Mycobacterium is a genus of Actinobacteria, given its own family, the Mycobacteriaceae. It includes many pathogens known to cause serious diseases in mammals, including tuberculosis and leprosy. Most mycobacteria are classified into two categories, the fast-growing kind and the slow-growing kind, and most mycobacteria share some common characteristics:

• They are widespread organisms, typically living in water (including tap water treated with chlorine) and food sources.
• They can colonize their hosts without the hosts showing any adverse signs. For example, millions of people around the world are infected with M. tuberculosis but will never know it because they will not develop symptoms.
• All mycobacteria are aerobic and acid fast. As a genus, they share a characteristic cell wall, thicker than in many other bacteria, hydrophobic, waxy and rich in mycolic acids/mycolates. The mycobacterial cell wall makes a substantial contribution to the hardiness of this genus.
• Mycobacterial infections are notoriously difficult to treat. The organisms are hardy and due to their cell wall, which is neither truly gram negative nor positive and unique to the family, they are naturally resistant to a number of antibiotics that utilize the destruction of cell walls, such as penicillin. Also, because of this cell wall, they can survive long exposure to acids, alkalis, detergents, oxidative bursts, lysis by complement and antibiotics which naturally leads to antibiotic resistance. Most mycobacteria are susceptible to the antibiotics clarithromycin and rifamycin, but antibiotic-resistant strains are known to exist.
• Mycobacteria tend to be fastidious (difficult to culture), sometimes taking over two years to develop in culture. As well as being fastidious, some species also have extremely long reproductive cycles (M. leprae, for example, may take more than 20 days to proceed through one division cycle; E. coli, for comparison, takes only 20 minutes), making laboratory culture a slow process.

Medical classification

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Mycobacteria can be classified into several major groups for purpose of diagnosis and treatment:

• M. tuberculosis complex which can cause tuberculosis: M. tuberculosis, M. bovis, M. africanum, and M. microti
• M. leprae which causes Hansen's disease or leprosy
• Nontuberculous mycobacteria (NTM) are all the other mycobacteria which can cause pulmonary disease resembling tuberculosis, lymphadenitis, skin disease, or disseminated disease.

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Natural lysophospholipids reduce #Mycobacterium tuberculosis-induced #cytotoxicity & induce anti-mycobacterial activity http://bit.ly/8MnziQ
Talulinha (I Andrade) Thu, 10 Dec 2009 23:35:58 -0000
Natural lysophospholipids reduce #Mycobacterium tuberculosis-induced #cytotoxicity & induce anti-mycobacterial activity http://bit.ly/8MnziQ
Wellcome Trust: Protective role of membrane tumour necrosis factor in the host’s resistance to mycobacterial infe... http://bit.ly/8r64uq
UKPubMedCentral (UK PubMed Central) Wed, 09 Dec 2009 01:24:01 -0000
Wellcome Trust: Protective role of membrane tumour necrosis factor in the host’s resistance to mycobacterial infe... http://bit.ly/8r64uq
#t4tb Platensimycin activity against mycobacterial [Rv1180] beta-ketoacyl-ACP synthases.[PMID:19609444]
girishgene07 (Girish M R ) Tue, 08 Dec 2009 10:56:16 -0000
#t4tb Platensimycin activity against mycobacterial [Rv1180] beta-ketoacyl-ACP synthases.[PMID:19609444]
#t4tb Thiolactomycin & related analogues as anti-mycobacterial agents targeting [Rv2245] & [Rv2246] in MTB [PMID:10747933]
girishgene07 (Girish M R ) Tue, 08 Dec 2009 10:54:16 -0000
#t4tb Thiolactomycin & related analogues as anti-mycobacterial agents targeting [Rv2245] & [Rv2246] in MTB [PMID:10747933]
#t4tb antioxidants: catalase-peroxidase, alkylhydroperoxidase C, NADPH quinone reductase [Rv3303c]:mycobacterial virulence[PMID:19436730]
Swetha84 (Swetha Raghavan) Fri, 04 Dec 2009 07:23:57 -0000
#t4tb antioxidants: catalase-peroxidase, alkylhydroperoxidase C, NADPH quinone reductase [Rv3303c]:mycobacterial virulence[PMID:19436730]
#t4tb Analysis of the function of mycobacterial [Rv0352] DnaJ proteins by overexpression and microarray profiling. [PMID:15207487]
girishgene07 (Girish M R ) Thu, 03 Dec 2009 13:07:22 -0000
#t4tb Analysis of the function of mycobacterial [Rv0352] DnaJ proteins by overexpression and microarray profiling. [PMID:15207487]

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