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Atovaquone is a chemical compound that belongs to the class of naphthalenes. Atovaquone is a hydroxy-1,4-naphtoquinone, an analog of ubiquinone, with antipneumocystic activity.

Atovaquone is a medication used to treat or prevent:

  1. Pneumocystis carinii pneumonia (PCP), although it is not approved for treatment of severe PCP.
  2. Toxoplasmosis. The medication has antiparasitic and therapeutic effects.
  3. Malaria. It is one of the two components (along with proguanil) in the drug Malarone. Malarone has fewer side effects than mefloquine, but can be more expensive because it's taken daily. (Source)

Trimotheoprim-sulfamethoxazole (TMP-SMX, Bactrim) is generally considered first line therapy for PCP or toxoplasmosis. However, atovaquone may be used in patients who cannot tolerate, or are allergic to, TMP-SMX. In addition, atovaquone has the advantage of not causing myelosuppression, which is an important issue in patients who have undergone bone marrow transplantation.

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@SethAYoung yes, atovaquone/proguanil shortest but also most expensive
DoctorChristian (Dr Christian Jessen) Sat, 21 Jan 2012 12:27:02 -0000
@SethAYoung yes, atovaquone/proguanil shortest but also most expensive
@mattjohnsonuk atovaquone proguanil is the proper name for malarone? One tablet daily and start two days before u get there and a wk after
eimearmcb (Eimear McBrearty) Tue, 17 Jan 2012 16:55:23 -0000
@mattjohnsonuk atovaquone proguanil is the proper name for malarone? One tablet daily and start two days before u get there and a wk after

 
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DrugDigest: Atovaquone ( Mepron ) - Information on dosage, usage, side effects, interactions, and drug comparisons including generics when available.

DrugDigest: Atovaquone and Proguanil ( Malarone ) - Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available.

Malarone - Information for health care professionals and patients on malaria, its treatment, and prophylaxis using Malarone (atovaquone proguanil HCI) tablets from GlaxoSmithKline.

MedlinePlus: Atovaquone - Features information about dosage, usage, warnings, and side effects.
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Mepron - a.k.a. Atovaquone.

Mepron - Prescribing information in pdf format.

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