Gourt > Health > Conditions and Diseases > Nutrition and Metabolism Disorders > Inherited > Amyloidosis
Amyloids are various types of insoluble fibrous protein aggregations sharing specific traits when examined microscopically. The name amyloid comes from the early mistaken identification of the substance as starch (amylum in Latin), based on crude iodine-staining techniques. For a period, the scientific community debated whether or not amyloid deposits were fatty deposits or carbohydrate deposits until it was finally resolved that it was neither, but rather a deposition of proteinaceous mass.
Amyloid deposits are extracellular, thioflavin-positive, and exhibit apple-green birefringence when stained with congo red when seen under a polarizing microscope. Other indicators exist, such as serum amyloid P component binding. Since these are indirect indicators, biophysicists have redefined amyloid using a canonical set of biophysical characteristics (see below), and this seems to cause a low level of conflict between histologists and biophysicists.
The phenotypes of genetically transmitted amyloid diseases are often inherited in an autosomal dominant fashion. Sometimes, the difference between aggressive amyloid diseases and senescent amyloid diseases is due to a mutation that makes the protein more prone to aggregation. Most commonly seen are point mutations, which affect the cohesiveness of the protein and promote misfolding; other mutations cause aggregation-prone pieces of the protein to be cleaved off from the rest of the protein.
More on [ Amyloid ]
melphalan, bortezomib, & stem cell transplant in treating ppl w/ primary systemic amyloidosis http://bit.ly/5YzQen
localtrials (US Clinical Trials ) Mon, 07 Dec 2009 05:50:56 -0000
melphalan, bortezomib, & stem cell transplant in treating ppl w/ primary systemic amyloidosis http://bit.ly/5YzQen
melphalan, bortezomib, & stem cell transplant in treating ppl w/ primary systemic amyloidosis http://bit.ly/5YzQen
usclinicaltrial (US Clinical Trials) Mon, 07 Dec 2009 05:47:00 -0000
melphalan, bortezomib, & stem cell transplant in treating ppl w/ primary systemic amyloidosis http://bit.ly/5YzQen
melphalan, bortezomib, & stem cell transplant in treating ppl w/ primary systemic amyloidosis http://bit.ly/5YzQen
recruitingtrial (Recruiting Trials) Mon, 07 Dec 2009 04:26:57 -0000
melphalan, bortezomib, & stem cell transplant in treating ppl w/ primary systemic amyloidosis http://bit.ly/5YzQen
collecting samples from ppl w/ primary systemic amyloidosis http://bit.ly/8lOnch
localtrials (US Clinical Trials ) Mon, 07 Dec 2009 02:54:58 -0000
collecting samples from ppl w/ primary systemic amyloidosis http://bit.ly/8lOnch
collecting samples from ppl w/ primary systemic amyloidosis http://bit.ly/8lOnch
usclinicaltrial (US Clinical Trials) Mon, 07 Dec 2009 02:51:02 -0000
collecting samples from ppl w/ primary systemic amyloidosis http://bit.ly/8lOnch
collecting samples from ppl w/ primary systemic amyloidosis http://bit.ly/8lOnch
recruitingtrial (Recruiting Trials) Mon, 07 Dec 2009 01:19:01 -0000
collecting samples from ppl w/ primary systemic amyloidosis http://bit.ly/8lOnch
Amyloidosis Support Network - Provide complete, integrated, easy-to-reach support and information to existing information and referrals for other sources of help. Primarily for patients and their families struggling with the disease.
Meta Description: [ Amyloidosis Support Network - The Network's primary function is to link those affected by amyloidosis, to further support resources, and to educate the public and professionals so that the disease can be recognized earlier and appropriately treated. ]
Amyloid Treatment and Research Center - Contains information about their program, personnel, publications, how to send biopsy material, and how to get to the Boston Medical Center.
Amyloidosis - The Merck Manual: A discussion about amyloid production, the different types of this disease and their signs, symptoms, diagnosis and treatments.
Amyloidosis - Join a support group for this disease and links to other sites.
Amyloidosis - Blood Vessel - A picture of group of proteins arranged in a B-pleated sheet affecting a blood vessel.
Amyloidosis Support Groups - US based, non-profit organization; find out about ASG and its services including newsletters, patient and care giver resources, and fundraising events.
Head and Neck Manifestations of Amyloidosis - Written by J. Cary Moorhead, MD for the Baylor College of Medicine.
Meta Description: [ Head and Neck Manifestations of Amyloidosis, from the Grand Rounds Archive of the Bobby Ray Alford Department of Otolaryngology, Head and Neck Surgery, Baylor College of Medicine. ]
Heart - Amyloidosis - Picture of the heart affected by amyloidosis by the Urbana Atlas of Pathology.
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Immunopathology - Amyloidosis - Detailed information about this disease by Robert C. Mellors, M.D., Ph.D. of the Cornell University Medical College.
Indiana University Amyloid Research and Treatment Center - This site defines amyloidosis and describes current research as well as treatment options. It also introduces the personnel and facilities of the center.
Liver Amyloidosis - A gross specimen of a liver by Urbana Atlas of Pathology.
Long-term AL Primary Amyloidosis - A case study. Some very explicit pictures.
MedicineNet: Amyloidosis - Provides a definition of this condition, symptoms, diagnosis, and treatment.
Meta Description: [ Explains arthritis conditions includes symptoms, causes, medications, and treatment. Written and reviewed by a Rheumatologist. ]
NORD: Amyloidosis - A list of alternative names and a general discussion about this disease.
Meta Description: [ National Organization for Rare Disorders is dedicated to helping people with rare, orphan diseases. Rarediseases.org contains information on the prevention, treatment and cure of rare diseases. ]
Peripheral Neuropathy and Amyloidosis - Ask the doctor medical forum for patients hosted by Med Help.
Meta Description: [ Patient medical question and doctor answer from The Neurology and Neurosurgery Forum. Health topic area and articles about amyloidosis Topics: . ]
Primary Amyloidosis - Mayo Clinic Rochester answers questions on Amyloidosis including what it is, who gets it, what its symptoms are, diagnosis, and treatment.
Meta Description: [ POEMS syndrome treatment options at Mayo Clinic include bone marrow transplants. ]
Symptoms of Amyloidosis - Ask the doctor medical forum for patients hosted by Med Help. A brief look at this disease and the symptoms.
Meta Description: [ Patient medical question and doctor answer from The Neurology and Neurosurgery Forum. Health topic area and articles about amyloidosis Topics: neurological peripheral . ]
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