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A hysterectomy is the surgical removal of the uterus, usually done by a gynecologist. Hysterectomy may be total (removing the body and cervix of the uterus) or partial (also called supra-cervical). In many cases, surgical removal of the ovaries (oophorectomy) is performed concurrent with a hysterectomy. The surgery is then called "total abdominal hysterectomy with bilateral salpingo-oophorectomy."

Women who have total abdominal hysterectomy with bilateral salpingo-oophorectomy surgeries lose most of their ability to produce the female hormones estrogen and progesterone and subsequently enter what is known as "surgically-induced menopause" (as opposed to normal menopause, which occurs naturally in women as part of the aging process). In women under the age of 50, hormone supplements (usually estrogen) are often prescribed as part of hormone replacement therapy (HRT) to offset the negative effects of sudden hormonal loss (most notably an increased risk for early-onset osteoporosis). This treatment is somewhat controversial due to the known carcinogenic and coagulative properties of estrogen; however, many physicians and patients feel the benefits outweigh the risks in women who would otherwise be "too young" to be in full-blown menopause.

Although many hysterectomies are performed via a full abdominal incision laparotomy, two common surgical approaches which are less invasive are laparoscopically or vaginally. Surgery with ovarian conservation is an option for the pre-menopausal patient with benign disease (non cancer).

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