Carbamazepine and its derivatives' mechanism of action is relatively well understood. Voltage gated sodium channels are the molecular pores that allow brain cells (neurons) to generate action potentials, the electrical event that allows neurons to communicate over long distances. After the sodium channels open, to start the action potential, they inactivate, essentially closing the channel. Carbamazepine stabilizes the inactivated state of sodium channels, meaning that fewer sodium channels are available to open, making brain cells less excitable.
Carbamazepine (Tegretol, Epitol) Information - Information on the pharmacology, contra-indications, dosages and side effects of this common drug treatment for neuralgia, from mentalhealth.com.
MedlinePlus: Carbamazepine - Provides information on usage, precautions, side effects and brand names when available. Data provided by various government agencies and health-related organizations.
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