Gourt > Health > Conditions and Diseases > Neurological Disorders > Muscle Diseases > Myopathies
In medicine, a myopathy is a neuromuscular disease in which the muscle fibers dysfunction for any one of many reasons, resulting in muscular weakness. "Myopathy" simply means disorder ("pathy" from pathology) of muscle ("myo"). This implies that the primary defect is within the muscle, as opposed to the nerves ("neuropathies" or "neurogenic" disorders) or elsewhere (e.g., the brain etc.). Muscle cramps, stiffness, and spasm can also be associated with myopathy.
Classes
Because myopathy is such a general term, there are several classes of myopathy. (ICD-10 codes are provided where available.)
- (G71.0) Dystrophies (or muscular dystrophies) are a subgroup of myopathies characterized by muscle degeneration and regeneration. Clinically, muscular dystrophies are typically progressive, since the muscles' ability to regenerate is eventually lost, leading to progressive weakness, often leading to use of a wheelchair, and eventually death, usually related to respiratory weakness.
- (G71.1) Myotonia
- (G71.2) The congenital myopathies do not show evidence for either a progressive dystrophic process (i.e., muscle death) or inflammation, but instead characteristic microscopic changes are seen in association with reduced contractile ability of the muscles. Among others, different congenital myopathies include:
- (G71.2) nemaline myopathy (characterized by presence of "nemaline rods" in the muscle),
- (G71.2) multi/minicore myopathy (characterized by multiple small "cores" or areas of disruption in the muscle fibers),
- (G71.2) centronuclear myopathy (or myotubular myopathy) (in which the nuclei are abnormally found in the center of the muscle fibers) is a rare muscle wasting disorder that occurs in three forms:
- The most severe form is present at birth, inherited as an X-linked genetic trait, and can cause severe respiratory muscle weakness. This is the form of centronuclear myopathy currently referred to as myotubular myopathy.
- A less severe form of centronuclear myopathy that may present itself at birth or in early childhood progresses slowly and is inherited as an autosomal recessive genetic trait.
- The least severe of the three forms of centronuclear myopathy first appears during the second and third decades of life and is slowly progressive; it is inherited as an autosomal dominant genetic trait.
- (G71.3) Mitochondrial myopathies are due to defects in mitochondria, which provide a critical source of energy for muscle.
- (G72.3) Familial periodic paralysis
- (G72.4) Inflammatory myopathies are caused by problems with the immune system attacking components of the muscle, leading to signs of inflammation in the muscle.
- (G73.6) Metabolic myopathies result from defects in biochemical metabolism that primarily affect muscle
- (G73.6/E74.0) Glycogen storage diseases may affect muscle
- (G73.6/E75) Lipid storage disorder
- (M33.0-M33.1) Dermatomyositis, (M33.2) polymyositis, inclusion body myositis, and related myopathies
- (M61) Myositis ossificans
- (M62.89) Rhabdomyolysis and (R82.1) myoglobinurias
- Common muscle (R25.2) cramps and (M25.6) stiffness, and (R29.0) tetany
Treatments
Because different types of myopathies are caused by many different pathways, there is no single treatment for myopathy. Treatments range from treatment of the symptomes to very specific cause-targeting treatments. Drug therapy, physical therapy, bracing for support, surgery, and even acupuncture are current treatments for a variety of myopathies. More on [ Myopathy ]
Aquabub New A: ---quote--- Congenital myopathies are a group of conditions which cause structural changes in . pbrmkv !
bellinovjtl (Susan Johnsoneld) Thu, 31 Dec 2009 13:28:40 -0000
Aquabub New A: ---quote--- Congenital myopathies are a group of conditions which cause structural changes in . pbrmkv !
BIO-NMD Study: Biomarkers for Collagen VI Myopathies and Duchenne ... http://ff.im/-dvy0q
Duchenne_MD (Duchenne Updates) Tue, 29 Dec 2009 20:17:25 -0000
BIO-NMD Study: Biomarkers for Collagen VI Myopathies and Duchenne ... http://ff.im/-dvy0q
Neuromuscular Home Page - Comprehensive professional resource at Washington University School of Medicine
Meta Description: [ fellowship, muscle, nerve, myopathy, neuropathy, ataxia, cerebellar, spinal, antibody, neuromuscular, dystrophy, pain, hereditary, immune, biopsy, als, motor, sensory, autonomic, ion, channel, trophic, pathology, gm1, mag, sulfatide, toxin, axon, alan pestronk, myositis, spastic, paraplegia, dise... ]
Myotubular Myopathy - British information point for sufferers and their families of these disorders and associated muscle abnormalities.
Meta Description: [ Information Point aimed at raising awareness and for anyone interested in Centronuclear or Myotubular Myopathy; sufferers, families, the medical profession, educators and teachers, British information point for sufferers the families and carers of those with Centronuclear Myopathy, Myotubular Myo... ]
Advancement of Research for Myopathies - A non-profit organization with the primary goal of speeding up bio-medical research on IBM2, the Autosomal Recessive form of Hereditary Inclusion Body Myopathies (HIBM). Includes a message board.
Meta Description: [ HIBM, HEREDITARY INCLUSION BODY MYOPATHY, autosomal recessive, or IBM2, DMRV, Nonaka's Myopathy are a muscle wasting disorders that are common in Iranian & Middle Eastern Jews. DMRV or Nonaka's Myopathy is an allelic disorder with same molecular genetic cause that affects Japanese, Chinese, and p... ]
Familial Desminopathy - Desmin related myopathy is a disorder characterized by accumulation of desmin in the muscle cells. It can be dominantly inherited or occur spontaneously, its effects can range from mild to severe.
Meta Description: [ familial desminopathy, desmin related myopathy ]
Multicore Myopathy - Offers an informational and support site for all myopathies.
Meta Description: [ Multicore/Minicore Myopathy Information and Support Site ]
Myopathy - Information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
Meta Description: [ Myopathy information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS). ]
Myopathy and neuromuscular junction disorders - Detailed information on some of the muscle diseases.
Myotubular Myopathy Resource Group - Information and support for parents and medical professionals about x-linked, autosomal recessive, and autosomal dominant forms of MTM. Includes a web-based discussion group, newsletter, FAQs, articles, tips, current research, and family stories.
Nemaline Myopathy - Information and contacts regarding Nemaline Myopathy
Meta Description: [ Regularly updated personal web for nemaline myopathy. Many useful links. ]
NINDS: Inclusion Body Myositis - Also known as inflammatory myopathy, an information sheet compiled by National Institute of Neurological Disorders and Stroke.
Meta Description: [ Inclusion Body Myositis (Inflammatory Myopathy) information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS). ]
Periodic Paralyses - Information sheet compiled by NINDS, the National Institute of Neurological Disorders and Stroke.
Meta Description: [ Familial Periodic Paralyses information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS). ]
Rhabdomyolysis - Comprehensive information about the medical condition rhabdomyolysis, complete with tables, pictures, and diagrams.
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