients and families about heart failure diagnosis, treatment, healthy food choices, lifestyle and prescribing information.
Meta Description: [ Information on COREG and treatment of high blood pressure, at COREG.com ]
MedlinePlus: Carvedilol - Provides information on usage, precautions, side effects and brand names when available. Data provided by various government agencies and health-related organizations.
Meta Description: [ Carvedilol ]
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