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Bortezomib (marketed as Velcade™ by Millennium Pharmaceuticals) is a "first-in-class" proteasome inhibitor. It is the best studied of a next generation of anti-myeloma drugs, and is also a potential treatment for plasma cell leukemia.
Bortezomib works by blocking the action of 26S proteasome, which is a multicatalytic enzyme whose function is to degrade abnormal or misfolded proteins targeted for destruction. There is emerging evidence that 26S proteasome plays a role in myeloma and lymphoma.
The Multiple Myeloma Research Foundation was responsible for a substantial amount of the funding for the development and testing of this drug.
More on [ Bortezomib ]
bortezomib in combo w/ cyclophosphamide & rituximab http://bit.ly/8zuvRg
usclinicaltrial (US Clinical Trials) Tue, 15 Dec 2009 23:58:43 -0000
bortezomib in combo w/ cyclophosphamide & rituximab http://bit.ly/8zuvRg
bortezomib in combo w/ cyclophosphamide & rituximab http://bit.ly/8zuvRg
recruitingtrial (Recruiting Trials) Tue, 15 Dec 2009 23:10:49 -0000
bortezomib in combo w/ cyclophosphamide & rituximab http://bit.ly/8zuvRg
Blood: Results of a phase II study of bortezomib in patients with relapsed or refractory indolent lymph... www.amedeo.com/c.php?i=19965689
AmedeoSelection (Amedeo Selection) Tue, 15 Dec 2009 23:00:09 -0000
Blood: Results of a phase II study of bortezomib in patients with relapsed or refractory indolent lymph... www.amedeo.com/c.php?i=19965689
RT @myelomatrials RT @usclinicaltrial obatoclax & bortezomib in treating ppl w/ relapsed or refractory multiple myeloma http:/...
myelomatrials (Myeloma Trials) Tue, 15 Dec 2009 22:21:03 -0000
RT @myelomatrials RT @usclinicaltrial obatoclax & bortezomib in treating ppl w/ relapsed or refractory multiple myeloma http:/...
bortezomib & docetaxel in treating ppl w/ recurrent or metastatic head & neck cancer http://bit.ly/5T2NXp
localtrials (US Clinical Trials ) Tue, 15 Dec 2009 19:34:45 -0000
bortezomib & docetaxel in treating ppl w/ recurrent or metastatic head & neck cancer http://bit.ly/5T2NXp
bortezomib & docetaxel in treating ppl w/ recurrent or metastatic head & neck cancer http://bit.ly/5T2NXp
usclinicaltrial (US Clinical Trials) Tue, 15 Dec 2009 18:50:47 -0000
bortezomib & docetaxel in treating ppl w/ recurrent or metastatic head & neck cancer http://bit.ly/5T2NXp
MedlinePlus: Bortezomib (Systemic) - Provides information on usage, precautions, side effects and brand names when available. Data provided by government agencies and health-related organizations
Meta Description: [ Bortezomib(Systemic) ]
Velcade (PS-341) - Description, mechanism of action, side effects, and other information, from the Multiple Myeloma Research Foundation.
| ASH 2006 - Dr. Dispenzieri discusses Velcade Results | |
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