Cockayne syndrome (or "Weber-Cockayne syndrome", or "Neill-Dingwall Syndrome") is a rare disorder characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging. Hearing loss and eye abnormalities are other common features, but problems with any or all of the internal organs are possible. Cockayne syndrome is inherited in an autosomal recessive pattern.

Forms of Cockayne syndrome

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• CS Type I, or the “classic form”, is characterized by normal fetal growth with the onset of abnormalities in the first two years of life. Impairment of vision, hearing, and the central and peripheral nervous system progressively degenerate until death in the first or second decade of life.
• CS Type II, otherwise known as connatal CS, involves very little neurological development after birth. Death usually occurs by age 7.
• CS Type III is rare and is characterized by late onset. It is milder than Type I and Type II.
• Xeroderma-pigmentiosum-Cockayne syndrome (XP-CS) occurs when an individual also suffers from Xeroderma pigmentosum, another DNA repair disease. Some symptoms of each disease are expressed.

The condition is also classified genetically as follows:

• (TYPE A)
• (TYPE B)
• (TYPE C)

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We had a great time at the first Share & Care Walk in Fairfax, VA to raise funds for Cockayne Syndrome research - http://bit.ly/oXGCA
dmwilsonh (David Wilson) Sat, 03 Oct 2009 15:53:37 -0000
We had a great time at the first Share & Care Walk in Fairfax, VA to raise funds for Cockayne Syndrome research - http://bit.ly/oXGCA

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