Astemizole (marketed under the brand name Hismanal) is a second generation antihistamine drug which has a long duration of action. It has been withdrawn from the market in most countries because of rare but potentially fatal interactions with CYP34A enzyme inhibitors.

Pharmacology

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Astemizole is an histamine H1-receptor antagonist. It is structurally similar to terfenadine and haloperidol (a butyrophenone antipsychotic). It has anticholinergic and antipruritic effects.

Astemizole competitively binds to histamine H1-receptor sites in the gastrointestinal tract, uterus, blood vessels, and bronchial muscle. This suppresses the formation of edema and pruritus (caused by histamine).

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Drug-drug interactions? Where are you? Terfenadine? Astemizole? What's your MOA? Sus! kung gn-emote ko ni kung gnpangita ko gro! LOL ah!
bebepiginpink (Bebe Bantugay) Wed, 09 Nov 2011 13:12:45 -0000
Drug-drug interactions? Where are you? Terfenadine? Astemizole? What's your MOA? Sus! kung gn-emote ko ni kung gnpangita ko gro! LOL ah!

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