Transplant RSS : Gourt

Some doctors tout NanoKnife for tumor removal - Seattle Times

Some doctors tout NanoKnife for tumor removalSeattle Times"Rather than using surgery or a transplant, we decided to try this noninvasive technique," said Narayanan. "We did a scan afterwards and it looked very good ...and more »

Hand transplant recipient improves, is released from hospital - Pittsburgh Tribune-Review

Hand transplant recipient improves, is released from hospitalPittsburgh Tribune-ReviewThe surgery is part of a recent program at UPMC that aims to reduce the amount of anti-rejection drugs patients take after the transplant.and more »

British doctors pioneer 'incompatible' kidney transplant surgery - The Hindu

BBC NewsBritish doctors pioneer 'incompatible' kidney transplant surgeryThe HinduPTI In a ground-breaking operation, British surgeons claim to have transplanted an “incompatible” donor kidney on a female patient, after freezing and ...Incompatible kidney surgery a world firstNEWS.com.auall 36 news articles »

Nerve Graft Transplant Can Prove Successful in Eliminating Many Life ... - SYS-CON Media (press release)

Nerve Graft Transplant Can Prove Successful in Eliminating Many Life ...SYS-CON Media (press release)The Plastic Surgery Center today announced that an innovative nerve graft transplant performed by Dr. Andrew Elkwood has proven to be successful in treating ...and more »

Histostem Participates in Successful Stem Cell Treatment for Acute Spinal Cord ... - CNNMoney.com (press release)

Histostem Participates in Successful Stem Cell Treatment for Acute Spinal Cord ...CNNMoney.com (press release)In addition to this breakthrough in the technique used to transplant stem cells, we also had success in improving the condition of the spinal cord injury ...and more »

'House': Cuddy takes center stage - Zap2it.com (blog)

Zap2it.com (blog)'House': Cuddy takes center stageZap2it.com (blog)House rubs it in by insisting that Chase perform the patient's liver transplant to emphasize the fact that he's got the best surgeon. ...and more »

Moorhead woman receives double lung transplant - In-Forum

Moorhead woman receives double lung transplantIn-ForumThe eight-hour wait during the surgery was both exhilarating and harrowing, Bruce said. “You're happy it's happening because it will give her life,” he said ...

Transplant a gift of life - Stuff.co.nz

Stuff.co.nzTransplant a gift of lifeStuff.co.nzThe family moved to Omaha two months ago to wait for Aria's surgery. ANOTHER CHANCE: A gift of organs from an unknown child has given Aria MacDonald her ...and more »

Todd Brown's Gift of Life - WAAY

Todd Brown's Gift of LifeWAAYMr. James Caldwell, assistant dean in Holland Hall, and faculty member Dr. James Doggette, are both recuperating after successful transplant surgery. ...and more »

Medical Malpractice Lawsuit News: Brothers sue for transplant complications - NewYorkInjuryNews

Medical Malpractice Lawsuit News: Brothers sue for transplant complicationsNewYorkInjuryNewsBoth of the men suffered from complications from the surgery of the live transplant. The two brothers identified as California resident 45-year-old Peter ...

0041-1345; +252 new citations

252 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: 0041-1345 These pubmed results were generated on 2010/01/12PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources.

Benefit of immune monitoring in heart transplant patients using ATP production in activated lymphocytes.

Benefit of immune monitoring in heart transplant patients using ATP production in activated lymphocytes. J Heart Lung Transplant. 2010 Feb 3; Authors: Kobashigawa JA, Kiyosaki KK, Patel JK, Kittleson MM, Kubak BM, Davis SN, Kawano MA, Ardehali AA BACKGROUND: Balancing immunosuppression to prevent rejection while minimizing infection or drug toxicity risk is a major challenge in heart transplantation. Therapeutic drug monitoring alone is inadequate to measure the immune response. An immune monitoring (IM) assay (ImmuKnow; Cylex, Columbia, MD) performed on peripheral blood measures adenosine triphosphatase (ATP) release from activated lymphocytes and may predict the immune state. Therefore, we sought to determine the utility of IM in heart transplant recipients. METHODS: Between November 2005 and July 2008, 296 heart transplant recipients had a total of 864 IM assays performed at 2 weeks to 10 years post-transplant and were correlated with infection and rejection events that occurred within 1 month after IM testing. All patients received standard triple-drug immunosuppressive therapy with tacrolimus, mycophenolate mofetil and corticosteroids, without induction therapy. RESULTS: There were 38 infectious episodes and 8 rejection episodes. The average IM score was significantly lower during infection than steady state (187 vs 280 ng ATP/ml, p < 0.001). The average IM score was not significantly different during rejection when compared with steady state (327 vs 280 ng ATP/ml, p = 0.35). Interestingly, 3 of 8 rejection episodes were antibody-mediated rejections and had hemodynamic compromise and, for these, the mean IM score was significantly higher than for steady-state patients (491 vs 280 ng ATP/ml, p < 0.001). CONCLUSIONS: The non-invasive IM test appears to predict infectious risk in heart transplant patients. The association between high IM scores and rejection risk is inconclusive due to the small number of rejection episodes. Further studies with larger sample sizes for rejection episodes are required. PMID: 20133166 [PubMed - as supplied by publisher]

Paracorporeal biventricular mechanical circulatory support for more than 4 years.

Paracorporeal biventricular mechanical circulatory support for more than 4 years. J Heart Lung Transplant. 2010 Feb 2; Authors: Drews T, Krabatsch T, Huebler M, Hetzer R We present a patient who was evaluated for heart transplantation, but because of acute cardiac decompensation with cardiopulmonary resuscitation and multiorgan failure, had the indication for biventricular mechanical circulatory support. The patient was maintained on mechanical circulatory support for more than 4 years until he became eligible to receive a heart allograft. PMID: 20133165 [PubMed - as supplied by publisher]

Optimization of axial-pump pressure sensitivity for a continuous-flow total artificial heart.

Optimization of axial-pump pressure sensitivity for a continuous-flow total artificial heart. J Heart Lung Transplant. 2010 Feb 3; Authors: Frazier OH, Khalil HA, Benkowski RJ, Cohn WE BACKGROUND: In this study, we describe the potential advantages of a continuous-flow total artificial heart (CFTAH) comprising two small, non-pulsatile pumps with optimized responsiveness to the pressure gradient. METHODS: We modified a MicroMed DeBakey axial-flow pump by increasing its inducer-impeller inlet angle, thereby increasing its pressure responsivity. We obtained the in vitro pressure gradient response and compared it with those of the clinically used, unmodified MicroMed DeBakey pump, Jarvik 2000 FlowMaker and HeartMate II. RESULTS: The modified pump showed an increased response to changes in the pressure gradient at pump flow rates of between 2 and 4 liters/min. The maximum pressure responsivity of the modified pump was 2.5 liters/min/mm Hg; the corresponding maximum responsivities of the Jarvik 2000, HeartMate II and MicroMed DeBakey ventricular assist devices (VADs) were 0.12, 0.09 and 0.38 liters/min/mm Hg, respectively. CONCLUSIONS: Because of the inherent properties of non-pulsatile pumps, the CFTAH may potentially respond to changes in inflow and outflow pressures while maintaining physiologic flow rates sufficient for normal daily activity. In addition, the hemodynamic interplay between the two optimized pumps should allow a physiologic response to normal flow imbalances between the pulmonary and systemic circulations. Improved responsiveness to inflow pressure may further simplify and improve the CFTAH and affect its potential clinical use as a meaningful therapy for terminal heart failure. PMID: 20133164 [PubMed - as supplied by publisher]

Azithromycin is associated with increased survival in lung transplant recipients with bronchiolitis obliterans syndrome.

Azithromycin is associated with increased survival in lung transplant recipients with bronchiolitis obliterans syndrome. J Heart Lung Transplant. 2010 Feb 2; Authors: Jain R, Hachem RR, Morrell MR, Trulock EP, Chakinala MM, Yusen RD, Huang HJ, Mohanakumar T, Patterson GA, Walter MJ BACKGROUND: Previous studies have suggested that azithromycin improves lung function in lung transplant recipients with bronchiolitis obliterans syndrome (BOS). However, these studies did not include a non-treated BOS control cohort or perform survival analysis. This study was undertaken to estimate the effect of azithromycin treatment on survival in lung transplant recipients with BOS. METHODS: We conducted a retrospective cohort study of consecutive lung transplant recipients who developed BOS between 1999 and 2007. An association between azithromycin treatment and death was assessed using univariate and multivariate time-dependent Cox regression analysis. RESULTS: Of the 178 recipients who developed BOS in our study, 78 did so after 2003 and were treated with azithromycin. The azithromycin-treated and untreated cohorts had similar baseline characteristics. Univariate analysis demonstrated that azithromycin treatment was associated with a survival advantage and this beneficial treatment effect was more pronounced when treatment was initiated during BOS Stage 1. Multivariate analysis demonstrated azithromycin treatment during BOS Stage 1 (adjusted hazard ratio = 0.23, p = 0.01) and absolute forced expiratory volume in 1 second (FEV(1)) at the time of BOS Stage 1 (adjusted hazard ratio = 0.52, p = 0.003) were both associated with a decreased risk of death. CONCLUSIONS: In lung transplant recipients with BOS Stage 1, azithromycin treatment initiated before BOS Stage 2 was independently associated with a significant reduction in the risk of death. This finding supports the need for a randomized, controlled trial to confirm the impact of azithromycin on survival in lung transplant recipients. PMID: 20133163 [PubMed - as supplied by publisher]

Waiting List: A Doctor and His Patient Wait for a Heart.

Waiting List: A Doctor and His Patient Wait for a Heart. J Heart Lung Transplant. 2010 Feb 2; Authors: Colombo PC, Segal RD PMID: 20133162 [PubMed - as supplied by publisher]

A retrospective study of silicone stent placement for management of anastomotic airway complications in lung transplant recipients: short- and long-term outcomes.

A retrospective study of silicone stent placement for management of anastomotic airway complications in lung transplant recipients: short- and long-term outcomes. J Heart Lung Transplant. 2010 Feb 3; Authors: Dutau H, Cavailles A, Sakr L, Badier M, Gaubert JY, Boniface S, Doddoli C, Thomas P, Reynaud-Gaubert M BACKGROUND: Airway anastomotic complications remain a major cause of morbidity and mortality after lung transplantation (LT). Few data are available with regard to the use of silicone stents for these airway disorders. The aim of this retrospective study was to evaluate the clinical efficacy and safety of silicone stents for such an indication. METHODS: Data of adult lung transplant recipients who had procedures performed between January 1997 and December 2007 at our institution were reviewed retrospectively. We included patients with post-transplant airway complications who required bronchoscopic intervention with a silicone stent. RESULTS: In 17 of 117 (14.5%) LT recipients, silicone stents were inserted at a mean time of 165 (range 5 to 360) days after surgery in order to palliate 23 anastomotic airway stenoses. Symptomatic improvement was noted in all patients, and mean forced expiratory volume in 1 second (FEV(1)) increased by 672 +/- 496 ml (p < 0.001) after stent insertion. The stent-related complication rate was 0.13/patient per month. The latter consisted of obstructive granulomas (n = 10), mucus plugging (n = 7) and migration (n = 7), which were of mild to moderate severity and were successfully managed endoscopically. Mean stent duration was 266 days (range 24 to 1,407 days). Successful stent removal was achieved in 16 of 23 cases (69.5%) without recurrence of stenosis. Overall survival was similar in patients with and without airway complications (p = 0.36). CONCLUSIONS: Silicone stents allow clinical and lung function improvement in patients with LT-related airway complications. Stent-related complications were of mild to moderate severity, and were appropriately managed endoscopically. Permanent resolution of airway stenosis was obtained in most patients, allowing definitive stent removal without recurrence. PMID: 20133161 [PubMed - as supplied by publisher]

Exercise training after lung transplantation: A systematic review.

Exercise training after lung transplantation: A systematic review. J Heart Lung Transplant. 2010 Feb 2; Authors: Wickerson L, Mathur S, Brooks D BACKGROUND: Lung transplant recipients experience persistent impairments in exercise capacity and skeletal muscle function despite a vast improvement in lung function after transplantation. Exercise training may be beneficial in improving exercise capacity in lung transplant recipients. A systematic review was undertaken to examine the evidence for exercise training on functional outcomes in lung transplant recipients. METHODS: Studies were identified by searching electronic databases and scanning reference lists. Only randomized controlled trials, controlled trials, and prospective cohorts were included in the review. Seven studies met the inclusion criteria. Study quality was assessed using the Physiotherapy Evidence Database, Jadad, and Downs scales. RESULTS: The overall quality of studies was fair to moderate in assessing the effect of exercise training on maximal and functional exercise capacity, skeletal muscle function, and lumbar bone mineral density. Every study reported significant improvements in these outcomes. Some studies lacked randomization and/or a control group, so it was not possible to separate the effects of training with the natural recovery process after lung transplantation. CONCLUSION: Some evidence was found to support that a period of structured exercise training could improve maximal and functional exercise capacity, skeletal muscle strength, and lumbar bone mineral density in lung transplant recipients. Further studies are needed to determine the potential for exercise training to optimize these functional outcomes and to develop optimal guidelines for exercise prescription in the lung transplant population. PMID: 20133160 [PubMed - as supplied by publisher]