A congenital disorder is a medical condition that is present at birth. (It is contrasted with the term "acquired disorder") A congenital disorder can be recognized before birth (prenatally), at birth, or many years later. Congenital disorders can be a result of genetic abnormalities, the intrauterine environment, or unknown factors. A congenital condition can arise from the genetic make-up of the fertilized egg or be acquired at any time during fetal development. The causes of many congenital disorders are not known.

Congenital disorders include minor physical anomalies (e.g., a birthmark), severe malformations of single systems (e.g., congenital heart disease or amelia of the legs), and combinations of abnormalities affecting several parts of the body. Defects of metabolism are also considered congenital disorders. A congenital disorder can have trivial or grave effects. The most severe, such as anencephaly, are incompatible with life. Birth defects are a leading cause of death in early infancy, accounting for the deaths of nearly 2 out every 1000 infants (US statistics).

About 2% to 3% of babies are born with significant congenital birth defects. Birth defects involving the brain are the largest group at 10 per 1000 live births), compared to heart at 8 per 1000, kidneys at 4 per 1000, and limbs at 2 per 1000. All other defects have a combined incidence of 6 per 1000 live births. Birth defects of the heart are the most common birth defect leading to death in infancy, accounting for 28% of infant deaths due to birth defects, while chromosomal abnormalities and respiratory abnormalities each account for 15%, and brain defects about 12%.

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National Institutes of Health (NIH) News Releases

Schizophrenia and Bipolar Disorder Share Genetic Roots
Wed, 01 Jul 2009 15:45:00 -0400
A trio of genome-wide studies -- collectively the largest to date -- have pinpointed a vast array of genetic variation that cumulatively may account for at least one third of the genetic risk for schizophrenia. One of the studies traced schizophrenia and bipolar disorder, in part, to the same chromosomal neighborhoods.
Imaging Technique Allows Researchers to Monitor Protein Changes in Mouse Tumors
Wed, 01 Jul 2009 12:05:00 -0400
A new imaging technique can monitor, in living mice, the HER2 protein found in above-normal amounts in many cases of breast cancer as well as some ovarian, prostate and lung cancers. This new approach, once validated in mice and pending further experiments, could provide a real-time noninvasive method for identifying tumors in humans who express HER2 and who would be candidates for targeted therapy directed against this protein. It may also provide real-time information that will help clinicians optimize treatment for individual patients. The study, published in the July 2009 issue of The Journal of Nuclear Medicine, was conducted by researchers at the National Cancer Institute (NCI) and the National Institute of Biomedical Imaging and Bioengineering, both parts of the National Institutes of Health.
Dynasty: Influenza Virus in 1918 and Today
Tue, 30 Jun 2009 09:10:00 -0400
The influenza virus that wreaked worldwide havoc in 1918-1919 founded a viral dynasty that persists to this day, according to scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. In an article published online on June 29 by the New England Journal of Medicine, authors Anthony S. Fauci, M.D., Jeffery K. Taubenberger, M.D., Ph.D., and David M. Morens, M.D., argue that we have lived in an influenza pandemic era since 1918, and they describe how the novel 2009 H1N1 virus now circling the globe is yet another manifestation of this enduring viral family.

CNN.com - Health

Police: Hospital worker swiped shots, spread hep C
Fri, 03 Jul 2009 18:18:42 -0400
A former hospital employee may have exposed hundreds or thousands of surgical patients to hepatitis C when she replaced clean needles filled with the powerful painkiller fentanyl with her own dirty needles filled with saline solution.
Health.com picks top beach, lake getaways
Fri, 03 Jul 2009 13:47:40 -0400
We know your summer vacation time is precious: You want to land where you can truly relax, breathe fresh air, get in some exercise and eat well -- without breaking the bank. That's why we teamed up with a panel of travel and health experts to help us find the healthiest of the nation's most popular beach and lake towns.

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