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Alosetron is a 5-HT3 antagonist used for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women only. It was withdrawn from the market in 2000 owing to the occurrence of serious life-threatening gastrointestinal adverse effects, but was reintroduced in 2002 with availability and use restricted. It is currently marketed by GlaxoSmithKline under the trade name Lotronex.
Mode of action
Alosetron, while being a 5-HT3 antagonist like ondansetron, is not an antiemetic. Alosetron has an antagonist action on the 5-HT3 receptors of the enteric nervous system of the gastrointestinal tract.
Serious adverse effects
Alosetron was withdrawn in 2000 following the association of alosetron with serious life-threatening gastrointestinal adverse effects. More on [ Alosetron ]
Evaluation of treatment continuation with alosetron by IBS-D severity criteria: Current Medical Research and Opi... http://t.co/lNWXTD2M
CMRO_Journal (CMRO Medical Journal) Wed, 08 Feb 2012 04:56:10 -0000
Evaluation of treatment continuation with alosetron by IBS-D severity criteria: Current Medical Research and Opi... http://t.co/lNWXTD2M
Via @CMRO_Journal Evaluation of treatment continuation with alosetron by IBS-D severity criteria: Current Medica... http://t.co/ofCh9QUI
Editage (English Editing) Wed, 08 Feb 2012 04:26:54 -0000
Via @CMRO_Journal Evaluation of treatment continuation with alosetron by IBS-D severity criteria: Current Medica... http://t.co/ofCh9QUI
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Lotronex (Alosetron HCI) - GSK - Official pharmaceutical website with information for patients and care givers.
Lotronex Information - FDA - Includes information for patients and care givers with links to current (re-released)product information and information about the previous withdrawal from the market in 2000.
Meta Description: [ Drug Information about Lotronex ]
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