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Carbachol (Kar-ba-kol English phonetic spelling]), also known as carbamylcholine (marketed under the brand names Carbastat®, Carboptic®, Isopto Carbachol®, Miostat®), is classified as a cholinergic. It is primarily used for various opthalmic purposes, such as for treating glaucoma, or for use during ophthalmic surgery. It is generally administered as an intraocular solution (i.e. eyedrop).

Chemistry and pharmacology


Carbachol is a choline ester and a positively charged quaternary ammonium compound. It is not well absorbed in the gastro-intestinal tract and does not cross the blood-brain barrier. It is usually administered topical ocular or through intraocular injection. Carbachol is not easily metabolized by cholinesterase, its duration of action is 4 to 8 hours with topical administration and 24 hours for intraocular administration. Since carbachol is poorly absorbed through topical administration, benzalkonium chloride is mixed in to promote absorption.

Carbachol is a parasympathomimetic that stimulates both muscarinic and nicotinic receptors. In topical ocular and intraocular administration its principal effects are miosis and increased aqueous humour outflow.

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Negative regulation of endogenous protein kinase Calpha on the dynamic change of carbachol-induced intracellular... - http://bit.ly/7LXBIw
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Negative regulation of endogenous protein kinase Calpha on the dynamic change of carbachol-induced intracellular... - http://bit.ly/7LXBIw

 
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MedlinePlus: Carbachol (Ophthalmic) - Provides information on usage, precautions, side effects and brand names when available. Data provided by various government agencies and health-related organizations.
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