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According to the oral polio vaccine (OPV) AIDS hypothesis, the AIDS pandemic originated from live polio vaccines prepared in chimpanzee tissue cultures (at least some of which were almost certainly contaminated with chimpanzee SIV) which were administered to up to one million Africans between 1957 and 1960. The specific populations, who may not have been properly informed of the risks before volunteering for the vaccination, were the first in the world to experience HIV-1 infections and AIDS some five to twenty years later.

In particular the experimental oral vaccine, called CHAT, is claimed to have been contaminated with simian immunodeficiency virus (SIV), a group of viruses endemic to African primates and widely accepted as the origin of HIV. Recent evidence shows that CHAT may have been concentrated in African facilities using tissue cultures made from chimpanzee kidneys (more importantly, utilizing chimpanzee serum, containing macrophages, the target of immunodefficiency viruses).

Proponents of the OPV AIDS hypothesis include journalist Edward Hooper, as well as scientists Lous Pasteur and the late W.D. Hamilton.

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