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<title>Urology jobs</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs.html</link>
<description><![CDATA[All Urology jobs for Sat Feb  4 2012]]></description>
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<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_california/page_11.html">
<title>Urology jobs in &#x22;Riverside&#x22; - CA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_california/page_11.html</link>
<description><![CDATA[   Southwest Riverside County - located about 90 minutes from the Los Angeles Metro,     less than an hour from San Diego or Palm Springs and just 30 minutes to Riverside, Temecula, Hemet and Menifee ]]></description>
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<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_illinois/page_17.html">
<title>Urology jobs in &#x22;Peoria&#x22; - IL</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_illinois/page_17.html</link>
<description><![CDATA[ Recently you logged on to our website requesting information.  Currently a large client we represent is seeking 4 Urologists for different locations in Illinois.  They are known for being competitive ]]></description>
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<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kansas/page_8.html">
<title>Urology jobs in &#x22;South Central KRC.0309.1604.04&#x22; - KS</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kansas/page_8.html</link>
<description><![CDATA[ KRC.0309.1604.04   New position available for a urologist to be hospital employed or in a solo practice.  There are currently no other urologists on staff.  The hospital is a 69-bed acute care facility ]]></description>
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<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kansas/page_2.html">
<title>Urology jobs in &#x22;North Central KRC.0708.0701.13&#x22; - KS</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kansas/page_2.html</link>
<description><![CDATA[ KRC.0708.0701.13   Urologist  New position for a two-campus, 99 bed, regional acute care hospital.  The modern facility offers full laparoscopic system, family birthing rooms, a well-equipped intensive ]]></description>
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<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_washington/page_13.html">
<title>Urology jobs in &#x22;Urologist - Washington State&#x22; - WA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_washington/page_13.html</link>
<description><![CDATA[120125-1878 Urologist - Washington State WA     Seeking BC/BE Urologist for hospital employed position   J1/H1Bs welcome    Private practice/income guarantee also available   Fantastic location with nearly ]]></description>
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<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kansas/page_6.html">
<title>Urology jobs in &#x22;Southeast KRC.0909.1201.29C&#x22; - KS</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kansas/page_6.html</link>
<description><![CDATA[ KRC.0909.1201.29C   Urologist position available as hospital employed or independent.  This position is available in preparation for the current urologist's upcoming retirement in the next 2-3 years. ]]></description>
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<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kansas/page_3.html">
<title>Urology jobs in &#x22;Southwest KRC.0811.0401.15&#x22; - KS</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kansas/page_3.html</link>
<description><![CDATA[  KRC.0811.0401.15 &nbsp;&nbsp;  Urologist for multi-specialty group housing 25 physicians with 11 specialties. &nbsp;  There is a large service area with many referrals from the region. This group also ]]></description>
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<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kansas/page_4.html">
<title>Urology jobs in &#x22;Southeast KRC.0608.0305.09&#x22; - KS</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kansas/page_4.html</link>
<description><![CDATA[ KRC.0608.0305.09  Urologist position available for solo practice. The not-for-profit 105-bed operating admitting Medical Center provides the following services: acute care, skilled nursing, OB/GYN, ICU, ]]></description>
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<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kansas/page_5.html">
<title>Urology jobs in &#x22;Southeast KRC.0408.1406.02&#x22; - KS</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kansas/page_5.html</link>
<description><![CDATA[ Urologist position available for solo practice. The 190-bed admitting hospital provides full service general acute care including CT, ER, home health, hospice, ICU, MRI, nuclear medicine, ultrasound, ]]></description>
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<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_south_carolina/page_5.html">
<title>Urology jobs in &#x22;Urologist - South Carolina&#x22; - SC</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_south_carolina/page_5.html</link>
<description><![CDATA[111021-1778 Urologist - South Carolina SC     Seeking BC/BE urologist to join a local practice   You would be part of an established group with updated capabilites on site including: x-ray, CT scan, and ]]></description>
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<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_nevada/page_5.html">
<title>Urology jobs in &#x22;Urologist - Las Vegas, NV&#x22; - NV</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_nevada/page_5.html</link>
<description><![CDATA[110624-1597 Urologist - Las Vegas, NV NV     Seeking BC/BE urologist for new 171-bed facility   Solo start-up position   Hospital offers full financial support including income guarantee, practice expense, ]]></description>
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<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_new_york/page_4.html">
<title>Urology jobs in &#x22;Southwest of Cooperstown&#x22; - NY</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_new_york/page_4.html</link>
<description><![CDATA[   We have an outstanding opportunity located Southwest of Cooperstown,NY&nbsp;for a Urologist to join a large multi-specialty group.           &nbsp;        The outstanding practice staff includes an ]]></description>
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<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_tennessee/page_1.html">
<title>Urology jobs in &#x22;Urologist - Tennessee&#x22; - TN</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_tennessee/page_1.html</link>
<description><![CDATA[110126-1531 Urologist - Tennessee TN     Seeking BC/BE urologist for hospital employed opportunity at 247-bed facility   Work in expanding OR unit with well-trained staff and state-of-the-art equipment ]]></description>
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<title>Urology jobs in &#x22;Just South of Boston&#x22; - MA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_massachusetts/page_3.html</link>
<description><![CDATA[   BE/BC Urologist-Great opportunity in the greater Boston Area!! -2011 &amp; 2012 Grads Considered!!         Outstanding opportunity for a BE/BC Urologist in the greater Boston area. Client will consider ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_nevada/page_6.html">
<title>Urology jobs in &#x22;NorthEastern Nevada&#x22; - NV</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_nevada/page_6.html</link>
<description><![CDATA[   Excellent Urology Opportunity in Nevada    Compensation in the $400K -$425K     $100,000 Sign on Bonus           General Adult Urologist needed to replace outgoing physician in private practice. &nbsp;He ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_nevada/page_21.html">
<title>Urology jobs in &#x22;Inquire for details&#x22; - NV</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_nevada/page_21.html</link>
<description><![CDATA[Board Certified/Board Eligible Urologist needed for solo start-up opportunity.  Hospital offers full financial support including income guarantee, practice expense, start-up assistance, relocation and ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_north_carolina/page_14.html">
<title>Urology jobs in &#x22;Inquire for details&#x22; - NC</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_north_carolina/page_14.html</link>
<description><![CDATA[We are looking for a 3rd Urologist to join our other 2 physicians and 1 PA.  Client ID: 1233 Email: admin@jobs4med.com Web: www.jobs4med.com]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_california/page_27.html">
<title>Urology jobs in &#x22;Greater Sacramento&#x22; - CA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_california/page_27.html</link>
<description><![CDATA[ Our client in the Greater Sacramento area of CA is currently in need of a BC/BE Urgent Care Physician.   &nbsp;   Board Certified is preferred but Board Eligible will be accepted.   &nbsp;   California ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_arkansas/page_3.html">
<title>Urology jobs in &#x22;Urology - Arkansas&#x22; - AR</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_arkansas/page_3.html</link>
<description><![CDATA[110923-1747 Urology - Arkansas AR     Seeking BC/BE urologist to join department at 588-bed facility   Hospital employed position   Competitive compensation with excellent benefits package   Beautiful ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_oregon/page_2.html">
<title>Urology jobs in &#x22;Close to Portland&#x22; - OR</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_oregon/page_2.html</link>
<description><![CDATA[ EXCELLENT UROLOGY OPPORTUNITY ~ SOUTHERN OREGON  Population 25,000 With a Service Area of 100,000 Beautiful Area offering a Great Quality of Life and less than an hour to Portand  This 130 bed state ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kentucky/page_9.html">
<title>Urology jobs in &#x22;Call for location&#x22; - KY</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kentucky/page_9.html</link>
<description><![CDATA[Outpatient Medicine Opportunity for Primary Care Physician near Lexington, KY.  Primary Care outpatient only with Light Call. Full-time regular sick call. Full-time long-term locums. Permanent placement ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_california/page_15.html">
<title>Urology jobs in &#x22;Greater Las Vegas&#x22; - CA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_california/page_15.html</link>
<description><![CDATA[             We have a great opportunity for you to start-up your own practice in a growing community as a BC/BE Urologist located in the Greater Las Vegas, NV area.             &nbsp;        Board Certified ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_new_york/page_28.html">
<title>Urology jobs in &#x22;Greater Alleghany&#x22; - NY</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_new_york/page_28.html</link>
<description><![CDATA[    Excellent Permanent Urology Opportunity in Greater Alleghany, NY area.        &nbsp;   BC/BE       Hospital Employee       Immediate Opening       Call rotation: 1/2 - 1/3       Monday - Friday work ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_texas/page_3.html">
<title>Urology jobs in &#x22;McAllen/Edinburg&#x22; - TX</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_texas/page_3.html</link>
<description><![CDATA[Employed Urology Opportunity - Texas   South Texas Health System is recruiting a new Urologist to the communities of McAllen and Edinburg.    The Urologist will have the option of being employed by the ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_alaska/page_1.html">
<title>Urology jobs in &#x22;85K Population&#x22; - AK</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_alaska/page_1.html</link>
<description><![CDATA[ Excellent opportunity for a Urologist in Alaska's largest city.  85K population.  There is a strong need in the community for a new physician. Incoming physician will have the option to join an existing ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_iowa/page_1.html">
<title>Urology jobs in &#x22;Iowa Locations&#x22; - IA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_iowa/page_1.html</link>
<description><![CDATA[ Excellent opportunity to join a large, well known healthcare system that has over 100 providers in 14 different Iowa locations, both metro and rural.  This opportunity is in a pop. of 75,000. Hospital ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_texas/page_20.html">
<title>Urology jobs in &#x22;Corpus Christi&#x22; - TX</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_texas/page_20.html</link>
<description><![CDATA[   UROLOGY Opportunity in Corpus Christi, Texas!         &nbsp;   OPPORTUNITY:&nbsp; This 8 Urology practitioner team has cared for patients on the Texas Gulf Coast for over 30 years.&nbsp; Their commitment ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_california/page_29.html">
<title>Urology jobs in &#x22;Great Location&#x22; - CA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_california/page_29.html</link>
<description><![CDATA[Full Time Locums Urologist needed for clinic and call in CA.   This position starts ASAP!!! Mon-Thur Clinic (Fri is OR/Surg Day) with call 1:3. There will be 20-22 patients per day. Typical procedures ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_washington/page_3.html">
<title>Urology jobs in &#x22;Great Location&#x22; - WA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_washington/page_3.html</link>
<description><![CDATA[Very Lucrative Permanent Opportunity for a Urologist in Washington State.   Are you looking for a Great work life balance? If so, This opportunity has a call rotation of 1:4 and will give you plenty of ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_west_virginia/page_6.html">
<title>Urology jobs in &#x22;Not Disclosed&#x22; - WV</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_west_virginia/page_6.html</link>
<description><![CDATA[A medical center in southwest West Virginia seeks a permanent, BC (or BE working towards BC) Urologist to begin as soon as possible. The current part-time Urologist is nearing retirement and the community ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_arizona/page_1.html">
<title>Urology jobs in &#x22;NW of Phoenix&#x22; - AZ</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_arizona/page_1.html</link>
<description><![CDATA[   An excellent opportunity exists NW of Phoenix, AR for a BC/BE Urologist to join a hospital-owned clinic.           &nbsp;        Board Certified is preferred but Board Eligible will be accepted.   ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_georgia/page_11.html">
<title>Urology jobs in &#x22;Not Disclosed&#x22; - GA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_georgia/page_11.html</link>
<description><![CDATA[Our client in central Georgia seeks to hire a permanent Urologist for their facility. Candidates can be Board Certified or Board Eligible in Urology. The facility employs over 30 outstanding physicians ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_nevada/page_12.html">
<title>Urology jobs in &#x22;Not Disclosed&#x22; - NV</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_nevada/page_12.html</link>
<description><![CDATA[Our client in the North Eastern part of Nevada seeks to hire a permanent Urologist. Candidates can be Board Certified or Board Eligible in Urology and MD's, DO's, FMG's and Visa's are acceptable candidates. ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_florida/page_6.html">
<title>Urology jobs in &#x22;Jacksonville&#x22; - FL</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_florida/page_6.html</link>
<description><![CDATA[  Urologists Needed in Orange Park, FL!     We are seeking Urologists interested in being in an employed group in Orange Park, Florida! Great compensation and benefits package!     Orange Park, Florida ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_georgia/page_16.html">
<title>Urology jobs in &#x22;Cartersville&#x22; - GA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_georgia/page_16.html</link>
<description><![CDATA[   Great Employed Position!         &nbsp;     Great new Urology opportunity for a&nbsp;BC/BE Urologist.&nbsp;Cartersville Medical Center has a new&nbsp;DiVinci Robot!       This will be a new HCA Employed ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kentucky/page_10.html">
<title>Urology jobs in &#x22;Hopkinsville&#x22; - KY</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kentucky/page_10.html</link>
<description><![CDATA[  Ideal Location     Explore our thriving and charming community - an outstanding place to raise a family and simply enjoy life. With easy access to Nashville, never be far from big-city entertainment ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_pennsylvania/page_3.html">
<title>Urology jobs in &#x22;West/Central&#x22; - PA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_pennsylvania/page_3.html</link>
<description><![CDATA[ We have an outstanding opportunity for you to come join a hospital based practice in the West/Central area of PA as a BC/BE Urologist.   &nbsp;   Board Certified is preferred but Board Eligible will ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_pennsylvania/page_9.html">
<title>Urology jobs in &#x22;West/Central&#x22; - PA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_pennsylvania/page_9.html</link>
<description><![CDATA[ We have an outstanding opportunity for you to come join a hospital based practice in the West/Central area of PA as a BC/BE Urologist.   &nbsp;   Board Certified is preferred but Board Eligible will ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_south_carolina/page_7.html">
<title>Urology jobs in &#x22;Myrtle Beach&#x22; - SC</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_south_carolina/page_7.html</link>
<description><![CDATA[      We have an excellent opportunity for a BC/BE Urologist in the Myrtle Beach area of South Carolina.            &nbsp;         Board Certified is preferred but Board Eligible will be accepted.    ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_indiana/page_7.html">
<title>Urology jobs in &#x22;Southwestern&#x22; - IN</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_indiana/page_7.html</link>
<description><![CDATA[   Well-established Urology group in Southwestern Indiana is seeking a full time BC/BE Urologist to join their practice, performing all aspects of inpatient and outpatient services. Excellent opportunity ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_california/page_22.html">
<title>Urology jobs in &#x22;UR/ONC 18765&#x22; - CA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_california/page_22.html</link>
<description><![CDATA[   SOUTHERN CALIFORNIA UROLOGICAL ONCOLOGY ROBOTIC SURGERY    JOIN AN AWARD WINNING CANCER CENTER WITH ACCESS TO A ROBOTIC SURGICAL SYSTEM Practice in Southern California in a NON SATURATED MARKET Extremely ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_georgia.html">
<title>Urology jobs in Georgia</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_georgia.html</link>
<description><![CDATA[All Urology jobs in Georgia for Sat Feb  4 2012]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_florida/page_16.html">
<title>Urology jobs in &#x22;Miami Beach&#x22; - FL</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_florida/page_16.html</link>
<description><![CDATA[                   Physician Needed for New Mens Clinic in Miami Beach       &nbsp;        Miami Male Medical Clinic has an opportunity for a General Practitioner, Urologist, Physician Assistant or other ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kentucky/page_5.html">
<title>Urology jobs in &#x22;Williamson&#x22; - KY</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kentucky/page_5.html</link>
<description><![CDATA[ Williamson ARH Hospital  BC/BE Urologist   Williamson ARH Hospital is seeking a BC/BE Urologist to join its medical staff. Our 163-bed community hospital prides itself with a high tech-high touch approach ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_indiana/page_5.html">
<title>Urology jobs in &#x22;Fort Wayne&#x22; - IN</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_indiana/page_5.html</link>
<description><![CDATA[     A multi-specialty group in Greater Fort Wayne, IN is looking to bring on a BC/BE Urologist           &nbsp;       Board Certified is preferred but Board Eligible will be accepted.         &nbsp; ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_indiana/page_18.html">
<title>Urology jobs in &#x22;Ft. Wayne&#x22; - IN</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_indiana/page_18.html</link>
<description><![CDATA[Lutheran Hospital in Fort Wayne is seeking to recruit a BC/BE Urologist who is trained in robotics.Some fundamentals of the opportunity include the availbility of the DaVinci Robot, Prostate Cancer Center, ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_indiana/page_17.html">
<title>Urology jobs in &#x22;Massillon&#x22; - IN</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_indiana/page_17.html</link>
<description><![CDATA[Fort Wayne-St. Joseph Hospital is seeking a board certified/board eligible urologist to join our multi-specialty group. Within the Lutheran Health Network there is a prostate cancer and research center, ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_tennessee/page_10.html">
<title>Urology jobs in &#x22;Kingsport&#x22; - TN</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_tennessee/page_10.html</link>
<description><![CDATA[ Employer Information: Four man group with need for a replacement for a retiring partner. A fifth Urologist is also under consideration. Located in a community of 45,000 (450,000 Tri-Cities Metro Area) ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_tennessee/page_9.html">
<title>Urology jobs in &#x22;Nashville&#x22; - TN</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_tennessee/page_9.html</link>
<description><![CDATA[                   Physician Needed for Established Mens Clinic in Nashville       &nbsp;        Nashville Male Medical Clinic has an opportunity for a General Practitioner, Urologist, Physician Assistant ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_pennsylvania/page_19.html">
<title>Urology jobs in &#x22;Allentown&#x22; - PA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_pennsylvania/page_19.html</link>
<description><![CDATA[    UROLOGISTS            GENERALISTS and SUBSPECIALISTS            &nbsp;         We are searching for BC/BE urologists to join three other well-trained urologists in a network-owned practice. We will ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_new_york/page_13.html">
<title>Urology jobs in &#x22;Alleghany&#x22; - NY</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_new_york/page_13.html</link>
<description><![CDATA[Outstanding opportunity available for a Permanent BE/BC Urologist in the Greater Allegany, NY area.  &nbsp;  Weekday call - 1:3  &nbsp;  Great Compensation!  &nbsp;  Sign-on Bonus!  &nbsp;  Great benefits, ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_south_carolina/page_3.html">
<title>Urology jobs in &#x22;SouthEast&#x22; - SC</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_south_carolina/page_3.html</link>
<description><![CDATA[BC Urologist for a hospital employed position.  This position is available immediately and will include a full range of benefits, including relocation assistance, paid CME and medical education debt repayment ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_florida/page_27.html">
<title>Urology jobs in &#x22;Pop. 13K&#x22; - FL</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_florida/page_27.html</link>
<description><![CDATA[ Excellent Urology Opportunity in Florida.   Solo or group practice availability Within two hours of the Gulf of Mexico, Atlantic Ocean, and Orlando.  Growing Community with a strong need and NO Competition ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_indiana/page_6.html">
<title>Urology jobs in &#x22;Bluffton&#x22; - IN</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_indiana/page_6.html</link>
<description><![CDATA[Bluffton Regional Medical Center seeks to recruit a BC/BE Urologist to join it's team! The right candidate will rotate between two offices serving Bluffton Regional and Dukes Memorial hospitals. This ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_hawaii/page_1.html">
<title>Urology jobs in &#x22;Honolulu&#x22; - HI</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_hawaii/page_1.html</link>
<description><![CDATA[                   Physician or PA.&nbsp; Immediate Opening.         &nbsp;        Hawaii Male Medical Clinic has an opportunity for a General Practitioner, Urologist, Physician Assistant or other M.D. ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_wyoming/page_1.html">
<title>Urology jobs in &#x22;Gillette&#x22; - WY</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_wyoming/page_1.html</link>
<description><![CDATA[ Wyoming Urology Opportunity   Gillette- Excellent opportunities for (BE/BC) Urology surgeon, to provide care in busy practice in beautiful, Gillette, Wyoming. Fantastic salary, benefits and good call. ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_ohio/page_8.html">
<title>Urology jobs in &#x22;Sandusky&#x22; - OH</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_ohio/page_8.html</link>
<description><![CDATA[ Executive Urology, a three member, busy urology practice is seeking a motivated BE/BC urologist to join their practice in a progressive medical community in North Central Ohio. This position offers a ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_california/page_10.html">
<title>Urology jobs in &#x22;Southern&#x22; - CA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_california/page_10.html</link>
<description><![CDATA[   We know of a well-established, very busy private practice in Southern California that is looking to bring on a BC/BE Urologist to join their group.           &nbsp;        Board Certified is preferred ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_texas/page_26.html">
<title>Urology jobs in &#x22;Southern&#x22; - TX</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_texas/page_26.html</link>
<description><![CDATA[             We have a great opportunity available in the Southern tip of Texas for a BC/BE Urologist.            &nbsp;        Board Certified is preferred but Board Eligible will be accepted.       ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_maine/page_16.html">
<title>Urology jobs in &#x22;Northern&#x22; - ME</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_maine/page_16.html</link>
<description><![CDATA[   A busy established practice with an extensive referral base in the Northern area of Maine is seeking a BC/BE Urologist to join their group.          &nbsp;       Board Certified is preferred but Board ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_new_york/page_18.html">
<title>Urology jobs in &#x22;Syracuse&#x22; - NY</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_new_york/page_18.html</link>
<description><![CDATA[   We have a well-established independent group in the Syracuse area of NY that is seeking a permanent Urologist to join their group.          &nbsp;       Ideal candidate will have training in women's ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_california/page_17.html">
<title>Urology jobs in &#x22;UR122624&#x22; - CA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_california/page_17.html</link>
<description><![CDATA[ NORTHERN CALIFORNIA UROLOGY ROBOT AVAILABLE   JOIN AN ESTABLISHED AND TECHNOLOGICALLY ADVANCED UROLOGY GROUP.      100% hospital and community support. Make an impact in the community  you will be the ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_tennessee/page_11.html">
<title>Urology jobs in &#x22;Bristol&#x22; - TN</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_tennessee/page_11.html</link>
<description><![CDATA[Bristol Regional Medical Center, a member of the Wellmont Health System, and Johnson City Urological Clinic, P.C. is seeking a Urologist to join their practice in Bristol, TN.  Johnson City Urological ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_washington/page_8.html">
<title>Urology jobs in &#x22;Spokane&#x22; - WA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_washington/page_8.html</link>
<description><![CDATA[ Spokane, Washington  Providence Health &amp; Services and an established single-specialty private practice are partnering to bring a new BE/BC Urologist to serve this sunny eastern Washington community. ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_west_virginia/page_8.html">
<title>Urology jobs in &#x22;Beckley&#x22; - WV</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_west_virginia/page_8.html</link>
<description><![CDATA[ Beckley ARH Hospital  Urologist   Beckley ARH Hospital is seeking a Urologist to join its medical staff. Our 173-bed community hospital prides itself with a high tech-high touch approach to medicine ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_washington/page_4.html">
<title>Urology jobs in &#x22;Spokane&#x22; - WA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_washington/page_4.html</link>
<description><![CDATA[Rockwood Clinic seeks a BE or BC general Urologist addition for their busy and expanding clinic. The group consists of three Urologist and two Non-Physician Providers. This is an excellent opportunity ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_oregon/page_1.html">
<title>Urology jobs in &#x22;Oregon&#x22; - OR</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_oregon/page_1.html</link>
<description><![CDATA[ I am working with an Oregon multi-specialty group that is adding another Urologist to their clinic. The current Urologist has a large practice is in need of a partner. The opportunity for a specialist ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kentucky/page_19.html">
<title>Urology jobs in &#x22;Hazard&#x22; - KY</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kentucky/page_19.html</link>
<description><![CDATA[ Hazard ARH Hospital  BC/BE Urologist   Hazard ARH Regional Medical Center is seeking a BC/BE Urologist to join its medical staff. Our 308-bed regional medical center prides itself with a high tech-high ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kentucky/page_14.html">
<title>Urology jobs in &#x22;Harlan&#x22; - KY</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_kentucky/page_14.html</link>
<description><![CDATA[ Harlan ARH Hospital  BC/BE Urologist   Harlan ARH Hospital is seeking a BC/BE Urologist to join its medical staff. Our 150-bed community hospital prides itself with a high tech-high touch approach to ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_maine/page_1.html">
<title>Urology jobs in &#x22;Bangor&#x22; - ME</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_maine/page_1.html</link>
<description><![CDATA[  Urology-Maine-Physician needed-     BC/BE Urologist to join 5 others in this hospital-employed practice. We offer a competitive salary with full benefits including health insurance, 403b retirement ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_massachusetts/page_5.html">
<title>Urology jobs in &#x22;Boston&#x22; - MA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_massachusetts/page_5.html</link>
<description><![CDATA[   Exciting Opportunity for an Urologist in a Suburb of Boston!&nbsp;      You&rsquo;ll  join a successful private practice  with five other BC Urologists. This is a &ldquo;bread and butter&rdquo; urology ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_massachusetts/page_11.html">
<title>Urology jobs in &#x22;Boston&#x22; - MA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_massachusetts/page_11.html</link>
<description><![CDATA[ We have a great opportunity available in the Boston area of MA for a Urologist. Client is looking for someone with current training as it relates to surgery.       BC/BE      EMR      AMG Required   ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_new_york/page_25.html">
<title>Urology jobs in &#x22;Albany&#x22; - NY</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_new_york/page_25.html</link>
<description><![CDATA[   Excellent Permanent Urology Opportunity in Albany, NY   &nbsp;   Opportunity is to join a private Urology group that rounds on 2 hospitals   -Weekday call  1:3   -Weekend call  1:7   -Base guarantee ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_oregon/page_8.html">
<title>Urology jobs in &#x22;Oregon&#x22; - OR</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_oregon/page_8.html</link>
<description><![CDATA[I have 2 hospitals in Oregon seeking full time urologists.  1-3 year income guarantee, med mal paid for, great benefits and a relocation bonus are only some of the highlights.  Please contact me at 877-706-4949 ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_nevada/page_18.html">
<title>Urology jobs in &#x22;Elko&#x22; - NV</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_nevada/page_18.html</link>
<description><![CDATA[      Excellent Opportunity for a Urologist ~ Facility is owned by a large Healthcare System that is always competitive and capable of working quickly.&nbsp;                    General Adult Urologist ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_arizona/page_5.html">
<title>Urology jobs in &#x22;Yuma&#x22; - AZ</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_arizona/page_5.html</link>
<description><![CDATA[ BC/BE Urologist sought for beautiful Arizona!!  Excellent opportunity to establish a Urology practice in a location that will allow you to build your practice rapidly due to the strong need. Option to ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_utah/page_5.html">
<title>Urology jobs in &#x22;Utah&#x22; - UT</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_utah/page_5.html</link>
<description><![CDATA[ Urology - This has a wide open market and there is more than enough volume to support a full time Urologist.  The person could either set up a 100% owned hospital practice. We need a general adult urologist. ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_north_carolina/page_1.html">
<title>Urology jobs in &#x22;West&#x22; - NC</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_north_carolina/page_1.html</link>
<description><![CDATA[BC/BE Urologist to join a multi-specialty surgical group. Candidate will serve a full range of patients with urological symptoms. Private practice  model with start-up assistance and forgiveness from ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_virginia/page_23.html">
<title>Urology jobs in &#x22;East&#x22; - VA</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_virginia/page_23.html</link>
<description><![CDATA[BC/BE Urologist for hospital employment.  Compensation package will be commensurate with training and experience.  This is an excellent opportunity for experienced physicians, as well as Residents!   ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_idaho/page_7.html">
<title>Urology jobs in &#x22;ID&#x22; - ID</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_idaho/page_7.html</link>
<description><![CDATA[ A large MSG is adding a Urology department. This will be a startup department with a 1 in 4 call rotation. The clinic is offering an excellent benefit package with 15% employer paid retirement plan contribution ]]></description>
</item>

<item rdf:about="http://www.physemp.com/physician_jobs/perma_urology_jobs_in_texas/page_1.html">
<title>Urology jobs in &#x22;&#x22; - TX</title>
<link>http://www.physemp.com/physician_jobs/perma_urology_jobs_in_texas/page_1.html</link>
<description><![CDATA[Exciting new opportunity in the Heart of TX.  This hospital is looking to fill 3 urology positions, 2 immediately.  Following are just a few of the exciting highlights of this wonderful opportunity:  ]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/241110.php">
<title>In Preadolescence, Sleep Deprivation Tied To Increased Nighttime Urination</title>
<link>http://www.medicalnewstoday.com/releases/241110.php</link>
<description><![CDATA[Nighttime visits to the bathroom are generally associated with being pregnant or having an enlarged prostate, but the problem can affect youngsters, too. A new study sheds light on why some children may need to urinate more often during the rest cycle...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/241125.php">
<title>For Kidney Disease Patients, Goals For Blood Pressure May Be Unrealistic</title>
<link>http://www.medicalnewstoday.com/releases/241125.php</link>
<description><![CDATA[An upward revision of the blood pressure numbers used to identify risk of end-stage renal disease (ESRD) might actually help doctors provide better care for their patients, said the authors of a study in patients with chronic kidney disease (CKD). The researchers found that systolic blood pressure - the "upper number" in a blood pressure reading - was the key variable...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/articles/241113.php">
<title>Bedwetting Linked To Constipation In Children</title>
<link>http://www.medicalnewstoday.com/articles/241113.php</link>
<description><![CDATA[A study by Wake Forest Baptist Medical Center reveals that the cause for bedwetting is often constipation, and not always bladder problems. If left undiagnosed, bedwetting can be an unnecessarily long, expensive and difficult challenge to cure. The study is published online in the journal Urology...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/241027.php">
<title>Space Researchers Develop Ultrasound Technology That Detects, Treats Kidney Stones</title>
<link>http://www.medicalnewstoday.com/releases/241027.php</link>
<description><![CDATA[Just the mention of kidney stones can cause a person to cringe. They are often painful and sometimes difficult to remove, and 10 percent of the population will suffer from them. In space, the risk of developing kidney stones is exacerbated due to environmental conditions. The health risk is compounded by the fact that resource limitations and distance from Earth could restrict treatment options...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/241005.php">
<title>Improved Kidney Transplant Survival In Mice; New Agent  Likely To Speed Replacement Of Other Organs</title>
<link>http://www.medicalnewstoday.com/releases/241005.php</link>
<description><![CDATA[New research published online in the FASEB Journal details a new antibody, called "OPN-305" that may significantly improve survival outcomes for those receiving donated kidneys and other organs. OPN-305 works by preventing inflammation triggered by oxygen deprivation in the donated organ, allowing for better recovery after transplantation...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/240920.php">
<title>Research Shows Bedwetting Can Be Due To Undiagnosed Constipation</title>
<link>http://www.medicalnewstoday.com/releases/240920.php</link>
<description><![CDATA[Bedwetting isn't always due to problems with the bladder, according to new research by Wake Forest Baptist Medical Center. Constipation is often the culprit; and if it isn't diagnosed, children and their parents must endure an unnecessarily long, costly and difficult quest to cure nighttime wetting...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/articles/240941.php">
<title>Cerebral Palsy Linked With Genetic Abnormalities</title>
<link>http://www.medicalnewstoday.com/articles/240941.php</link>
<description><![CDATA[ Researchers at Geisinger Health System have found that genetic abnormalities may be the cause for the majority of cerebral palsy (CP) cases, a group of disorders that can involve the brain and nervous system functions, such as seeing, movement, hearing, thinking, and learning, rather than a difficult birth or other perinatal factors. CP is the most prevalent physical disability of childhood...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/240831.php">
<title>Stopping Immunosuppressive Prednisone Soon After Transplantation Found To Be Safe</title>
<link>http://www.medicalnewstoday.com/releases/240831.php</link>
<description><![CDATA[Rapid discontinuation of the immunosuppressive steroid prednisone after a kidney transplant can help prevent serious side effects, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). Also, doing so does not appear to jeopardize the long-term survival of transplant patients and their new organs...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/articles/240892.php">
<title>Inlyta (axitinib) Approved For Advanced Kidney Cancer, USA</title>
<link>http://www.medicalnewstoday.com/articles/240892.php</link>
<description><![CDATA[The US FDA has approved Inlyta (axitinib) for the treatment of advanced renal cell carcinoma, a type of kidney cancer, in patients with whom other drugs have not been effective, the FDA (Food and Drug Administration) announced today. Inlyta is made and marketed by pharmaceutical giant Pfizer Inc...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/240737.php">
<title>Better Treatment And Fewer Costs With New Detection Method For UTI-Causing Bacteria</title>
<link>http://www.medicalnewstoday.com/releases/240737.php</link>
<description><![CDATA[A new method for identifying bacteria that cause urinary tract infections (UTIs) will lead to much faster, more effective treatment as well as a reduction in costs. The procedure, described in the Journal of Medical Microbiology, could eventually be used for the identification of micro-organisms in other bodily fluids, including blood and spinal fluid...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/articles/240752.php">
<title>Dutasteride Slows Down Early Stage Prostate Cancer Progression</title>
<link>http://www.medicalnewstoday.com/articles/240752.php</link>
<description><![CDATA[A study published Online First in The Lancet has found that a common medication (dutasteride) used to treat enlargement of the prostate, may also reduce the need for treatments that pose risks of incontinence and impotence and delay growth of early-stage prostate cancer...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/240717.php">
<title>News From The Journal Of Clinical Investigation: Jan. 24, 2012</title>
<link>http://www.medicalnewstoday.com/releases/240717.php</link>
<description><![CDATA[ NEPHROLOGY: Understanding acute kidney injury to identify potential therapeutics  Acute kidney injury (AKI) is a life-threatening condition that frequently complicates the care of hospitalized patients. There are no specific therapies to treat AKI other than kidney replacement therapies such as dialysis...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/240687.php">
<title>Blood Levels Of Lead May Increase Smokers&#x27; Risk For Kidney Cancer</title>
<link>http://www.medicalnewstoday.com/releases/240687.php</link>
<description><![CDATA[Higher than normal levels of lead in the blood may signal a risk two times higher than average of developing renal cell carcinoma in smokers, according to medical researchers. "Past studies (in cadavers) have shown that, compared with kidneys from individuals without cancer, kidneys from individuals with cancer have higher lead levels," said Emily B...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/240657.php">
<title>How Salt, Potassium Levels Are Moderated Revealed By Study Of Rare Kidney Disease</title>
<link>http://www.medicalnewstoday.com/releases/240657.php</link>
<description><![CDATA[High blood pressure (hypertension) is a principal risk factor for heart disease and affects 1 billion people. At least half of them are estimated to be salt-sensitive; their blood pressure rises with sodium intake. New research shows important aspects of how sodium and potassium are regulated in the kidney...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/240548.php">
<title>New Drug Labels For Kidney Disease Patients</title>
<link>http://www.medicalnewstoday.com/releases/240548.php</link>
<description><![CDATA[The U.S. Food and Drug Administration (FDA) recently recommended that clinicians be more conservative when they prescribe chronic kidney disease (CKD) patients with drugs that treat red blood cell deficiencies. But the drug label's recommendations fall short, according to two commentaries appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN)...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/240549.php">
<title>TNF Receptor Levels In The Blood Warn Of Kidney Problems For Individuals With Type 1 And Type 2 Diabetes</title>
<link>http://www.medicalnewstoday.com/releases/240549.php</link>
<description><![CDATA[Levels of certain blood proteins indicate which diabetes patients will likely develop life-threatening kidney problems in the future, according to two studies appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The results could help physicians protect the kidney health of patients with diabetes years before any visible signs of trouble arise...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/240550.php">
<title>Kidney Failure, Gastrointestinal Bleeding And Dialysis</title>
<link>http://www.medicalnewstoday.com/releases/240550.php</link>
<description><![CDATA[Bleeding in the upper gastrointestinal (GI) tract causes serious health problems - and even early deaths - for many patients with kidney failure, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The findings indicate that greater efforts are needed to prevent and treat upper GI bleeding in these patients...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/240475.php">
<title>Genetic Code Cracked For A Devastating Blood Parasite</title>
<link>http://www.medicalnewstoday.com/releases/240475.php</link>
<description><![CDATA[Scientists have cracked the genetic code and predicted some high priority drug targets for the blood parasite Schistosoma haematobium, which is linked to bladder cancer and HIV/ AIDS and causes the insidious urogenital disease schistosomiasis haematobia in more than 112 million people in Africa...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/240514.php">
<title>Important Role In Acute, Chronic Urinary Tract Infections May Be Played By Bacterial Toxin</title>
<link>http://www.medicalnewstoday.com/releases/240514.php</link>
<description><![CDATA[Researchers from the University of Utah have identified a process by which the most common types of urinary tract infection-causing bacteria are able to trigger bladder cell shedding and disable immune responses. According to this new study, published in Cell Host & Microbe, Î±-hemolysin, a toxin secreted by many strains of Escherichia coli (E...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/240453.php">
<title>Researchers Identify Modifiable Risk Factors That Could Limit The Incidence Of Post-Transplant End-Stage Renal Disease</title>
<link>http://www.medicalnewstoday.com/releases/240453.php</link>
<description><![CDATA[Research from the University of Michigan Health System shows the risk for kidney failure among liver transplant recipients is higher following the implementation of Model of End Stage Liver Disease (MELD), a policy change in 2002 that altered how liver transplant allocation is decided. The study, led by Pratima Sharma, M.D., M.S...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/articles/240483.php">
<title>Stopping Prostate Cancer Growth - Breakthrough</title>
<link>http://www.medicalnewstoday.com/articles/240483.php</link>
<description><![CDATA[ A study by investigators at the Methodist Research Institute at Indiana University confirms that an all-natural, doctor-designed formula is effective in suppressing prostate cancer tumors. The study conducted on mice, used a human prostate cancer xenograft model. Results from the live animal study were presented by lead researcher, Dr...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/240415.php">
<title>News From The Journal Of Clinical Investigation: Jan. 17, 2012</title>
<link>http://www.medicalnewstoday.com/releases/240415.php</link>
<description><![CDATA[ VIROLOGY: How to prevent hepatitis B virus reproducing  Infection with hepatitis B virus (HBV) is a major health problem worldwide, despite the fact that a highly effective preventative vaccine exists. A modified form of the immune molecule IFN-alpha is commonly used to treat individuals infected with HBV...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/240389.php">
<title>New Biomarkers Tested  For Rapid Diagnosis Of Severe Kidney Damage</title>
<link>http://www.medicalnewstoday.com/releases/240389.php</link>
<description><![CDATA[How does a doctor determine whether or not an emergency-room patient has acute kidney injury? Using tests currently available in the hospital, this question is often difficult to answer. In many emergency cases, however, early diagnosis of the severity of the disease picture is crucial...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/releases/240402.php">
<title>Bladder Cancer Marker Identified By Computer Algorithm</title>
<link>http://www.medicalnewstoday.com/releases/240402.php</link>
<description><![CDATA[Researchers at the Stanford University School of Medicine have used an innovative mathematical technique to find markers that effectively predict how deadly a cancer will be. The discovery, which in this case concerned bladder cancer, could lead to faster, less expensive and more accurate analysis of cancer risk and better treatment of the disease...]]></description>
</item>

<item rdf:about="http://www.medicalnewstoday.com/articles/240390.php">
<title>Nurse Donates Own Kidney To Patient</title>
<link>http://www.medicalnewstoday.com/articles/240390.php</link>
<description><![CDATA[Nurse Allison Batson donated one of her own kidneys to 23-year old patient, Clay Taber; somebody she barely knew, after working on the transplant department of Emory University Hospital for over two years. Allison was not even Clay's primary nurse, but says she felt an instant connection with him. Taber, from Columbus, Ga...]]></description>
</item>

<item rdf:about="http://www.biomedcentral.com/1471-2490/12/2">
<title>Treatment of obstructive uropathy in one of three young brothers suffering from Gorlin - Cohen syndrome: a case report</title>
<link>http://www.biomedcentral.com/1471-2490/12/2</link>
<description><![CDATA[Background:
Frontometaphyseal dysplasia, or Gorlin-Cohen syndrome, is an X-linked disorder primarily characterized by skeletal dysplasia, such as hyperostosis of the skull and abnormalities of tubular bone modeling. Some patients develop extraskeletal manifestations, such as urinary tract anomalies.Case presentationA 26-year-old male patient was diagnosed with frontometaphyseal dysplasia and suffered from chronic urine retention. Although the patient was primarily diagnosed with a neurogenic bladder, our work-up revealed posterior urethral valves, bladder neck stenosis, and multiple bladder stones. The patient was treated by transurethral resection of the urethral valves and bladder neck with simultaneous open cystolithotomy to remove the bladder calculi. After removal of the catheter, the patient voided normally and had no post-void residual urine. At the 1-year follow-up, he was still voiding normally; his urodynamic investigation was also normal.
Conclusions:
In the recent literature, there is scarce information on the diagnosis, treatment, and follow-up of patients with malformations of the urinary tract as a result of Gorlin-Cohen syndrome. The case presented here could guide urological approaches to patients suffering from this rare condition.]]></description>
</item>

<item rdf:about="http://www.biomedcentral.com/1471-2490/12/1">
<title>Expression of apoptosis-regulating genes in the rat prostate following botulinum toxin type A injection</title>
<link>http://www.biomedcentral.com/1471-2490/12/1</link>
<description><![CDATA[Background:
Onabotulinumtoxin A (OnabotA) injection has been investigated as a novel treatment for benign prostatic enlargement caused by benign prostatic hyperplasia. An OnabotA - induced volume reduction caused by sympathetic fibers impairment has been proposed as a potential mechanism of action. Our aim was to investigate the expression of apoptosis-regulating proteins in the rat prostate following OnabotA intraprostatic injection.
Methods:
Adult Wistar rats were injected in the ventral lobes of the prostate with 10 U of OnabotA or saline. A set of OnabotA-injected animals was further treated with 0.5 mg/kg of phenylephrine (PHE) subcutaneously daily. All animals were sacrificed after 1 week and had their prostates harvested. Immunohistochemical staining was performed for Bax, Bcl-xL and caspase-3 proteins and visualized by the avidin-biotin method. The optical density of the glandular cells was also determined, with measurement of differences between average optical densities for each group.
Results:
Saline-treated animals showed intense epithelial staining for Bcl-xL and a faint labelling for both Bax and Caspase-3. OnabotA-treated rats showed a reduced epithelial staining of Bcl-xL and a consistently increased Bax and Caspase-3 staining when compared with saline-treated animals. PHE-treated animals showed a stronger Bcl-xL staining and reduced staining of both Bax and Caspase-3 when compared to the OnabotA group. Mean signal intensity measurements for each immunoreaction confirmed a significant decrease of the signal intensity for Bcl-xL and a significant increase of the signal intensity for Bax and Caspase 3 in OnabotA-injected animals when compared with the control group. In OnabotA+PHE treated animals mean signal intensity for Bcl-xL, Bax and Caspase 3 immunoreactions was identical to that of the control animals.
Conclusions:
These results support the hypothesis that OnabotA activates apoptotic pathways in the rat prostate through a mechanism that involves sympathetic outflow impairment.]]></description>
</item>

<item rdf:about="http://www.biomedcentral.com/1471-2490/11/26">
<title>Treatment of upper urinary tract stones with extracorporeal shock wave lithotripsy (ESWL) Sonolith vision</title>
<link>http://www.biomedcentral.com/1471-2490/11/26</link>
<description><![CDATA[Background:
The aim was to retrospectively assess the results of treatment of upper urinary tract stones with the Sonolith vision manufactured by EDAP, and purchased in 2004.
Methods:
The subjects were 226 Japanese patients who underwent extracorporeal shock wave lithotripsy (ESWL) alone as an initial treatment and could be followed up for at least 3 months, selected from 277 candidate patients who underwent this therapy between 2004 and 2006. Treatment effect was evaluated by kidney, ureter, and bladder X-ray or renal ultrasonography at 1 and 3 months after treatment. A stone-free status or status of stone fragmentation to 4 mm or smaller was considered to indicate effective treatment.
Results:
At 3 months after treatment, the stone-free rate was 69.4% and the efficacy rate was 77.4% for renal stones, while these rates were 91.5 and 93.3%, respectively for ureteral stones. Assessment of treatment effect classified by the location of stones revealed a stone-free rate of 94.6% and an efficacy rate of 94.6% for lower ureteral stones (4.0 mm or smaller, 1 subject; 4.1-10.0 mm, 31 subjects; 10.1-20.0 mm, 5 subjects: number of treatment sessions, 1 or 2 sessions [mean: 1.03 sessions]). Complications of this therapy included renal subcapsular hematoma and pyelonephritis in 1 case each.
Conclusions:
ESWL with the Sonolith vision manufactured by EDAP produced a treatment effect equivalent to those achieved with other models of ESWL equipment. ESWL seems to be an effective first-line treatment also in patients who have lower ureteral stones 10 mm or larger but do not wish to undergo TUL, if measures such as suitable positioning of the patient during treatment are taken.]]></description>
</item>

<item rdf:about="http://www.biomedcentral.com/1471-2490/11/25">
<title>Caveolin 1 protein expression in renal cell carcinoma predicts survival </title>
<link>http://www.biomedcentral.com/1471-2490/11/25</link>
<description><![CDATA[Background:
Caveolae play a significant role in disease phenotypes such as cancer, diabetes, bladder dysfunction, and muscular dystrophy. The aim of this study was to elucidate the caveolin-1 (CAV1) protein expression in renal cell cancer (RCC) and to determine its potential prognostic relevance.
Methods:
289 clear cell RCC tissue specimens were collected from patients undergoing surgery for renal tumors. Both cytoplasmic and membranous CAV1 expression were determined by immunohistochemistry and correlated with clinical variables. Survival analysis was carried out for 169 evaluable patients with a median follow up of 80.5 months (interquartile range (IQR), 24.5 - 131.7 months).
Results:
A high CAV1 expression in the tumor cell cytoplasm was significantly associated with male sex (p = 0.04), a positive nodal status (p = 0.04), and poor tumor differentiation (p = 0.04). In contrast, a higher than average (i.e. > median) CAV1 expression in tumor cell membranes was only linked to male sex (p = 0.03). Kaplan-Meier analysis disclosed significant differences in 5-year overall (51.4 vs. 75.2%, p = 0.001) and tumor specific survival (55.3 vs. 80.1%, p = 0.001) for patients with higher and lower than average cytoplasmic CAV1 expression levels, respectively. Applying multivariable Cox regression analysis a high CAV1 protein expression level in the tumor cell cytoplasm could be identified as an independent poor prognostic marker of both overall (p = 0.02) and tumor specific survival (p = 0.03) in clear cell RCC patients.
Conclusion:
Over expression of caveolin-1 in the tumour cell cytoplasm predicts a poor prognosis of patients with clear cell RCC. CAV1 is likely to be a useful prognostic marker and may play an important role in tumour progression. Therefore, our data encourage further investigations to enlighten the role of CAV1 and its function as diagnostic and prognostic marker in serum and/or urine of RCC patients.]]></description>
</item>

<item rdf:about="http://www.biomedcentral.com/1471-2490/11/24">
<title>Choroidal Metastases in Testicular Choriocarcinoma, successful treatment with chemo- and radiotherapy: a case report.
</title>
<link>http://www.biomedcentral.com/1471-2490/11/24</link>
<description><![CDATA[Background:
Choriocarcinoma is a very rare cause of ocular metastasis. Only 18 male patients have been reported on, 4 of whom survived, but with significant loss of vision.Case presentationA 26-year-old Caucasian man, suffering from testicular choriocarcinoma with pulmonary, cerebral, renal, hepatic and osseous metastases, underwent left radical orchiectomy. While being treated with chemotherapy, he presented with loss of vision in the left eye. Ophthalmoscopy revealed bilateral non-pigmented, hemorrhagic choroidal tumours, compatible with secondary lesions. Continued chemotherapy and stereotactic radiotherapy of the skull and spine lead to full remission with excellent vision, after more than 4 years of follow up.
Conclusion:
Testicular choriocarcinoma is an exceptional cause of choroidal metastasis, potentially asymptomatic and with specific clinical features. Radiotherapy can complement radical orchiectomy and chemotherapy, to achieve full remission and maintain good vision.]]></description>
</item>

<item rdf:about="http://www.biomedcentral.com/1471-2490/11/23">
<title>Predictors and outcome of surgical repair of obstetric fistula at a regional referral hospital, Mbarara, western Uganda</title>
<link>http://www.biomedcentral.com/1471-2490/11/23</link>
<description><![CDATA[Background:
Obstetric fistula although virtually eliminated in high income countries, still remains a prevalent and debilitating condition in many parts of the developing world. It occurs in areas where access to care at childbirth is limited, or of poor quality and where few hospitals offer the necessary corrective surgery.
Methods:
This was a prospective observational study where all women who attended Mbarara Regional Referral Hospital in western Uganda with obstetric fistula during the study period were assessed pre-operatively for social demographics, fistula characteristics, classification and outcomes after surgery. Assessment for fistula closure and stress incontinence after surgery was done using a dye test before discharge
Results:
Of the 77 women who were recruited in this study, 60 (77.9%) had successful closure of their fistulae. Unsuccessful fistula closure was significantly associated with large fistula size (Odds Ratio 6 95% Confidential interval 1.46-24.63), circumferential fistulae (Odds ratio 9.33 95% Confidential interval 2.23-39.12) and moderate to severe vaginal scarring (Odds ratio 12.24 95% Confidential interval 1.52-98.30). Vaginal scarring was the only factor independently associated with unsuccessful fistula repair (Odds ratio 10 95% confidential interval 1.12-100.57). Residual stress incontinence after successful fistula closure was associated with type IIb fistulae (Odds ratio 5.56 95% Confidential interval 1.34-23.02), circumferential fistulae (Odds ratio 10.5 95% Confidential interval 1.39-79.13) and previous unsuccessful fistula repair (Odds ratio 4.8 95% Confidential interval 1.27-18.11). Independent predictors for residual stress incontinence after successful fistula closure were urethral involvement (Odds Ratio 4.024 95% Confidential interval 2.77-5.83) and previous unsuccessful fistula repair (Odds ratio 38.69 95% Confidential interval 2.13-703.88).
Conclusions:
This study demonstrated that large fistula size, circumferential fistulae and marked vaginal scarring are predictors for unsuccessful fistula repair while predictors for residual stress incontinence after successful fistula closure were urethral involvement, circumferential fistulae and previous unsuccessful fistula repair.]]></description>
</item>

<item rdf:about="http://www.biomedcentral.com/1471-2490/11/22">
<title>ROS generation via NOX4 and its utility in the cytological diagnosis of urothelial carcinoma of the urinary bladder</title>
<link>http://www.biomedcentral.com/1471-2490/11/22</link>
<description><![CDATA[Background:
Reactive oxygen species (ROS) production via NADPH oxidase (NOX) contributes to various types of cancer progression. In the present research, we examined the pathobiological role of NADPH oxidase (NOX)4-mediated generation of reactive oxygen species (ROS) in urothelial carcinoma (UC) of the urinary bladder, and demonstrated the utility of ROS labeling in urine cytology.
Methods:
NOX4 gene was silenced in vivo and in vitro by NOX4 siRNA transfection with or without atlocollagen. Cell cycle and measurement of ROS were analyzed by flowcytometry. Orthotopic implantation animal model was used in vivo experiment. NOX4 expression in urothelial carcinoma cells was observed by immunohistochemical analysis using surgical specimens of human bladder cancer. Urine cytology was performed after treatment with ROS detection reagents in addition to Papanicolaou staining.
Results:
NOX4 was overexpressed in several UC cell lines and the NOX inhibitor, diphenylene iodonium reduced intracellular ROS and induced p16-dependent cell cycle arrest at the G1 phase. Moreover, silencing of NOX4 by siRNA significantly reduced cancer cell growth in vivo as assessed in an orthotopic mouse model. Immunohistochemistry demonstrated high expression of NOX4 in low grade/non-invasive and high grade/invasive UC including precancerous lesions such as dysplasia but not in normal urothelium. Then, we assessed the usefulness of cytological analysis of ROS producing cells in urine (ROS-C). Urine samples obtained from UC cases and normal controls were treated with fluorescent reagents labeling the hydrogen peroxide/superoxide anion and cytological atypia of ROS positive cells were analyzed. As a result, the sensitivity for detection of low grade, non-invasive UC was greatly increased (35% in conventional cytology (C-C) vs. 75% in ROS-C), and the specificity was 95%. Through ROS-C, we observed robust improvement in the accuracy of follow-up urine cytology for cases with previously diagnosed UC, especially in those with low grade/non-invasive cancer recurrence (0% in C-C vs. 64% in ROS-C).
Conclusions:
This is the first report demonstrating that ROS generation through NOX4 contributes to an early step of urothelial carcinogenesis and cancer cell survival. In addition, cytology using ROS labeling could be a useful diagnostic tool in human bladder cancer.]]></description>
</item>

<item rdf:about="http://www.biomedcentral.com/1471-2490/11/21">
<title>Overall and worst Gleason scores are equally good predictors of prostate cancer progression </title>
<link>http://www.biomedcentral.com/1471-2490/11/21</link>
<description><![CDATA[Background:
Gleason scoring has experienced several modifications during the past decade. So far, only one study has compared the prognostic abilities of worst (WGS) and overall (OGS) modified Gleason scores after the ISUP 2005 conference. Prostatic needle biopsies are individually paraffin-embedded in 57% of European pathology laboratories, whereas the rest of laboratories embed multiple (2 - 6) biopsies per one paraffin-block. Differences in the processing method can have a far-reaching effect, because reporting of the Gleason score (GS) is different for individually embedded and pooled biopsies, and GS is one of the most important factors when selecting treatment for patients.
Methods:
The study material consisted of needle biopsies from 236 prostate cancer patients that were endocrine-treated in 1999-2003. Biopsies from left side and right side were embedded separately. Haematoxylin-eosin-stained slides were scanned and analyzed on web-based virtual microscopy. Worst and overall Gleason scores were assessed according to the modified Gleason score schema after analyzing each biopsy separately. The compound Gleason scores (CGS) were obtained from the original pathology reports. Two different grade groupings were used: GS 6 or less vs. 7 vs. 8 or above; and GS 7(3 + 4) or less vs. 7(4 + 3) and 8 vs. 9-10. The prognostic ability of the three scoring methods to predict biochemical progression was compared with Kaplan-Meier survival analysis and univariate and multivariate Cox regression analyses.
Results:
The median follow-up time of the patients was 64.5 months (range 0-118). The modified GS criteria led to upgrading of the Gleason sums compared to the original CGS from the pathology reports 1999-2003 (mean 7.0 for CGS, 7.5 for OGS, 7.6 for WGS). In 43 cases WGS was > OGS. In a univariate analysis the relative risks were 2.1 (95%-confidence interval 1.8-2.4) for CGS, 2.5 (2.1-2.8) for OGS, and 2.6 (2.2-2.9) for WGS. In a multivariate analysis, OGS was the only independent prognostic factor.
Conclusions:
All of the three Gleason scoring methods are strong predictors of biochemical recurrence. The use of modified Gleason scoring leads to upgrading of GS, but also improves the prognostic value of the scoring. No significant prognostic differences between OGS and WGS could be shown, which may relate to the apparent narrowing of the GS scale from 2-10 to 5-10 due to the recent modifications.]]></description>
</item>

<item rdf:about="http://www.biomedcentral.com/1471-2490/11/20">
<title>A case of squamous cell carcinoma arising from a suprapubic cystostomy tract</title>
<link>http://www.biomedcentral.com/1471-2490/11/20</link>
<description><![CDATA[Background:
Patients with spinal cord injury and a chronic indwelling urinary catheter are known to have an increased risk of bladder malignancy. However, squamous cell carcinoma (SCC) of the epidermis around a suprapubic cystostomy is relatively rare. Here, we report a case of lower abdominal SCC arising from the suprapubic cystostomy tract.Case presentationA 58-year-old man with a complete spinal cord injury was referred to our hospital with a chief complaint of an abdominal mass. Abdominal enhanced computed tomography (CT) showed a 7-cm mass surrounding the suprapubic cystostomy and bilateral inguinal and para-aortic lymph nodes metastasis. Histopathological examination of percutaneous biopsy specimens was performed. The diagnosis was stage IV (cT4N1M1) epidermal SCC, which was treated with palliative external radiation therapy.
Conclusion:
The SCC in this case was thought to arise from mechanical stimulus of the suprapubic cystostomy. Physicians and patients should pay careful attention to any signs of neoplasms with long-term indwelling catheters, such as skin changes around the suprapubic cystostomy site. This case presentation is only the fourth report of SCC arising from the suprapubic cystostomy tract in the literature. In cases of unresectable tumors and contraindications to chemotherapy, palliative radiotherapy may lead to disease remission and symptom relief.]]></description>
</item>

<item rdf:about="http://www.biomedcentral.com/1471-2490/11/19">
<title>Phosphatidylinositol 3&#x27;-kinase, mTOR, and Glycogen synthase kinase-3 beta mediated regulation of p21 in human urothelial carcinoma cells</title>
<link>http://www.biomedcentral.com/1471-2490/11/19</link>
<description><![CDATA[Background:
The PTEN/Phosphatidylinositol 3'-kinase (PI3-kinase) growth factor signaling pathway plays a critical role in epithelial tumor development in a multitude of tissue types. Deletion of the Pten tumor suppressor gene in murine urothelial cells in vivo results in upregulation of cyclin-dependent kinase inhibitor p21. We have previously shown in mice that p21 expression blocks an increase in urothelial cell proliferation due to Pten deletion. In this study, we utilized human urothelial carcinoma cells UMUC-3 and UMUC-14 to identify the signaling pathways downstream of PI3-kinase that regulate p21.
Methods:
Cells were treated with a combination of PI3-kinase stimulating growth factors and kinase inhibitors, or transfected with exogenous genes in order to identify the signaling events that are necessary for p21 induction. Mice with conditional deletion of Pten in bladder urothelium were also examined for evidence of PI3-kinase pathway signaling events that affect p21 expression.
Results:
When cells were treated with PI3-kinase activating growth factors EGF or PDGF, we found that p21 levels increased, in a manner similar to that observed in mice. We used the inhibitors LY294002, Akti-1/2, and rapamycin, to show that p21 induction is dependent upon PI3-kinase and AKT activity, and partially dependent on mTOR. We treated the cells with proteasome inhibitor MG-132 and found that p21 may be degraded in the proteasome to regulate protein levels. Importantly, our findings show that GSK-3β plays a role in diminishing p21 levels in cells. Treatment of cells with the GSK-3β inhibitor SB-216763 increased p21 levels, while exogenous expression of GSK-3β caused a decrease in p21, indicating that GSK-3β actively reduces p21 levels. We found that a combined treatment of LY294002 and SB-216763 improved the cytotoxic effect against UMUC-3 and UMUC-14 carcinoma cells over LY294002 alone, suggesting potential therapeutic uses for GSK-3β inhibitors. Immunohistochemical staining in bladders from wild-type and Pten-deleted mice indicated that GSK-3β inhibitory phosphorylation increases when Pten is deleted.
Conclusion:
PI3-kinase and AKT cause an upregulation of p21 by suppressing GSK-3β activity and activating mTOR in both cultured human urothelial carcinoma cells and mouse urothelial cells in vivo.]]></description>
</item>

</rdf:RDF>
