Calcitonin is a 32 amino acid polypeptide hormone that is produced in humans primarily by the C cells of the thyroid, and in many other animals in the ultimobranchial body.

Synthesis

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It is formed by proteolytic cleavage of a larger prepropeptide which is the product of the CALC1 gene, which itself is part of a superfamily of related protein hormone precusors including Islet Amyloid Precursor Protein, Calcitonin Gene-Related Peptide and the precursor of Adrenomedullin.

Physiology

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The hormone participates in calcium and phosphorus metabolism and it was found in fish, reptiles, birds and mammals. Most evidence indicates that calcitonin is of very little physiological importance to humans. Rather, calcium and phosphate homeostasis is primarily under the control of parathyroid hormone (PTH).

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strawbEriine (Joverine Salamanca) Tue, 07 Feb 2012 16:52:06 -0000
Calcitonin kasi.
The calcitonin gene-related peptide family: form, function and future perspectives: This book contains a compreh... http://t.co/jT15otnZ
Miarfp (Mia Prue) Tue, 07 Feb 2012 12:05:42 -0000
The calcitonin gene-related peptide family: form, function and future perspectives: This book contains a compreh... http://t.co/jT15otnZ
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