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Tissue plasminogen activator (abbreviated PLAT or tPA) is a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism.
Gene
Alternative splicing of the PLAT gene, PLAT, produces three transcripts.
Applications
Recombinant PLAT is used in diseases which feature blood clots, such as myocardial infarction and stroke. To be effective, PLAT must be administered within the first six or so hours of the attack. The guideline in Ontario, Canada hospitals for ischemic strokes is that tPA must be given within 3 hours of the onset of symptoms. Because of this, only about 3% of patients qualify for this treatment. Since PLAT dissolves blood clots, there is risk of hemorrhage with its use. More on [ Tissue plasminogen activator ]
ClinicalNews:#Cerebral_Infarction #Intracranial_Hemorrhages #Stroke #Alteplase DRAGON Score Foretells tPA Outcomes.. http://t.co/NAGOUiL0
SciBite (Bio-News Nuggets) Fri, 10 Feb 2012 05:18:22 -0000
ClinicalNews:#Cerebral_Infarction #Intracranial_Hemorrhages #Stroke #Alteplase DRAGON Score Foretells tPA Outcomes.. http://t.co/NAGOUiL0
Intravenous alteplase in ischemic stroke patients not fully adhering to the current drug license in Central and... http://t.co/b5YEVVt6
Life_Sciences_ (Life Sciences) Thu, 09 Feb 2012 20:29:21 -0000
Intravenous alteplase in ischemic stroke patients not fully adhering to the current drug license in Central and... http://t.co/b5YEVVt6
Cl
Alteplase, Recombinant - Healthtouch - Brief summary for patients.
Cathflo Activase (Alteplase) - Genentech - Official pharmaceutical site intended for US health professionals for this medication used for restoration of function to central venous access devices.
Meta Description: [ Cathflo.com is your source for information about blood clots (thrombotic occlusions) in central venous catheters (CVCs) and about Cathflo Activase (a thrombolytic agent). Cathflo Activase (Alteplase) from Genentech, Inc. Right for the patient, right for the clinic. ]
MedlinePlus: Thrombolytic Agents (Systemic) - Features information about dosage, usage, warnings, and side effects.
Meta Description: [ Thrombolytic Agents(Systemic) ]
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