Azathioprine is a chemotherapy drug, now rarely used for chemotherapy but more for immunosuppression in organ transplantation, autoimmune disease such as rheumatoid arthritis or inflammatory bowel disease such as Crohn's disease. It is a pro-drug, converted in the body to the active metabolites 6-mercaptopurine and 6-thioinosinic acid.

Azathioprine is produced by a number of generic manufacturers and as branded names (Azasan® by Salix in US and Imuran® by GlaxoSmithKline in UK).

History

---

Azathioprine was first introduced into clinical practice by Sir Roy Calne, the British pioneer in transplantation. Following the work done by Sir Peter Medawar in discovering the immunological basis of rejection of transplanted tissues and organs, Calne introduced 6-mercaptopurine as an experimental immunosuppressant for kidney transplants. When azathioprine was discovered, he then introduced it as a less toxic replacement for 6-mercaptopurine. For many years, dual therapy with azathioprine and steroids was the standard anti-rejection regime, until cyclosporine was introduced into clinical practice (also by Calne) in 1978.

More on [ Azathioprine ]

Azathioprine - Twitter Search

Can-mothers-breast-feed-while-taking-azathioprine? #medicine #pregnancy #obstetrics #fb http://bit.ly/1d2V9X
ravimohanv (Vel Ravimohan) Sat, 07 Nov 2009 12:14:44 -0000
Can-mothers-breast-feed-while-taking-azathioprine? #medicine #pregnancy #obstetrics #fb http://bit.ly/1d2V9X
davidcbalfour:: Re: side-effects of azathropine: I've been on azathioprine for about 5 years now - currently on.. http://bit.ly/420Xho
ColitisUK (Colitis UK) Mon, 02 Nov 2009 11:14:37 -0000
davidcbalfour:: Re: side-effects of azathropine: I've been on azathioprine for about 5 years now - currently on.. http://bit.ly/420Xho
Smell the Fear | ChangingAging.org: It is caused not by the very presence of a person is diagnosed azathioprine.. http://tinyurl.com/y854zn9
NCNAcneFacials (James Nsien 2) Mon, 02 Nov 2009 03:47:45 -0000
Smell the Fear | ChangingAging.org: It is caused not by the very presence of a person is diagnosed azathioprine.. http://tinyurl.com/y854zn9
Crohn S Disease: The use of infliximab (IFX) plus azathioprine (AZA) and infliximab monotherapy increase the l.. http://bit.ly/3sHpTR
eg45gf (Jesse Stephens) Sun, 01 Nov 2009 11:57:23 -0000
Crohn S Disease: The use of infliximab (IFX) plus azathioprine (AZA) and infliximab monotherapy increase the l.. http://bit.ly/3sHpTR
@esmereldagreen Never tried that one, once off mesalazine I was only offered azathioprine (Chose LDN which wasn't offered ; )
bobthomson70 (bobthomson70) Sat, 31 Oct 2009 20:17:51 -0000
@esmereldagreen Never tried that one, once off mesalazine I was only offered azathioprine (Chose LDN which wasn't offered ; )
*BugJemm*:: Re: could there be any truth to this: I've been on azathioprine for my colitis for seven years. For.. http://bit.ly/2y6aYr
ColitisUK (Colitis UK) Fri, 30 Oct 2009 11:43:54 -0000
*BugJemm*:: Re: could there be any truth to this: I've been on azathioprine for my colitis for seven years. For.. http://bit.ly/2y6aYr

Subscribe to Azathioprine RSS feed