Amitriptyline hydrochloride (sold as Elavil®, Tryptanol®, Endep®, Elatrol®, Tryptizol®) is a tricyclic antidepressant drug. It is a white, odorless, crystalline compound which is freely soluble in water and usually dispensed in tablet form. The empirical formula of its hydrochloride salt is C₂₀H₂₃N·HCl.

Mechanism of Action

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Amitriptyline affects serotonin and noradrenaline reuptake almost equally.

Uses

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Approved

Amitriptyline is approved for the treatment of endogenous depression and involutional melancholia (depression of late life, which is no longer seen as a disease in its own right),Weissman MM. "The myth of involutional melancholia." Journal of the American Medical Association. 1979 Aug 24-31;242(8):742-4. PMID 459064 and reactive depression and for depression secondary to alcoholism and schizophrenia. Adult typical dosages are 75 to 200mg daily, with half this initially for elderly or adolescents.

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ManuraNanayakka (Manura Nanayakkara) Sat, 31 Dec 2011 04:31:06 -0000
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ladyhee87 (Arzy Dwi ) Sat, 31 Dec 2011 02:47:19 -0000
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