Carbamazepine (sold under the brand-names Biston, Calepsin, Carbatrol, Epitol, Equetro, Finlepsin, Sirtal, Stazepine, Tegretol, Telesmin, Timonil) is an anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy and bipolar disorder. It is also used to treat schizophrenia and trigeminal neuralgia.

Mechanisms

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Carbamazepine and its derivatives' mechanism of action is relatively well understood. Voltage gated sodium channels are the molecular pores that allow brain cells (neurons) to generate action potentials, the electrical event that allows neurons to communicate over long distances. After the sodium channels open, to start the action potential, they inactivate, essentially closing the channel. Carbamazepine stabilizes the inactivated state of sodium channels, meaning that fewer sodium channels are available to open, making brain cells less excitable.

Side effects

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Carbamazepine renders birth control pills ineffective because it lowers the level of estrogen produced by them.

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#toxicology Teratogenic effects of carbamazepine on embryonic eye development in pregnant mice: Cuta.. http://bit.ly/2My5nd
Toxicology_IPS (Toxicology Research) Fri, 06 Nov 2009 18:24:56 -0000
#toxicology Teratogenic effects of carbamazepine on embryonic eye development in pregnant mice: Cuta.. http://bit.ly/2My5nd
Chlorpromazide, carbamazepine, cyclophosphamide, vincristine, phenothiazines can cause Syndrome of Inappropriate ADH secretion.
justanotherdoc (A Med Student) Wed, 04 Nov 2009 06:22:05 -0000
Chlorpromazide, carbamazepine, cyclophosphamide, vincristine, phenothiazines can cause Syndrome of Inappropriate ADH secretion.

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