Abacavir (ABC) is the most powerful nucleoside analog reverse transcriptase inhibitor (NARTI) used to treat HIV and AIDS. It is available under the trade name Ziagen™ (GlaxoSmithKline} and the combination drugs Trizivir™(abacavir, zidovodine and lamivudine) and Kivexa®/Epzicom™(abacavir and lamivudine) . It has been well tolerated; its main side effect being hypersensitivity reactions, which can be dangerous or even (in some rare cases) fatal. Fortunately, genetic testing can indicate beforehand whether an individual will be hypersensitive; over 90% of patients can safely take abacavir.
Viral strains that are resistant to zidovudine (AZT) or lamivudine (3TC) are generally sensitive to abacavir, whereas strains that are resistant to AZT and 3TC are not as sensitive to abacavir.
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History
Abacavir was approved by the
Food and Drug Administration (FDA) on
December 18,
1998 and is thus the fifteenth approved antiretroviral drug in the United States. Its patent will expire in the United States on
2009-12-26.
More on
[ Abacavir ]
CFDA: FDA Latest Computer Systems Warning LettersWL Issued to Amrex Zetron IncFDA Tue, 14 Apr 2009 00:00:00 -0400
FDA Warning Letter Issued to Amrex Zetron Inc on 14 Apr 2009 by Los Angeles District Office
WL Issued to Coast Institutional Review BoardFDA Tue, 14 Apr 2009 00:00:00 -0400
FDA Warning Letter Issued to Coast Institutional Review Board on 14 Apr 2009 by Center for Drug Evaluation and Research
WL Issued to Branitz, Bruce, MDFDA Thu, 09 Apr 2009 00:00:00 -0400
FDA Warning Letter Issued to Branitz, Bruce, MD on 09 Apr 2009 by Center for Drug Evaluation and Research
WL Issued to Cote, Charles J., MDFDA Mon, 02 Mar 2009 00:00:00 -0400
FDA Warning Letter Issued to Cote, Charles J., MD on 02 Mar 2009 by Center for Drug Evaluation and Research
WL Issued to Genzyme CorporationFDA Fri, 27 Feb 2009 00:00:00 -0400
FDA Warning Letter Issued to Genzyme Corporation on 27 Feb 2009 by New England District Office
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FDA Warning Letter Issued to Hammill Manufacturing Company on 06 Jan 2009 by Cincinnati District Office
CFDA: FDA Latest Drug GCP Warning LettersWL Issued to Coast Institutional Review BoardFDA Tue, 14 Apr 2009 00:00:00 -0400
FDA Warning Letter Issued to Coast Institutional Review Board on 14 Apr 2009 by Center for Drug Evaluation and Research
WL Issued to Branitz, Bruce, MDFDA Thu, 09 Apr 2009 00:00:00 -0400
FDA Warning Letter Issued to Branitz, Bruce, MD on 09 Apr 2009 by Center for Drug Evaluation and Research
WL Issued to Bukowski, Ronald M, MDFDA Mon, 30 Mar 2009 00:00:00 -0400
FDA Warning Letter Issued to Bukowski, Ronald M, MD on 30 Mar 2009 by Center for Drug Evaluation and Research
WL Issued to Youabian, IncFDA Tue, 17 Mar 2009 00:00:00 -0400
FDA Warning Letter Issued to Youabian, Inc on 17 Mar 2009 by Los Angeles District Office
WL Issued to Provena St. Joseph's Medical Center IRBFDA Thu, 12 Mar 2009 00:00:00 -0400
FDA Warning Letter Issued to Provena St. Joseph's Medical Center IRB on 12 Mar 2009 by Center for Biologics Evaluation and Research
WL Issued to Paulson, Daniel M., MDFDA Wed, 11 Mar 2009 00:00:00 -0400
FDA Warning Letter Issued to Paulson, Daniel M., MD on 11 Mar 2009 by Center for Drug Evaluation and Research
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Abacavir - Antiretroviral, reverse transcriptase inhibitor.
Abacavir, Zidovudine, and Lamivudine - AidsMeds.com - Consumer information on Trizivir with links to forums, general AIDS topics, and other resources for AIDS patients.
Meta Description: [ Complete info about Trizivir (abacavir + AZT + 3TC), a nucleoside analogue & treatment for HIV & AIDS. ]
DrugDigest: Abacavir ( Ziagen ) - Information on dosage, usage, side effects, interactions, and drug comparisons including generics when available.
MedlinePlus: Abacavir - Features information about dosage, usage, warnings, and side effects.
Meta Description: [ Abacavir ]
MedlinePlus: Abacavir and Lamivudine (Systemic) - Features information about dosage, usage, warnings, and side effects.
Meta Description: [ Abacavir(Systemic) ]
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Ziagen - Product information for US residents in PDF format. [Acrobat Reader required]
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