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An antidepressant is a medication designed to treat or alleviate the symptoms of clinical depression. Some antidepressants, notably the tricyclics, are commonly used off-label in the treatment of neuropathic pain, whether or not the patient is depressed. Smaller doses are generally used for this purpose, and they often take effect more quickly. Many antidepressants also are used for the treatment of anxiety disorders, and tricyclic antidepressants are used in the treatment of chronic pain disorders such as chronic functional abdominal pain (CFAP), myofascial pain syndrome, and post-herpetic neuralgia.

The main classes of antidepressants have similar efficacy, but the newer types are generally regarded to have a more benign side-effect profile and less risk of lethality if taken in overdose.

History


Like many psychiatric drugs, antidepressants were discovered by accident. The first useful antidepressants belonged to a group called MAOIs (MonoAmine Oxidase Inhibitors) and were discovered in the early 1950s. The original member of this group was iproniazid, which was originally developed to treat tuberculosis. The next group were the tricyclic antidepressants. The first was imipramine. They were effective and safer than the MAOI but still quite dangerous in overdose. They are still used today but have been largely replaced by another group: SSRIs (Selective Serotonin Reuptake Inhibitors). The first SSRI was fluoxetine. Drugs from all three groups have been found to improve the mood of depressed patients. The SSRI antidepressants were early examples of rational drug design.

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Recession sees antidepressant use soar: The recession has seen the volume of antidepressants being prescribed .. http://bit.ly/8w9cid
TMSchicago (Larry Robbins) Tue, 15 Dec 2009 18:06:21 -0000
Recession sees antidepressant use soar: The recession has seen the volume of antidepressants being prescribed .. http://bit.ly/8w9cid
Antidepressants increase stroke risk http://ff.im/-cXaMR
PressTVNews (Press TV ) Tue, 15 Dec 2009 18:02:22 -0000
Antidepressants increase stroke risk http://ff.im/-cXaMR
Increased risk of death, stroke in postmenopausal women taking antidepressants, study finds http://j.mp/8Mrqfu
CandiceND (Candice Esposito) Tue, 15 Dec 2009 17:57:37 -0000
Increased risk of death, stroke in postmenopausal women taking antidepressants, study finds http://j.mp/8Mrqfu
Antidepressants: Prozac antidepressants 'risk for menopausal woman' | News ... http://bit.ly/6gsVbf
vitarleton (Vicataria Tarleton) Tue, 15 Dec 2009 17:33:27 -0000
Antidepressants: Prozac antidepressants 'risk for menopausal woman' | News ... http://bit.ly/6gsVbf
http://antidepressants.comxa.com/prozac-antidepressants-risk-for-menopausal-woman-news/
vitarleton (Vicataria Tarleton) Tue, 15 Dec 2009 17:33:26 -0000
http://antidepressants.comxa.com/prozac-antidepressants-risk-for-menopausal-woman-news/
Antidepressants: Antidepressants May Raise Women's Stroke Risk - WAFB Channel 9 ... http://bit.ly/7qPuiQ
vitarleton (Vicataria Tarleton) Tue, 15 Dec 2009 17:33:24 -0000
Antidepressants: Antidepressants May Raise Women's Stroke Risk - WAFB Channel 9 ... http://bit.ly/7qPuiQ

 
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Antidepressant Drug Database - Prescribing information for anti-depressant drugs arranged alphabetically by brand name.
Meta Description: [ Pharmaceutical News; reliable drug information for patients and pharmaceutical marketing professionals; Pharmaceutical Sales - free Advice on how to land job ]

Antidepressants Facts - News, essays, and links supporting the view that antidepressant medications are dangerous and unnecessary, presented by an individual self-described as a anti-depressant survivor. Includes information about specific drugs.
Meta Description: [ Antidepressants Facts, Side-Effects & Safety. SSRI & SSNRI anti-depressants research, articles, studies, personal experiences, views of doctors.. ]

Drug Comparisons: Miscellaneous Antidepressants - Brief discussion from DrugDigest of medications that aren't included in any of the main classes of antidepressant drugs.

Drug Treatment of Depression - Risks and Benefits - Provides expert, consumer friendly information on mental health and aging.
Meta Description: [ Learn about depression medications and antidepressants: how and why they're prescribed, side effects, alternatives, and controversies. Includes non-commercial resources and expert information. ]

Drugs for Depression: Thomas J. Moore's Site - Information about the side effects of depression drugs. Site questions the benefit of these drugs.
Meta Description: [ Drugs for depression are overrated, and their dangers greater than many people think. The facts are on this page ]

MAOI Diet - A review of the dietary restrictions that should be observed when a patient is receiving monoamine oxidase inhibitor (MAOI) therapy.

Medication Profiles: Tricyclic Antidepressants - Information on benefits, disadvantages, side effects, and dosage recommendations for a variety of TCAs.
Meta Description: [ Panic Attacks Anxieties Anxiety Attacks OCD Social Anxiety Disorder , Anxiety disorder, Anxiety attacks, Anxiety symptoms, Social anxieties, Generalized anxiety disorder, Social anxiety disorder, Anxiety medication, Anxiety depression, Anxiety attack symptom, Anxiety treatment Anxiety drugs

New Antidepressant Label Addresses Suicidality - An article published by the Medical College of Wisconsin about the FDA's black box warning added to the labels of antidepressants.
Meta Description: [ A warning about the increased risk of suicidal thoughts and behavior will appear in bold type on package inserts, but the FDA stresses that the new label should not be viewed as prohibiting the use of antidepressants in treating young patients. ]

New Vistas in Antidepressant Development - Article written for medical professionals explores current directions in research and development of medications to treat depression, focusing on novel classes of drugs that show promise in preclinical or clinical studies. [Requires free registration.]

NPR : FDA Study Links Antidepressants, Teen Suicide - US Food and Drug Administration study seems to confirm suspicions that antidepressant drugs may increase the risk of suicidal behavior in children and teens. Study re-examined nine different antidepressants, finding that young people were more likely to harm themselves on these drugs than on placebos. [3:39 streaming audio broadcast]
Meta Description: [ A Food and Drug Administration study seems to confirm suspicions that antidepressant drugs may increase the risk of suicidal behavior in children and teens. The FDA re-examined nine different antidepressants. It found that young people given the drugs were more likely to harm themselves than thos... ]

Prozac Spotlight - Contains commentaries on personal experiences with antidepressants. Advertisement parodies.

Psychology Information Online: Medication for Depression - Facts and figures on a variety of categories of depression treatment medications.
Meta Description: [ Information about medication for depression ]

Side Effect Registry - Database of antidepressant side effects reports submitted by website users (psychiatrists, pharmacists and other prescribers). Maintained by Priory Lodge Education Limited.

The Pharmacologic Treatment of Depression - Article for family practice doctors reviews the various antidepressant medications available in the United States. [Registration required.]

What Foods You Should Avoid on MAOIs - A review of the dietary restrictions for patients receiving monoamine oxidase inhibitor therapy.

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