Mucous membrane pemphigoid is an autoimmune reaction that occurs at the level of the basement membrane. Commonly affects gingiva. Desquamating/blistering disease in which epithelial separation takes place at the level of the basement membrane.

Antibodies (IgG) precipitates complement (C3) in the lamina lucida of the BM. Circulating auto-antibodies to BP-1 antigen (located in hemidesmosome). 50% have BP-2. Positive Nikolsky sign. IgG, C3 deposition at BM creating smooth line in immunoflourescent analysis.

See also

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• Bullous pemphigoid

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Diagnosed a blistering skin disease today that occurs rarely in association with pregnancy (pemphigoid gestationis شبيه الفقاع الحملي )
sate3 (Sate Hamza ساطع ) Wed, 28 Oct 2009 23:27:38 -0000
Diagnosed a blistering skin disease today that occurs rarely in association with pregnancy (pemphigoid gestationis شبيه الفقاع الحملي )

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