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Bortezomib (marketed as Velcade™ by Millennium Pharmaceuticals) is a "first-in-class" proteasome inhibitor. It is the best studied of a next generation of anti-myeloma drugs, and is also a potential treatment for plasma cell leukemia.
Bortezomib works by blocking the action of 26S proteasome, which is a multicatalytic enzyme whose function is to degrade abnormal or misfolded proteins targeted for destruction. There is emerging evidence that 26S proteasome plays a role in myeloma and lymphoma.
The Multiple Myeloma Research Foundation was responsible for a substantial amount of the funding for the development and testing of this drug.
More on [ Bortezomib ]
Check out Med-Chemist: Bortezomib for bone cancer in children & teens.. at http://bit.ly/1r717V
Med_chemist (Umesh) Fri, 06 Nov 2009 07:03:57 -0000
Check out Med-Chemist: Bortezomib for bone cancer in children & teens.. at http://bit.ly/1r717V
Cancer News Bortezomib lymphoma drug may be effective against bone cancer in children and teens: Stu.. http://bit.ly/28Lpqb
CancerNewsNet (News-Medical.Net) Fri, 06 Nov 2009 05:16:58 -0000
Cancer News Bortezomib lymphoma drug may be effective against bone cancer in children and teens: Stu.. http://bit.ly/28Lpqb
Bortezomib lymphoma drug may be effective against bone cancer in child http://bit.ly/16UXzC
letreset (letreset) Fri, 06 Nov 2009 05:00:06 -0000
Bortezomib lymphoma drug may be effective against bone cancer in child http://bit.ly/16UXzC
Bortezomib lymphoma drug may be effective against bone cancer in children and teens: Study: A drug already appr.. http://bit.ly/28Lpqb
w23peace (Alinda K. Williams) Fri, 06 Nov 2009 04:54:38 -0000
Bortezomib lymphoma drug may be effective against bone cancer in children and teens: Study: A drug already appr.. http://bit.ly/28Lpqb
Bortezomib shows promise in early tests against bone cancer ... http://bit.ly/4ngh64
knowdrugs (Sunil) Thu, 05 Nov 2009 20:28:54 -0000
Bortezomib shows promise in early tests against bone cancer ... http://bit.ly/4ngh64
Bortezomib + MEL 200 como condicionamento do TAMO em MM: pelo menos 70% de VGPR. Roussel M et al. Blood 2 nov 2009.
doyle66 (rodrigo doyle ) Wed, 04 Nov 2009 12:28:22 -0000
Bortezomib + MEL 200 como condicionamento do TAMO em MM: pelo menos 70% de VGPR. Roussel M et al. Blood 2 nov 2009.
MedlinePlus: Bortezomib (Systemic) - Provides information on usage, precautions, side effects and brand names when available. Data provided by government agencies and health-related organizations
Meta Description: [ Bortezomib(Systemic) ]
Velcade (PS-341) - Description, mechanism of action, side effects, and other information, from the Multiple Myeloma Research Foundation.
| ASH 2006 - Dr. Dispenzieri discusses Velcade Results | |
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