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Charcot-Marie-Tooth disease, also known as Hereditary Motor and Sensory Neuropathy (HMSN) or Peroneal Muscular Atrophy, is a heterogeneous inherited disorder of nerves (neuropathy) that is characterized by loss of muscle tissue and touch sensation, predominantly in the feet and legs but also in the hands and arms in the advanced stages of disease. Though presently incurable, this disease is one of the most common inherited neurological disorders, with 36 in 100,000 affected (Krajewski et al.,2000).

Description


The disorder is caused by the absence of molecules that are essential for normal function of the nerves due to deficiencies in the structure of the genes coding these molecules. The absence of these chemical substances gives rise to dysfunction either in the axon or the myelin sheath of the nerve cell.

The different classes of this disorder have been divided into the primary demyelinating neuropathies (CMT1, CMT3, and CMT4) and the primary axonal neuropathies (CMT2). Recent studies, however, show that the pathologies of these two classes are frequently intermingled, due to the dependence and close cellular interaction of Schwann cells and neurons. Schwann cells are responsible for myelin formation, enwrapping neural axons with their plama membranes in a process called “myelination” (Berger et al., 2002).

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Charcot-Marie-Tooth Association - Includes information about the organization, its goals, research, news and further resources. Also offers suggestions on ways to help.

Charcot-Marie-Tooth Disorder - Information page compiled by National Institute of Neurological Disorders and Stroke.
Meta Description: [ Charcot-Marie-Tooth Disorder information page compiled by the National Institute of Neurological Disorders and Stroke (NINDS). ]

Charcot-Marie-Tooth Syndrome - Information on this disease: peroneal muscular atrophy or CMT.
Meta Description: [ Informationen ueber eine nicht so seltene, aber kaum bekannte Krankheit: Der neurale Muskelschwund ]

CMTWorld.org - Patient support for Charcot Marie Tooth disease including free access, articles, news, forums, and FAQs.
Meta Description: [ An information web site for the Charcot-Marie-Tooth disease. ]

Dejerine-Sottas - Provides news, links, and a message board about Dejerine-Sottas syndrome, also known as CMT Type 3.
Meta Description: [ News and information about Dejerine-Sottas, a demyelinating disease of the peripheral nerves. ]

General Practice Notebook - Charcot-Marie-Tooth disease - Clinically-oriented information.

MDA Publications - Facts about Charcot-Marie-Tooth disease.

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