Asparaginase () is an enzyme which is used to treat acute lymphoblastic leukemia (ALL). It is marketed under the brand name Elspar®. It can be given intramuscularly or intravenously.

Mechanism of action

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The rationale behind asparaginase is that it takes advantage of the fact that ALL cells are unable to synthesize the non-essential amino acid asparagine whereas normal cells are able to make their own asparagine. These leukemic cells depend on circulating asparagine. Asparaginase however catalyzes the conversion of L-asparagine to aspartic acid and ammonia. This deprives the leukemic cell of circulating asparagine.

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safety & tolerability clofarabine, etoposide, cyclophosphamide, peg-asparaginase, & vincristine in pediatric acute http://bit.ly/69dKZ7
paidtrials (US Clinical Trials) Sun, 13 Dec 2009 05:42:48 -0000
safety & tolerability clofarabine, etoposide, cyclophosphamide, peg-asparaginase, & vincristine in pediatric acute http://bit.ly/69dKZ7
intensified post remission thrpy containing peg-asparaginase http://bit.ly/5Ds4g6
usclinicaltrial (US Clinical Trials) Sun, 13 Dec 2009 02:34:51 -0000
intensified post remission thrpy containing peg-asparaginase http://bit.ly/5Ds4g6
intensified post remission thrpy containing peg-asparaginase http://bit.ly/5Ds4g6
recruitingtrial (Recruiting Trials) Sun, 13 Dec 2009 01:30:52 -0000
intensified post remission thrpy containing peg-asparaginase http://bit.ly/5Ds4g6
erwinia asparaginase after allergy 2 peg-asparaginase in treating young ppl w/ acute lymphoblastic leukemia http://bit.ly/86wBpU
paidtrials (US Clinical Trials) Fri, 11 Dec 2009 14:10:54 -0000
erwinia asparaginase after allergy 2 peg-asparaginase in treating young ppl w/ acute lymphoblastic leukemia http://bit.ly/86wBpU
safety & tolerability clofarabine, etoposide, cyclophosphamide, peg-asparaginase, & vincristine in pediatric acute http://bit.ly/6Pmvjq
cancertrials_ (Cancer Trials) Wed, 09 Dec 2009 05:30:53 -0000
safety & tolerability clofarabine, etoposide, cyclophosphamide, peg-asparaginase, & vincristine in pediatric acute http://bit.ly/6Pmvjq
safety & tolerability clofarabine, etoposide, cyclophosphamide, peg-asparaginase, & vincristine in pediatric acute http://bit.ly/5k8F6X
bostontrials (Boston Trials) Wed, 09 Dec 2009 04:38:54 -0000
safety & tolerability clofarabine, etoposide, cyclophosphamide, peg-asparaginase, & vincristine in pediatric acute http://bit.ly/5k8F6X

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