Primary progressive aphasia (PPA), also known as Mesulam's Syndrome, is a gradually appearing and gradually worsening disorder of speech that occurs without any major change in other cognitive functions for a period of at least two years. There are three main variants of PPA:

• Progressive nonfluent aphasia
• Logopenic progressive aphasia, and
• Semantic dementia

References

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• Mesulam, MM (2001) "Primary progressive aphasia" Ann Neurol. 49(4):425-32.
• Gorno-Tempini ML, Dronkers NF, Rankin KP, Ogar JM, Phengrasamy L, Rosen HJ, Johnson JK, Weiner MW, Miller BL. (2004) "Cognition and anatomy in three variants of primary progressive aphasia." Ann Neurol. 55(3):335-46.

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85% of Semantic Variant Primary Progressive Aphasia have TDP-43 accumulation. Starting treatment trials in coming years. #ioalecture
PennAging (@PennAging) Sat, 04 Feb 2012 14:16:23 -0000
85% of Semantic Variant Primary Progressive Aphasia have TDP-43 accumulation. Starting treatment trials in coming years. #ioalecture
@DeborahAlsina @Rob_Cares What was he diagnosed with? Mine has Primary Progressive Aphasia a nasty form of dementia taking away speech etc
charbhardy (Charmaine Hardy) Fri, 03 Feb 2012 20:41:36 -0000
@DeborahAlsina @Rob_Cares What was he diagnosed with? Mine has Primary Progressive Aphasia a nasty form of dementia taking away speech etc
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