}
Chemical name	}
Other names	1,7-heptanedicarboxylic acid
Chemical formula	C9H16O4
Molecular mass	} g/mol
CAS number	*
Melting point	} °C
Boiling point	} °C at 20 mmHg
SMILES	}
Chemical infobox

Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is a natural substance that is produced by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. It is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. Azelaic acid may be useful as a hair growth stimulant.

Properties

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Azelaic acid is:

• Antibacterial: it reduces the growth of bacteria in the follicle (Proprionibacterium acnes and Staphylococcus epidermidis);
• Keratolytic & comedolytic: it returns to normal, the disordered growth of the skin cells, lining the follicle; and
• Scavenger of free radicals: it reduces inflammation.
• Reduces pigmentation: it is particularly useful for darker-skinned patients, who have melasma, or whose acne spots leave persistent brown marks; (Per the product insert: "There have been reports of hypopigmentation after use of azelaic acid. Since azelaic acid has not been well studied in patients with dark complexions, these patients should be monitored for early signs of hypopigmentation.")
• Non-toxic, and is well tolerated by most patients.

More on [ Azelaic acid ]

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CFDA: FDA Latest Drug GCP Warning Letters

WL Issued to Coast Institutional Review Board
FDA Tue, 14 Apr 2009 00:00:00 -0400
FDA Warning Letter Issued to Coast Institutional Review Board on 14 Apr 2009 by Center for Drug Evaluation and Research
WL Issued to Branitz, Bruce, MD
FDA Thu, 09 Apr 2009 00:00:00 -0400
FDA Warning Letter Issued to Branitz, Bruce, MD on 09 Apr 2009 by Center for Drug Evaluation and Research
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FDA Warning Letter Issued to Youabian, Inc on 17 Mar 2009 by Los Angeles District Office
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FDA Warning Letter Issued to Provena St. Joseph's Medical Center IRB on 12 Mar 2009 by Center for Biologics Evaluation and Research
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FDA Warning Letter Issued to Paulson, Daniel M., MD on 11 Mar 2009 by Center for Drug Evaluation and Research

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