Gourt > Health > Medicine > Medical Specialties > Hematology > Bone Marrow Transplantation
Bone marrow transplantation (BMT) or hematopoietic stem cell transplantation (HSCT) is a medical procedure in the field of hematology and oncology that involves transplantation of hematopoietic stem cells (HSC). It is most often performed for people with diseases of the blood or bone marrow, or certain types of cancer. Bone marrow transplantation was pioneered in the 1970's by E. Donnall Thomas whose work was later recognized with a Nobel Prize in Physiology and Medicine. Dr. Thomas' work showed that bone marrow cells infused intravenously could repopulate the bone marrow and produce new blood cells. His work also reduced the likelihood of developing a life-threatening complication called Graft-versus-host disease (GVHD). However it remains a risky procedure and it is reserved for patients with life threatening diseases.
Principles
Most recipients of HSCTs are leukemia patients or others who would benefit from treatment with high doses of chemotherapy or Total body irradiation (TBI). Other patients who receive bone marrow transplants include pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or congenital neutropenia and was born with defective stem cells. Children or adults with aplastic anemia have lost their stem cells after birth and may not require such high doses of chemotherapy and irradiation prior to a transplant. In this case there is a greater need for immunosuppressive agents. Other conditions that bone marrow transplants are considered for include thalassemia major, sickle-cell disease, myelodysplastic syndrome, lymphoma, and multiple myeloma. More recently non-myeloablative, or so-called "mini transplant" procedures have been developed which do not require such large doses of chemotherapy and radiation. This has allowed HSCT to be conducted in older patients and without the need for hospitalization.
Stem cell collection
Types of donors
There are two major types of bone marrow transplantation. Autologous bone marrow transplantation involves isolation of HSC from a patient, storage of the stem cells in a freezer, medical treatment of the patient that destroys stem cells remaining in the body, and return of the patient's own stored stem cells to their body. Autologous transplants have the advantage of a lower risk of graft rejection, infection and GVHD. Allogeneic bone marrow transplantation involves two people, one is the (normal) donor and one is the (patient) recipient. Allogeneic HSC donors must have a tissue (HLA) type that matches the recipient and, in addition, the recipient requires immunosuppressive medications. Allogeneic transplant donors may be related (usually a sibling) or unrelated volunteers. More on [ Bone marrow transplant ]
Blood Disorders : Anemia
Hematologic :: Cancer
Transplantation Education
Marrow and Cord Blood Registries
Cell Transplantation And Cardiac Repair - Science Daily (press release)
Wed, 01 Jul 2009 19:22:43 -0000
Cell Transplantation And Cardiac RepairScience Daily (press release)Bone marrow cell transplantation has been shown to induce new blood vessel growth (angiogenesis) and foster improvements in patients with ischemic artery ...and more »
Embryonic Stem Cells—and Other Stem Cells—Promise to Advance ... - U.S. News & World Report
Thu, 02 Jul 2009 16:07:46 -0000
ReutersEmbryonic Stem Cells—and Other Stem Cells—Promise to Advance ...U.S. News & World ReportAdult stem cells have been used in bone marrow transplants for 40 years, and trials like the one involving Clegg are expected to expand their use. ...Policy Shift On Stem Cell Research May Produce Effect OverseasLife Science Leader MagazineREGENERATIVE MEDICINEpharmabiz.comall 130 news articles »
Save a life at Blood Drive, Bone Marrow Search set for July 18 - Cape Coral Daily Breeze
Thu, 02 Jul 2009 04:20:22 -0000
Save a life at Blood Drive, Bone Marrow Search set for July 18Cape Coral Daily Breeze"One bone marrow transplant could save Kenny's life," he said. Kenny is one of the more than 10000 people each year with a life-threatening disease who ...and more »
Davis Man's Search for Lifesaving Blood Marrow Donor - News10.net
Thu, 02 Jul 2009 00:57:15 -0000
Davis Man's Search for Lifesaving Blood Marrow DonorNews10.netGee said two experimental drug trials failed, and his doctors say his final treatment option is a bone marrow transplant. Gee's brother isn't a match, ...and more »
Bone marrow donor drive today to honor Highland Village father - Dallas Morning News
Sat, 27 Jun 2009 07:36:57 -0000
Dallas Morning NewsBone marrow donor drive today to honor Highland Village fatherDallas Morning NewsDoug Campbell is awaiting a bone marrow transplant with his family (clockwise from top left), daughters Meghan and Cassandra, wife Stacey and daughter Keely ...and more »
Rihanna on Jasmina Anema's bone marrow transplant: 'Miracles do ... - New York Daily News
Fri, 12 Jun 2009 20:27:36 -0000
Ear SuckerRihanna on Jasmina Anema's bone marrow transplant: 'Miracles do ...New York Daily NewsRihanna said Friday that the brave girls's bone marrow transplant was proof that 'miracles do happen.' A day after cancer-stricken Jasmina Anema received a ...Six-Year-Old Rihanna Fan Receives Bone Marrow TransplantMyStateline.comNYC girl undergoes marrow transplatNewsdaySix-Year-Old Harlem Girl Gets Bone Marrow TransplantNY1Access Hollywood -Examiner.com -New York Daily Newsall 27 news articles »
Blood and Marrow Transplant Information Network - A not-for-profit organization that provides publications and support services to bone marrow, peripheral blood stem cell, and cord blood transplant patients and survivors.
Blood and Marrow Transplant Surgery - Medical Information Guide - Health guide presented by University of Maryland Medicine covering this treatment for cancer. Guide includes definition, treatable conditions such as breast cancer and resources available that perform the surgery.
BMTnet - Information on Bone Marrow Transplant includes a directory of personnel involved and directory of transplant centers.
BMTresources.org - Online resource dedicated to blood and bone marrow transplantation.
Meta Description: [ bone marrow transplant, stem cell transplant, stem cell research ]
Bone Marrow Donors Worldwide - A project for the collection of the HLA phenotypes of volunteer bone marrow donors and cord blood units, and for the coordination of their worldwide distribution.
Meta Description: [ BMDW is a project for the collection of the HLA phenotypes of volunteer bone marrow donors and cord blood units, and for the coordination of their worldwide distribution. ]
Bone Marrow Transplant - Web resource from UCSF Medical Center. Provides information regarding blood and bone marrow transplants to treat a number of blood disorders and cancer.
Bone Marrow Transplant for solid tumor study program - Program from the University of Texas M.D Anderson's Center. Articles, appointments and links.
Bone Marrow Transplant Specialists - Biligual English/Spanish website from a Bone Marrow transplant program. A lot of original information on BM transplantation and diseases.
Meta Description: [ Especialistas en Trasplante de Medula Osea , Monterrey , mexico , Bone Marrow Transplant Specialists ]
British Society of Blood and Marrow Transplantation - An organisation for those with a professional interest in stem cell transplantation, in clinical collaboration and the development of clinical trials in this field.
City of Hope Bone Marrow Transplant - About their BMT services, history and upcoming programmes.
Meta Description: [ The largest provider of bone marrow transplant services in California, performing more than 400 bone marrow transplantation procedures annually. ]
Czech National Marrow Donors Registry - Czech organization provides recruitment, examination and registration of donors for bone marrow transplants to patients with leukemia, cancer and other life-threatening diseases.
Meta Description: [ Czech National Marrow Donors Registry (CNMDR) provides recruitment, HLA examination and registration of volunteer marrow donors for bone marrow transplants to patients with leukemia, cancer and other life-threatening diseases all over the world. Supported by Bone Marrow Transplant Foundation. ]
European Group for Blood and Marrow Transplatation - Provides both EBMT members and other physicians involved in bone marrow transplant with information on related meetings, registries and data management, transplant guidelines, accreditation and corporate sponsorship. Based in Nijmegen, The Netherlands.
Meta Description: [ European Group for Blood and Marrow Transplantation. This site provides both EBMT members and other physcians involved in BMT with information on related meetings, registries and data mangement, Working Parties, transplant guidelines, accreditation and corporate sponsorship. Members have access ... ]
Fairview-University Blood and Marrow Transplant Services - University of Minnesota physicians develop new blood and marrow transplant (bone marrow transplant)(bmt) treatments for metabolic disorders, anemias and bone and soft tissue cancers(myelomas, lymphomas, sarcomas).
Meta Description: [ Fairview-University Blood and Marrow Transplant Services, affiliated with the University of Minnesota, has been at the forefront of blood and marrow transplant (BMT) advances since performing the world’s first BMT in 1968. ]
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Genelex - Provides service of lineage specific DNA chimerism for tracking hematopoietic stem cell engraftment.
International Bone Marrow Transplant Registry - Organization of basic and clinical scientists researching important issues in blood and marrow transplantation. IBMTR is not a donor registry.
Meta Description: [ The Center for International Blood and Marrow Transplant Research (CIBMTR) unites and builds on the strengths of two leaders in the field of blood and marrow transplantation, the International Bone Marrow Transplant Registry and the Autologous Blood and Marrow Transplant Registry (IBMTR/ABMTR) an... ]
M. D. Anderson Cancer Center - Blood and Marrow Transplantation - Current research and treatments involving blood and marrow transplantation including studies of stem cell and cord blood transplants.
Meta Description: [ The Blood and Marrow Transplantation Center is a multidisciplinary setting for consultation, evaluation, treatment planning, and management of hematologic malignancies and solid tumors. ]
Marrow Transplants Offer Hope for Incurable Disorders - Review article from Medical College of Wisconsin about therapeutic potential of bone marrow transplantation.
Meta Description: [ Bone marrow transplantation was introduced in 1968, giving patients with cancers and other serious diseases a new chance at life. Today, the Medical College is one of the leading centers worldwide for research in this field. ]
Mayo Clinic: Bone Marrow Transplantation - Offers pediatric blood and bone marrow transplant services for children and adolescents. Provide information about available treatments, transplantation process, and hospital locations.
National Marrow Donor Program - Provides marrow transplants from volunteer unrelated donors to patients with leukemia, aplastic anemia and other potentially life-threatening blood diseases.
Meta Description: [ Information and resources for donors, patients and physicians about bone marrow and cord blood transplants and the latest news about the National Marrow Donor Program. ]
National Marrow Donor Program Research - NMDP research program focuses on improving clinical outcomes of blood stem cell transplantation. Provides information regarding research policies, grants, and studies in progress.
Meta Description: [ The focus of the NMDP Research Program is on improving clinical outcomes and increasing the indications for unrelated stem cell transplant. ]
South Florida Bone Marrow and Stem Cell Transplant Institute - Mission statement, procedures, schedules and location information for this center in Boynton Beach, Florida.
Meta Description: [ Bone marrow stem cell transplant for myeloma, hodgkins, leukemia, more. We do bone marrow stem cell transplant for myeloma and hodgkins. For myeloma and hodgkins, get bone marrow stem cell transplant., Bone marrow stem cell transplant for myeloma, hodgkins, leukemia, more. We do bone marrow stem ... ]
St Petersburg Center of Haematology - St. Petersburg Russia State Medical University's marrow donor database, AdVita foundation, fund-raising efforts. Also has a patient education section.
Meta Description: [ Donations for bone marrow transplant of the patients of Center of Haematlogy.@ ]
Stem Cell Transplants - Resources for hematopoietic stem cell transplantation, particularly focusing on advances in nonmyeloablative conditioning regimens.
Meta Description: [ We are a resource to assist patients and families in learning about the options available for stem cell transplantation. ]
Umbilical Cord Blood Provides New Hope for Leukemia Patients - Review article about transplantation of cord blood.
Meta Description: [ Transplantation of cord blood - normally discarded after a baby's birth - provides leukemia patients with stem cells, enabling them to produce healthy blood cells in a procedure shown to be highly effective in children with the disease.
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UMCC Bone Marrow Transplant Service - Special inpatient and outpatient clinics devoted to both adult and pediatric bone marrow transplantation.
Meta Description: [ The University of Michigan Comprehensive Cancer Center has special inpatient and outpatient clinics devoted to bone marrow transplantation with a number of medical experts who collaborate on the care of each patient. ]
World Marrow Donor Association - Promotes the exchange of information and development of standards to facilitate the exchange of hematopoietic stem cells (HSC) across international borders.
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