Bupropion (amfebutamone) (brand names Wellbutrin and Zyban) is an antidepressant of the aminoketone class, chemically unrelated to tricyclics or selective serotonin reuptake inhibitors (SSRIs). It is similar in structure to the stimulant cathinone, and to phenethylamines in general. It is a chemical derivative of diethylpropion, an amphetamine-like substance used as an anorectic. Bupropion is both a dopamine reuptake inhibitor and a norepinephrine reuptake inhibitor. It is often used as a smoking cessation aid.

History

---

Bupropion was first synthesized by Burroughs Research in 1966, and patented by Burroughs-Wellcome (later Glaxo-Wellcome, and, as of 2000, GlaxoSmithKline) in 1974. It was approved by the Food and Drug Administration (FDA) as an antidepressant in 1989 and marketed under the name Wellbutrin, but clinical trials indicated that incidence of seizure was two to four times greater than other antidepressants and the drug was quickly pulled from the market. It was subsequently discovered that reducing the dose by about half greatly reduced the risk of seizures.

Glaxo then developed a sustained-release (SR) version of Wellbutrin which releases bupropion at a slower rate. The SR formulation is taken twice a day, in order to further decrease the possibility of adverse side effects and seizures. It is also available in generic form (Bupropion SR). Extended Release bupropion, Wellbutrin XL, is the most recent formulation of bupropion and is taken orally once a day. With this altered mechanism of delivery and reduced dosing, incidence of seizures is comparable to, and in some cases lower than, that of other antidepressants. Patients using Bupropion should still be checked for pre-disposing factors that might lead to a lower than normal seizure threshold. It is also important to check for other medications the patient might be using which might also work to lower the seizure threshold.

More on [ Bupropion ]

Bupropion - Twitter Search

Bupropion Mexico : The Best Online Pharmacy Sites on the Internet. No Prior Prescription!.Legal Pharmacy. Guara.. http://bit.ly/3zmZzR
ObamaCareBlog (ObamaCareBlog.com) Sun, 08 Nov 2009 05:01:09 -0000
Bupropion Mexico : The Best Online Pharmacy Sites on the Internet. No Prior Prescription!.Legal Pharmacy. Guara.. http://bit.ly/3zmZzR
Zyban Sr without prescription - hydrochloride, contains the active ingredient bupropion, a lo.. http://bit.ly/2htH2h check my homepage
fitforlife101 (Acai Lover) Sun, 08 Nov 2009 00:25:19 -0000
Zyban Sr without prescription - hydrochloride, contains the active ingredient bupropion, a lo.. http://bit.ly/2htH2h check my homepage
is having massive mood swings today, cried for hours again! GP 2day prob be told to wait for hospital on 17th just gimme damn bupropion!!
PoisonGirlSasa (Sarah White) Fri, 06 Nov 2009 05:12:13 -0000
is having massive mood swings today, cried for hours again! GP 2day prob be told to wait for hospital on 17th just gimme damn bupropion!!
Both varenicline and bupropion have been associated with suicidal ideation in patients who had no psychiatric history http://bit.ly/15lvs9
DrVes (Ves Dimov, M.D.) Thu, 05 Nov 2009 14:58:05 -0000
Both varenicline and bupropion have been associated with suicidal ideation in patients who had no psychiatric history http://bit.ly/15lvs9
RT @shawncmason The Assessment Of Reactions To Bupropion Use Is Difficult Because ….. http://bit.ly/1uplgx Plz RT
finallyfeelgood (Shawn Mason) Wed, 04 Nov 2009 09:35:46 -0000
RT @shawncmason The Assessment Of Reactions To Bupropion Use Is Difficult Because ….. http://bit.ly/1uplgx Plz RT
Erowid Experience Vaults: Mushrooms, Wellbutrin XL (Bupropion... http://tinyurl.com/yzmp3sj
terraiqfti (Terra Hopkins) Wed, 04 Nov 2009 03:51:05 -0000
Erowid Experience Vaults: Mushrooms, Wellbutrin XL (Bupropion... http://tinyurl.com/yzmp3sj

Subscribe to Bupropion RSS feed