Asparaginase () is an enzyme which is used to treat acute lymphoblastic leukemia (ALL). It is marketed under the brand name Elspar®. It can be given intramuscularly or intravenously.

Mechanism of action

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The rationale behind asparaginase is that it takes advantage of the fact that ALL cells are unable to synthesize the non-essential amino acid asparagine whereas normal cells are able to make their own asparagine. These leukemic cells depend on circulating asparagine. Asparaginase however catalyzes the conversion of L-asparagine to aspartic acid and ammonia. This deprives the leukemic cell of circulating asparagine.

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#Biochemistry extraction of asparaginase from some plants http://bit.ly/1wxnTD
SciSolutions (Scientist Solutions) Thu, 08 Oct 2009 21:43:10 -0000
#Biochemistry extraction of asparaginase from some plants http://bit.ly/1wxnTD

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