Gourt > Health > Conditions and Diseases > Neurological Disorders > Congenital Anomalies > Lissencephaly
Lissencephaly, which literally means smooth brain, is a rare brain formation disorder characterized by the lack of normal convolutions (folds) in the brain. It is caused by defective neuronal migration, the process in which nerve cells move from their place of origin to their permanent location. It is a form of cephalic disorder.
The surface of a normal brain is formed by a complex series of folds and grooves. The folds are called gyri or convolutions, and the grooves are called sulci. In children with lissencephaly, the normal convolutions are absent or only partly formed, making the surface of the brain smooth. Terms such as 'agyria' (no gyri) or 'pachygyria' (broad gyri) are used to describe the appearance of the surface of the brain
Symptoms of the disorder may include unusual facial appearance, difficulty swallowing, failure to thrive, and severe psychomotor retardation. Anomalies of the hands, fingers, or toes, muscle spasms, and seizures may also occur.
More on [ Lissencephaly ]
Genetic Disorders
Rare Disorders :: Conditions and Diseases
@LaurenMaeO Gyri= ridges, sulci= wrinkles. Too smooth a brain= lissencephaly, retardation. Too wrinkled a brain= schizophrenia.
kapnkaty (kapnkaty) Thu, 17 Dec 2009 02:27:43 -0000
@LaurenMaeO Gyri= ridges, sulci= wrinkles. Too smooth a brain= lissencephaly, retardation. Too wrinkled a brain= schizophrenia.
The Lissencephaly Network - Information for the parents, siblings, physicians of children born with lissencephaly (smooth brain), and other neuronal migration disorders.
Meta Description: [ This web site is provided for the parents, siblings, physicians and therapists of children born with lissencephaly (smooth brain), and other neuronal migration disorders. ]
Corleen's Page - Personal account of having a daughter with Lissencephaly. Includes a mailing list.
Meta Description: [ Family Support site for children with Lissencephaly smooth brain ]
Lissencephaly Contact Group - UK based support group. Learn about Lissencephaly and which rare brain disorders belong in this group, find a forum and resources.
Meta Description: [ UK based contact group for Lissencephaly. ]
NINDS: Lissencephaly - Information sheet from the National Institute of Neurological Disorders and Stroke.
Meta Description: [ Lissencephaly information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS). ]
The Lissencephaly List - An e-mail based support group for families of children with this disease.
Meta Description: [ lissencephaly: Lissencephaly - smooth brain ]
| Nostalgic Box | |
| Next Video | |
