pubmed: 0302-2838Hurdles in Modern Trial Management: As Overbureaucracy and Commercialization of Clinical Trials Suffocate Independent Academic Research, It's Time for a Change. Osanto S, van Poppel H, Burggraaf J, Hall RR
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Hurdles in Modern Trial Management: As Overbureaucracy and Commercialization of Clinical Trials Suffocate Independent Academic Research, It's Time for a Change.
Eur Urol. 2009 Jun 23;
Authors: Osanto S, van Poppel H, Burggraaf J, Hall RR
PMID: 19560861 [PubMed - as supplied by publisher]
Medical Therapy to Facilitate the Passage of Stones: What Is the Evidence? Seitz C, Liatsikos E, Porpiglia F, Tiselius HG, Zwergel U
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Medical Therapy to Facilitate the Passage of Stones: What Is the Evidence?
Eur Urol. 2009 Jun 21;
Authors: Seitz C, Liatsikos E, Porpiglia F, Tiselius HG, Zwergel U
CONTEXT: Medical expulsive therapy (MET) for urolithiasis has gained increasing attention in the last years. It has been suggested that the administration of alpha-adrenoreceptor antagonists (alpha-blockers) or calcium channel blockers augments stone expulsion rates and reduces colic events. OBJECTIVE: To evaluate the efficacy and safety of MET with alpha-blockers and calcium channel blockers for upper urinary tract stones with and without prior extracorporeal shock wave lithotripsy (ESWL). EVIDENCE ACQUISITION: A systematic review of the literature was performed in Medline, Embase, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews searched through 31 December 2008 without time limit. Efficacy and safety end points were evaluated in 47 randomised, controlled trials assessing the role of MET. Meta-analysis was conducted using Review Manager (RevMan) v.5.0 (The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark). EVIDENCE SYNTHESIS: Pooling of alpha-blocker and calcium channel blocker studies demonstrated a higher and faster expulsion rate compared to a control group (risk ratio [RR]: 1.45 vs 1.49; 95% confidence interval [CI]: 1.34-1.57 vs 1.33-1.66). Similar results have been obtained after ESWL (RR: 1.29 vs 1.57; 95% CI: 1.16-1.43 vs 1.21-2.04). Additionally, lower analgesic requirements, fewer colic episodes, and fewer hospitalisations were observed within treatment groups. CONCLUSIONS: Pooled analyses suggest that MET with alpha-blockers or calcium channel blockers augments stone expulsion rates, reduces the time to stone expulsion, and lowers analgesia requirements for ureteral stones with and without ESWL for stones </=10mm. There is some evidence that a combination of alpha-blockers and corticosteroids might be more effective than treatment with alpha-blockers alone. Renal stones after ESWL also seem to profit from MET. The vast majority of randomised studies incorporated into the present systematic review are small, single-centre studies, limiting the strength of our conclusions. Therefore, multicentre, randomised, placebo-controlled trials are needed.
PMID: 19560860 [PubMed - as supplied by publisher]
The Motion: Robotic Partial Nephrectomy is Better than Open Partial Nephrectomy. Rogers CG, Patard JJ
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The Motion: Robotic Partial Nephrectomy is Better than Open Partial Nephrectomy.
Eur Urol. 2009 Jun 24;
Authors: Rogers CG, Patard JJ
PMID: 19560859 [PubMed - as supplied by publisher]
Refractory Hematuria in an Oliguric Patient After Pancreas Transplantation with Exocrine Pancreas Bladder Drainage. Kiss B, Birkhäuser FD, Fleischmann A, Candinas D, Studer UE, Kessler TM
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Refractory Hematuria in an Oliguric Patient After Pancreas Transplantation with Exocrine Pancreas Bladder Drainage.
Eur Urol. 2009 Jun 24;
Authors: Kiss B, Birkhäuser FD, Fleischmann A, Candinas D, Studer UE, Kessler TM
A 52-yr-old man presented with hematuria and clot retention. He had undergone simultaneous pancreas-kidney transplantation with exocrine pancreas bladder drainage 16 yr ago. The patient suffered from progressive transplant kidney failure with gradually decreasing urine output and needed hemodialysis every other day. Gross hematuria persisted after removal of all blood clots. Cystoscopy showed multiple small, flat ulcers of the bladder mucosa. Some bled discretely and were coagulated cautiously. However, hematuria was refractory to multiple urological interventions, which eventually necessitated an enteric diversion of the exocrine pancreas. Hematuria ceased following an uneventful postoperative course.
PMID: 19560858 [PubMed - as supplied by publisher]
Castration-resistant Prostate Cancer: From New Pathophysiology to New Treatment Targets. Chi KN, Bjartell A, Dearnaley D, Saad F, Schröder FH, Sternberg C, Tombal B, Visakorpi T
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Castration-resistant Prostate Cancer: From New Pathophysiology to New Treatment Targets.
Eur Urol. 2009 Jun 24;
Authors: Chi KN, Bjartell A, Dearnaley D, Saad F, Schröder FH, Sternberg C, Tombal B, Visakorpi T
CONTEXT: Castration-resistant prostate cancer (CRPC) refers to patients who no longer respond to surgical or medical castration. Standard treatment options are limited. OBJECTIVE: To review the concepts and rationale behind targeted agents currently in late-stage clinical testing for patients with CRPC. EVIDENCE ACQUISITION: Novel targeted therapies in clinical trials were identified from registries. The MEDLINE database was searched for all relevant reports published from 1996 to October 2009. Bibliographies of the retrieved articles and major international meeting abstracts were hand-searched to identify additional studies. EVIDENCE SYNTHESIS: Advances in our understanding of the molecular mechanisms underlying prostate cancer (PCa) progression has translated into a variety of treatment approaches. Agents targeting androgen receptor (AR) activation and local steroidogenesis, angiogenesis, immunotherapy, apoptosis, chaperone proteins, the insulin-like growth factor (IGF) pathway, RANK-ligand, endothelin receptors, and the Src family kinases are entering or have recently completed accrual to phase 3 trials for patients with CRPC. CONCLUSIONS: A number of new agents targeting mechanisms of PCa progression with early promising results are in clinical trials and have the potential to provide novel treatment options for CRPC in the near future.
PMID: 19560857 [PubMed - as supplied by publisher]
Mechanisms of Pelvic Floor Muscle Function and the Effect on the Urethra during a Cough. Lovegrove Jones RC, Peng Q, Stokes M, Humphrey VF, Payne C, Constantinou CE
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Mechanisms of Pelvic Floor Muscle Function and the Effect on the Urethra during a Cough.
Eur Urol. 2009 Jun 21;
Authors: Lovegrove Jones RC, Peng Q, Stokes M, Humphrey VF, Payne C, Constantinou CE
BACKGROUND: Current measurement tools have difficulty identifying the automatic physiologic processes maintaining continence, and many questions still remain about pelvic floor muscle (PFM) function during automatic events. OBJECTIVE: To perform a feasibility study to characterise the displacement, velocity, and acceleration of the PFM and the urethra during a cough. DESIGN, SETTING, AND PARTICIPANTS: A volunteer convenience sample of 23 continent women and 9 women with stress urinary incontinence (SUI) from the general community of San Francisco Bay Area was studied. MEASUREMENTS: Methods included perineal ultrasound imaging, motion tracking of the urogenital structures, and digital vaginal examination. Statistical analysis used one-tailed unpaired student t tests, and Welch's correction was applied when variances were unequal. RESULTS AND LIMITATIONS: The cough reflex activated the PFM of continent women to compress the urogenital structures towards the pubic symphysis, which was absent in women with SUI. The maximum accelerations that acted on the PFM during a cough were generally more similar than the velocities and displacements. The urethras of women with SUI were exposed to uncontrolled transverse acceleration and were displaced more than twice as far (p=0.0002), with almost twice the velocity (p=0.0015) of the urethras of continent women. Caution regarding the generalisability of this study is warranted due to the small number of women in the SUI group and the significant difference in parity between groups. CONCLUSIONS: During a cough, normal PFM function produces timely compression of the pelvic floor and additional external support to the urethra, reducing displacement, velocity, and acceleration. In women with SUI, who have weaker urethral attachments, this shortening contraction does not occur; consequently, the urethras of women with SUI move further and faster for a longer duration.
PMID: 19560261 [PubMed - as supplied by publisher]
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