Gourt > Health > Conditions and Diseases > Nutrition and Metabolism Disorders > Vitamins and Minerals > Wilson's Disease
Wilson's disease or hepatolenticular degeneration is an autosomal recessive hereditary disease, with an incidence of about 1 in 30,000 in most parts of the world and a male preponderance (although incidences up to 1:200 have been reported in Central America, especially in El Salvador). Its main feature is accumulation of copper in tissues, which manifests itself with neurological symptoms and liver disease. The estimated heterozygous carrier rate is about 1 in 9,000, meaning that 1 in 9,000 people are unaffected carriers of this mutation.
Signs and symptoms
Symptoms usually appear around the ages of 18 to 21 years, but sometimes not until the age of 30, and in rare instances up to age 50. Presentation before 5 years of age is extremely rare, despite the biochemical defect being present at birth.
The age of presentation seems to correlate with the organ system involved. About half (40–50%) of patients first present with hepatic symptoms and half (40–50%) with neurologic symptoms. The average age for hepatic symptoms is 10–14 years, compared with 19–22 years for neurologic symptoms. Patients rarely present after age 40.
More on [ Wilson's disease ]
Liver :: Digestive Disorders
Genetic Disorders
Brain Diseases
Rare Disorders :: Conditions and Diseases
EuroWilson - Contains information about Wilson disease of interest to patients, family members and health care professionals.
Meta Description: [ The EuroWilson website contains information about Wilson disease that we believe might be of interest to patients, family members and health care professionals. We strive to ensure that the contents are correct and up-to-date. The website is under the responsibility of a scientific committee whos... ]
NORD: Wilson's Disease - Offers alternative names, a general discussion and resources.
Meta Description: [ National Organization for Rare Disorders is dedicated to helping people with rare, orphan diseases. Rarediseases.org contains information on the prevention, treatment and cure of rare diseases. ]
Wilson Disease - In-depth look at this disease, its symptoms, the causes, diagnosis and treatment.
Wilson Disease and Menkes Disease - Progress in normal and disordered copper homeostasis, wilson disease, menkes disease, aceruloplasminemia, basic and clinical research. 8th International Conference, April 16 - 18, 2001.
Wilson's Disease - Vanderbilt Medical Center takes an in depth look at this disease. Diagnoses, laboratory studies and treatment are discussed.
Wilson's Disease - A definition of this disease, clinical manifestations, diagnosis and treatment.
Wilson's Disease - Information sheet on this disease compiled by NINDS, the National Institute of Neurological Disorders and Stroke.
Meta Description: [ Wilson's disease information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS). ]
Wilson's Disease - Learn about this disease.
Meta Description: [ Wilson's Disease ]
Wilson's Disease Association - Learn about this disease, about the association, resources for consultation, diagnosis and treatment. Also copper content in various foods.
Meta Description: [ Wilson's Disease Association Inernational ]
Wilson's Disease Association - Information about Wilson's Disease.
Wilsons Disease Support Group UK - Support, outreach and information for people interested in Wilson's disease - an hereditary but treatable disorder caused by defective handling of copper in the body, mainly affecting the liver and brain.
Meta Description: [ Wilson's Disease support group UK aims
to provide patient support, promote education and outreach ]
WilsonsList Support Group - To explore and discuss Wilson's Disease in a friendly manner.
Meta Description: [ WilsonsList: To explore and discuss Wilson's Disease ]
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