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Basic Chemical, Pharmacological and Marketing Data
Anakinra is an IL-1 receptor antagonist. The anakinra molecule is a recombinant, non glycosolated version of human IL-1RA (RA for receptor antagonist). It consists of 153 amino acids and has a molecular weight of 17,257.6 g/mol (approx. 17.3 kilodaltons) and differs from native human IL-1RA in that it has the addition of a single methionine residue on its amino terminus.
The substance is a biologic response modifier. It is prepared from cultures of genetically modified Escherichia coli using recombinant DNA technology.
Anakinra blocks the biologic activity of naturally occuring IL-1, including inflammation and cartilage degradation associated with rheumatoid arthritis, by competetively inhibiting the binding of IL-1 to the Interleukin-1 type receptor, which is expressed in many tissues and organs. IL-1 is produced in response to inflammatory stimuli and mediates various physiologic responses, including inflammatory and immunologic reactions. IL-1 additionally stimulates bone resorption and induces tissue damage like cartilage degradation as a result of loss of proteoglycans. In patients with rheumatoid arthritis the natural IL-1 receptor antagonist is not found in effective concentrations in synovium and synovial fluid to counteract the elevated IL-1 concentrations in these patients.
More on [ Anakinra ]
Rheum: Long-term efficacy of the interleukin-1 receptor antagonist anakinra in ten patients with neonatal-onset multisy http://url4.eu/13ATx
MDLinx (Sandeep Pulim MD) Mon, 04 Jan 2010 09:23:21 -0000
Rheum: Long-term efficacy of the interleukin-1 receptor antagonist anakinra in ten patients with neonatal-onset multisy http://url4.eu/13ATx
my daughter's name will be 'anakinra'. It's a drug of choice for juvenille reumathoid arthritis. How beautiful..ANAKINRA..
amandanandi (amanda wardani) Sat, 02 Jan 2010 15:25:20 -0000
my daughter's name will be 'anakinra'. It's a drug of choice for juvenille reumathoid arthritis. How beautiful..ANAKINRA..
biologic DMARD: anakinra...can't help but think about lightsabers
aditsr (Adhitya SR) Sat, 02 Jan 2010 08:20:12 -0000
biologic DMARD: anakinra...can't help but think about lightsabers
Anakinra ( Kineret ) - Patient and physician information for this medication, which is used to relieve pain and swelling caused by rheumatoid arthritis.
MedlinePlus: Anakinra - Features information about dosage, usage, warnings, and side effects.
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