Antithrombin is a small molecule that inactivates several enzymes of the coagulation system. It is a glycoprotein produced by the liver.

Function

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Antithrombin is a serpin (serine protease inhibitor) that inactivates a number of enzymes from the coagulation system, namely the activated forms of Factor X, Factor IX, Factor II (thrombin), Factor VII, Factor XI, and Factor XII. Its affinity for these molecules (i.e. its effectivity) is enhanced by heparin.

Role in disease

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Antithrombin deficiency is a rare hereditary disorder that generally comes to light when a patient suffers recurrent venous thrombosis and pulmonary embolism. This was first described by Egeberg in 1965. The patients are treated with anticoagulants or, more rarely, with antithrombin concentrate.

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#Hematología REGULATORY REGIONS OF SERPINC1 GENE: IDENTIFICATION OF THE FIRST MUTATION ASSOCIATED WITH ANTITHROMBIN... http://t.co/DEkoce2q
MedibooksEs (Medibooks) Fri, 03 Feb 2012 08:27:04 -0000
#Hematología REGULATORY REGIONS OF SERPINC1 GENE: IDENTIFICATION OF THE FIRST MUTATION ASSOCIATED WITH ANTITHROMBIN... http://t.co/DEkoce2q
(TAT) =（thrombin-antithrombin complex）=トロンビン・アンチトロンビンⅢ複合体
daiyasan23 (だいやん) Thu, 02 Feb 2012 02:02:31 -0000
(TAT) =（thrombin-antithrombin complex）=トロンビン・アンチトロンビンⅢ複合体

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