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Baclofen (brand names Kemstro® and Lioresal®) is a derivative of gamma-aminobutyric acid, and is an agonist specific to mammalian but not fruit fly (Drosophila) GABAB receptors**. It is used for the treatment of spastic movement, especially in instances of spinal cord injury and in multiple sclerosis. Its beneficial effects result from actions at spinal and supraspinal sites. Baclofen can also be used to treat hiccups.

Description of compound


Baclofen is a white to off-white, odorless or practically odorless crystalline powder, with a molecular weight of 213.66 g/mol. It is slightly soluble in water, very slightly soluble in methanol, and insoluble in chloroform.

Routes of administration


Baclofen can be administered either orally or intrathecally (directly into the spinal fluid). Intrathecal administration is often indicated in spasticity patients, as very little of the oral dose actually reaches the spinal fluid.

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Leashes How Can Baclofen Help Multiple Sclerosis and Cerebral Palsy?: Drugs like Baclofen are generating to be imme... http://bit.ly/7hdLNa
uyosemite (Jasper Burgton) Wed, 16 Dec 2009 18:27:07 -0000
Leashes How Can Baclofen Help Multiple Sclerosis and Cerebral Palsy?: Drugs like Baclofen are generating to be imme... http://bit.ly/7hdLNa
Cerebral Palsy : Leashes How Can Baclofen Help Multiple Sclerosis and Cerebral Palsy? http://bit.ly/8lrDjH
uyosemite (Jasper Burgton) Wed, 16 Dec 2009 18:00:38 -0000
Cerebral Palsy : Leashes How Can Baclofen Help Multiple Sclerosis and Cerebral Palsy? http://bit.ly/8lrDjH
@mom2manykids I am officially having the Baclofen pump surgery again in January! :D
slayerchick303 (Mandi Mateer) Tue, 15 Dec 2009 21:51:30 -0000
@mom2manykids I am officially having the Baclofen pump surgery again in January! :D
I am officially having the Baclofen pump surgery again in January! :D
slayerchick303 (Mandi Mateer) Tue, 15 Dec 2009 21:50:58 -0000
I am officially having the Baclofen pump surgery again in January! :D
@jennifermf Well, melatonin alone just knocked me out, adding either inositol, ashwagandha or baclofen lets me sleep until the morning.
DiamonDie (Maija Haavisto) Tue, 15 Dec 2009 19:59:14 -0000
@jennifermf Well, melatonin alone just knocked me out, adding either inositol, ashwagandha or baclofen lets me sleep until the morning.
how to stop Baclofen Pump Therapy and get natural treatment? http://bit.ly/6bEnmV
atruthhurt (yan nuri) Mon, 14 Dec 2009 11:53:03 -0000
how to stop Baclofen Pump Therapy and get natural treatment? http://bit.ly/6bEnmV

 
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ITB Therapy - Learn about the Intrathecal Baclofen Pump, an implantable therapy to treat severe spasticity caused by multiple sclerosis, cerebral palsy, stroke, and other conditions.
Meta Description: [ Information about Medtronic Intrathecal Baclofen (ITB TM) Therapy for Severe Spasticity ]

MedlinePlus: Baclofen Oral - Provides information about dosage, usage, warnings, and side effects.
Meta Description: [ Baclofen Oral ]

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