Carboplatin is a chemotherapy drug used against some forms of cancer. It was introduced in the late 1980s and has since gained popularity in clinical treatment due to its vastly reduced side-effects compared to its parent compound cisplatin. Cisplatin and carboplatin, as well as oxaliplatin, are classified as DNA alkylating agents.

History

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Bristol-Myers Squibb gained Food and Drug Administration (FDA) approval for carboplatin, under the brand name Paraplatin, in March 1989. The drug went generic in October 2004. There are also generic versions of the drug available from APP, Bedford, Sicor, Mayne Pharma, Pharmachemie, Pliva, Sandoz, Spectrum.

Pharmacology

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Chemistry

Carboplatin differs from cisplatin in that it has a closed cyclobutane dicarboxylate (CBDCA) moiety on its leaving arm in contrast to the readily leaving chloro groups. This results in very different DNA binding kinetics, though it forms the same reaction products in vitro at equivalent doses with cisplatin. However, recent studies provide a new caveat on the DNA binding molecular mechanisms with the possibility of being activated by nucleophiles (as opposed to cisplatin), before forming the toxic adducts. There are also results to show that cisplatin and carboplatin cause different morphological changes in MCF-7 cell lines while exerting their cytotoxic behaviour.

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erlotinib w/ or w/o carboplatin & paclitaxel in treating ppl w/ stage iiib or stage iv non-small cell lung cancer http://bit.ly/5pSOOf
recruitingtrial (Recruiting Trials) Sat, 05 Dec 2009 00:50:37 -0000
erlotinib w/ or w/o carboplatin & paclitaxel in treating ppl w/ stage iiib or stage iv non-small cell lung cancer http://bit.ly/5pSOOf
carboplatin, paclitaxel, bvacizumab, & abt-888 in treating ppl w/ newly diagnosed stage ii, stage iii, or stage iv http://bit.ly/6W1wAK
localtrials (US Clinical Trials ) Sat, 05 Dec 2009 00:06:42 -0000
carboplatin, paclitaxel, bvacizumab, & abt-888 in treating ppl w/ newly diagnosed stage ii, stage iii, or stage iv http://bit.ly/6W1wAK
carboplatin, paclitaxel, bvacizumab, & abt-888 in treating ppl w/ newly diagnosed stage ii, stage iii, or stage iv http://bit.ly/6W1wAK
usclinicaltrial (US Clinical Trials) Fri, 04 Dec 2009 23:58:42 -0000
carboplatin, paclitaxel, bvacizumab, & abt-888 in treating ppl w/ newly diagnosed stage ii, stage iii, or stage iv http://bit.ly/6W1wAK
phase i bms-690514 in combo w/ paclitaxel & carboplatin http://bit.ly/5XT7qC
localtrials (US Clinical Trials ) Fri, 04 Dec 2009 21:22:47 -0000
phase i bms-690514 in combo w/ paclitaxel & carboplatin http://bit.ly/5XT7qC
phase i bms-690514 in combo w/ paclitaxel & carboplatin http://bit.ly/5XT7qC
usclinicaltrial (US Clinical Trials) Fri, 04 Dec 2009 21:14:45 -0000
phase i bms-690514 in combo w/ paclitaxel & carboplatin http://bit.ly/5XT7qC
phase ii paclitaxel & carboplatin in ppl w/ elev8d-risk cancer of uterus http://bit.ly/4Do81h
cancertrials_ (Cancer Trials) Fri, 04 Dec 2009 20:22:47 -0000
phase ii paclitaxel & carboplatin in ppl w/ elev8d-risk cancer of uterus http://bit.ly/4Do81h

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