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Aciclovir (INN) (IPA: ) or acyclovir (USAN, former BAN) is a guanine analogue antiviral drug used most commonly for the treatment of herpes simplex virus infection. It is one of the most commonly-used antiviral drugs, and is most commonly marketed under the trade name Zovirax (GSK).
Aciclovir was seen as the start of a new era in antiviral therapy, as it is extremely selective and low in cytotoxicity. Pharmacologist Gertrude B. Elion was awarded the 1988 Nobel Prize in Medicine partly for the development of aciclovir.
Pharmacology
Mechanism of action
Aciclovir differs from previous nucleoside analogues in that it contains only a partial nucleoside structure – the sugar ring is replaced by an open-chain structure. It is selectively converted into a monophosphate form by viral thymidine kinase, which is far more effective (3000 times) in phosphorylation than cellular thymidine kinase. Subsequently, the monophosphate form is further phosphorylated into the active triphosphate form, aciclo-GTP, by cellular kinases. Aciclo-GTP is a very potent inhibitor of viral DNA polymerase; it has approximately 100 times higher affinity to viral than cellular polymerase. Its monophosphate form also incorporates into the viral DNA, resulting in chain termination. It has also been shown that the viral enzymes cannot remove aciclo-GMP from the chain, which results in inhibition of further activity of DNA polymerase. Aciclo-GTP is fairly rapidly metabolised within the cell, possibly by cellular phosphatases. More on [ Aciclovir ]
so this sickness is going away. it only took amoxicillin, acyclovir, tylenol with codeine, robitussin, and whiskey and honey to do it too!
kiksngiggles (Keeley Moseley) Sun, 08 Nov 2009 03:57:39 -0000
so this sickness is going away. it only took amoxicillin, acyclovir, tylenol with codeine, robitussin, and whiskey and honey to do it too!
finally done with the old acyclovir
JonathanVHall (Jonathan Victor Hall) Sat, 07 Nov 2009 21:22:28 -0000
finally done with the old acyclovir
Keren tu.. Pke acyclovir aja..RT @ya_sTaR: @sandersonambela Worst! Ndk ada mmg anti pirus na, gara2 bnyk dudu terinstal..saling meniadakan..
sandersonambela (Sander Sonambela) Sat, 07 Nov 2009 10:36:41 -0000
Keren tu.. Pke acyclovir aja..RT @ya_sTaR: @sandersonambela Worst! Ndk ada mmg anti pirus na, gara2 bnyk dudu terinstal..saling meniadakan..
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@beepohipo Oke gw jg adanya acyclovir deh kl ga salah. Boleh kok mandi mel, pake dettol ya. Yudi skg di bdg? Lo di clg gt?
fitriazizah (Fitri Azizah) Fri, 06 Nov 2009 00:39:00 -0000
@beepohipo Oke gw jg adanya acyclovir deh kl ga salah. Boleh kok mandi mel, pake dettol ya. Yudi skg di bdg? Lo di clg gt?
Acyclovir - Fact sheet for HIV and AIDS patients about this antiviral used to treat herpes genitalis, herpes simplex, and herpes zoster.
Acyclovir (Zovirax) - Patient information page about the use of this medication for HIV-related conditions.
DrugDigest: Acyclovir - Information on dosage, usage, side effects, interactions, and drug comparisons including generics when available.
DrugDigest: Zovirax - Information on dosage, usage, side effects, interactions, and drug comparisons including generics when available.
MedlinePlus Drug Information: Acyclovir - Advice for patients on this medication (brand name Zovirax) used to treat herpes infections.
Meta Description: [ Acyclovir ]
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Zovirax - Product information sheets from GlaxoSmithKline, providing prescribing information for acyclovir for administration orally, by injection, or as an ointment.
Meta Description: [ About GSK summarizes the mission of GSK and provides users with an overview of the organization and biographies of our Board of Directors and Corporate Executive Team. ]
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