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Biperiden is an antiparkinsonian agent of the anticholinergic type. Chemically it is referred to as 3-Piperidino-1-phenyl-1-bicycloheptenyl-propanol(1). The original brand name - still existing - is Akineton® manufactured by BASF/Knoll Pharma. Generics are available worldwide.
Pharmacokinetics
The oral bioavailability is only 33 +/- 5% due to an excessive first-pass-metabolization. In young, healthy volunteers peak plasma concentrations following an oral single dose of 4mg in immediate release form are reached after 1.5 hours. The elimination-halflife has been determined as 18.4 hours, and may be prolonged in geriatric patients. After i.v. dosing of 4mg the elimination halflife is approximately 24 hours.
Pharmacology
Biperiden has an atropine-like blocking effect on all perpheral structures, which are parasympathetíc-innervated (e.g. cardiovascular and visceral organs). It also has a prominent central blocking effect on M1-Receptors. More on [ Biperiden ]
MedlinePlus: Antidyskinetics (Systemic) - Data provided by NLM, the National Institutes of Health (NIH), and other government agencies and health-related organizations. Provides information on usage, precautions, side effects and brand names when available.
Meta Description: [ Antidyskinetics (Systemic) ]
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