Gourt > Health > Conditions and Diseases > Neurological Disorders > Muscle Diseases > Stiff Person Syndrome
Stiff person syndrome (SPS) (or occasionally, stiff-man syndrome) is a rare neurologic disorder of unknown etiology. SPS was first described by Moersch and Woltman at the Mayo Clinic in 1956 .
Those with the illness experience progressive, fluctuating tonic contractions of all muscles, particularly the axial musculature. An inability to walk and general paralysis quickly follow; death usually occurs six to twelve months after diagnosis.
Treatment is mostly palliative with muscle relaxants such as benzodiazepines, which lose their effectiveness as the illness progresses. Because many patients with SPS have circulating antibodies to glutamic acid decarboxylase, an autoimmune cause the disease has been postulated. In the absence of double-blind, placebo-controlled class A trials to determine treatment efficacy, some authorities recommend humane trials of immunosuppressive therapy, plasmapheresis or intravenous immunoglobulin infusion.
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Spinal Cord
Rare Disorders :: Conditions and Diseases
Stiff person syndrome
michaeljavid (Michael Javid) Mon, 14 Dec 2009 17:59:14 -0000
Stiff person syndrome
MCW HealthLink - An article about Stiff-person syndrome, a rare progressive neurological disorder.
Meta Description: [ Stiff-person syndrome is a rare progressive
neurological disorder characterized by constant painful contractions and spasms of
voluntary muscles, particularly the muscles of the back and upper legs.
]
NORD: Stiff Person Syndrome - Offers synonyms, a general discussion and further resources.
Meta Description: [ National Organization for Rare Disorders is dedicated to helping people with rare, orphan diseases. Rarediseases.org contains information on the prevention, treatment and cure of rare diseases. ]
Stiff-Person Syndrome - Information sheet compiled by National Institute of Neurological Disorders and Stroke.
Meta Description: [ Stiff-person (stiff-man syndrome) information sheet compiled by NINDS. ]
Stiffman Syndrome - Also known as Stiff Person Syndrome or Moersch-Woltman. A rare, progressive neurological disease with symptoms of severe spasm, rigidity and falls. Find information and a personal story.
Meta Description: [ A rare progressive neurological disorder characterized by severe spasm, rigidity, and falls.
I was diagnosed in 1994. ]
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