Carboplatin is a chemotherapy drug used against some forms of cancer. It was introduced in the late 1980s and has since gained popularity in clinical treatment due to its vastly reduced side-effects compared to its parent compound cisplatin. Cisplatin and carboplatin, as well as oxaliplatin, are classified as DNA alkylating agents.

History

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Bristol-Myers Squibb gained Food and Drug Administration (FDA) approval for carboplatin, under the brand name Paraplatin, in March 1989. The drug went generic in October 2004. There are also generic versions of the drug available from APP, Bedford, Sicor, Mayne Pharma, Pharmachemie, Pliva, Sandoz, Spectrum.

Pharmacology

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Chemistry

Carboplatin differs from cisplatin in that it has a closed cyclobutane dicarboxylate (CBDCA) moiety on its leaving arm in contrast to the readily leaving chloro groups. This results in very different DNA binding kinetics, though it forms the same reaction products in vitro at equivalent doses with cisplatin. However, recent studies provide a new caveat on the DNA binding molecular mechanisms with the possibility of being activated by nucleophiles (as opposed to cisplatin), before forming the toxic adducts. There are also results to show that cisplatin and carboplatin cause different morphological changes in MCF-7 cell lines while exerting their cytotoxic behaviour.

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Carboplatin - Twitter Search

Study of Sequential Topoisomerase, Irinotecan/Oxaliplatin – Etoposide /Carboplatin in Extensive SCLC http://t.co/5dtraIpy
clinicaltrialsn (Clinical Trials) Thu, 26 Jan 2012 05:57:31 -0000
Study of Sequential Topoisomerase, Irinotecan/Oxaliplatin – Etoposide /Carboplatin in Extensive SCLC http://t.co/5dtraIpy
A Phase I/Randomized Phase II Trial of Everolimus and Bevacizumab Combined with Either Temozolomide or Carboplatin… http://t.co/Mf5Mdveb
AZCSDB (AZCS(CRU)) Thu, 26 Jan 2012 04:34:57 -0000
A Phase I/Randomized Phase II Trial of Everolimus and Bevacizumab Combined with Either Temozolomide or Carboplatin… http://t.co/Mf5Mdveb
Most Popular: Weekly Paclitaxel and Carboplatin Induction Chemotherapy Followed by Concurrent Chemoradiotherapy ... http://t.co/PB6hoRUP
AJCOonline (Wolters Kluwer LWW) Wed, 25 Jan 2012 18:25:56 -0000
Most Popular: Weekly Paclitaxel and Carboplatin Induction Chemotherapy Followed by Concurrent Chemoradiotherapy ... http://t.co/PB6hoRUP
Comparative effectiveness of cisplatin-based and carboplatin-based chemotherapy for treatment of advanced urothelial... http://t.co/2cIAYYZD
Life_Sciences_ (Life Sciences) Wed, 25 Jan 2012 16:04:08 -0000
Comparative effectiveness of cisplatin-based and carboplatin-based chemotherapy for treatment of advanced urothelial... http://t.co/2cIAYYZD
Randomized Phase III Study of Thoracic Radiation in Combination With Paclitaxel and Carboplatin ... http://t.co/dB44zlxX #ThoracicCancer
TheSmartestOnc (TheSmartestOnc) Wed, 25 Jan 2012 11:44:53 -0000
Randomized Phase III Study of Thoracic Radiation in Combination With Paclitaxel and Carboplatin ... http://t.co/dB44zlxX #ThoracicCancer
RT @InorganicNews: [ICA] Understanding How the Platinum Anticancer Drug Carboplatin Works: From the Bottle to the Cell http://t.co/dbfW5y8Y
kasami_open (傘美) Wed, 25 Jan 2012 08:31:07 -0000
RT @InorganicNews: [ICA] Understanding How the Platinum Anticancer Drug Carboplatin Works: From the Bottle to the Cell http://t.co/dbfW5y8Y

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