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Baclofen (brand names Kemstro® and Lioresal®) is a derivative of gamma-aminobutyric acid, and is an agonist specific to mammalian but not fruit fly (Drosophila) GABAB receptors**. It is used for the treatment of spastic movement, especially in instances of spinal cord injury and in multiple sclerosis. Its beneficial effects result from actions at spinal and supraspinal sites. Baclofen can also be used to treat hiccups.
Description of compound
Baclofen is a white to off-white, odorless or practically odorless crystalline powder, with a molecular weight of 213.66 g/mol. It is slightly soluble in water, very slightly soluble in methanol, and insoluble in chloroform.
Routes of administration
Baclofen can be administered either orally or intrathecally (directly into the spinal fluid). Intrathecal administration is often indicated in spasticity patients, as very little of the oral dose actually reaches the spinal fluid. More on [ Baclofen ]
ITB Therapy - Learn about the Intrathecal Baclofen Pump, an implantable therapy to treat severe spasticity caused by multiple sclerosis, cerebral palsy, stroke, and other conditions.
Meta Description: [ Information about Medtronic Intrathecal Baclofen (ITB TM) Therapy for Severe Spasticity ]
MedlinePlus: Baclofen Oral - Provides information about dosage, usage, warnings, and side effects.
Meta Description: [ Baclofen Oral ]
