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Antiphospholipid syndrome (or antiphospholipid antibody syndrome) is a disorder of coagulation which causes thrombosis in both arteries and veins, as well as recurrent miscarriage. It is due to the autoimmune production of antibodies against cell membrane constituents. It is occasionally referred to as Hughes syndrome after the rheumatologist Dr Graham R.V. Hughes (St. Thomas' Hospital, London, UK) who now works treating Lupus and Hughes Syndrome at the London Lupus Centre.

A very rare form is the catastrophic antiphospholipid syndrome, in which there is rapid organ dysfunction and failure. It carries a high mortality.

Signs and symptoms


The presence of antiphospholipid antibodies (APLAs) is suggested by thrombosis (arterial or venous) and recurrent miscarriage (especially in the second trimester, but often earlier). Other common findings, although not part of the classification, are thrombocytopenia (low platelet count) and livedo reticularis (a skin condition). Many patients report headaches.

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Blood Coagulation Disorders
Thrombosis :: Vascular Disorders
Chronic Illness
Complications Pregnancy and Birth

 
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Rheum: Primary antiphospholipid syndrome with and without Sneddons syndrome: Rheumatology International http://url4.eu/xBuu
MDLinx (Sandeep Pulim MD) Fri, 18 Dec 2009 09:20:33 -0000
Rheum: Primary antiphospholipid syndrome with and without Sneddons syndrome: Rheumatology International http://url4.eu/xBuu
RT @APSFA: Recurrent Miscarriage in Women with and without #Antiphospholipid Syndrome http://bit.ly/8PG1GW #APS
eyzrbrn (Tina Pohlman) Thu, 17 Dec 2009 02:43:18 -0000
RT @APSFA: Recurrent Miscarriage in Women with and without #Antiphospholipid Syndrome http://bit.ly/8PG1GW #APS
RT @APSFA: Antiphospholipid Syndrome: Clinical Characteristics of Patients & Affected Family Members From Multiplex Families http://bit. ...
eyzrbrn (Tina Pohlman) Thu, 17 Dec 2009 02:42:15 -0000
RT @APSFA: Antiphospholipid Syndrome: Clinical Characteristics of Patients & Affected Family Members From Multiplex Families http://bit. ...
RT @APSFA: Current management of #antiphospholipid syndrome-related thrombosis http://bit.ly/6KpeJd #APS
eyzrbrn (Tina Pohlman) Thu, 17 Dec 2009 02:40:21 -0000
RT @APSFA: Current management of #antiphospholipid syndrome-related thrombosis http://bit.ly/6KpeJd #APS
Current management of antiphospholipid syndrome-related thrombosis. http://bit.ly/6KpeJd #APS
APSFA (APSFA) Thu, 17 Dec 2009 02:35:31 -0000
Current management of antiphospholipid syndrome-related thrombosis. http://bit.ly/6KpeJd #APS
Thrombosis of the inferior vena cava revealing primary antiphospholipid syndrome: A case report http://bit.ly/8qc0Nr
APSFA (APSFA) Thu, 17 Dec 2009 02:34:49 -0000
Thrombosis of the inferior vena cava revealing primary antiphospholipid syndrome: A case report http://bit.ly/8qc0Nr

 
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Antiphospholipid Antibody Syndrome - Medical research information on APLS, APS, APLAS or Hughes Syndrome and related blood disorders.
Meta Description: [ Antiphospholipid Syndrome information and help pages for APS patients, doctors and medical professionals, Antiphospholipid Syndrome - Antiphospholipid syndrome (APS) is a disorder characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with typical laboratory abnor... ]

Antiphospholipid Antibody Syndrome on the Net - Features background information, message board, chat room, and related links.
Meta Description: [ Hotdog Express Document ]

500 Antiphospholipid Syndrome Collaborative Registry - A national, NIH-funded, multicenter disease registry that supports a wide range of research into the causes, diagnosis, and treatment of APS. Includes links to enrollment sites.

APS Foundation of America, Inc. - Organization providing education, support, research, patient services and public awareness. Includes FAQ about the disorder.
Meta Description: [ The APS Foundation of America, Inc. is the only United States nonprofit health agency dedicated to bringing national awareness to Antiphospholipid Antibody Syndrome (APS), the major cause of multiple miscarriages, thrombosis, young strokes and heart attacks. This site is volunteer run, community ... ]

MCW Healthlink - An article about antiphospholipid syndrome with a discussion on diagnosis, symptoms and treatment are discussed.
Meta Description: [ Antiphospholipid syndrome is characterized by the clots in the blood vessels, recurrent miscarriages, and a low number of blood platelets. ]

Med Students - A review about antiphospholipid syndrome, giving most importance on its clinical features, diagnosis and management.
Meta Description: [ Antiphospholipid Syndrome: A review giving most importance on its clinical features, diagnosis and management. ]

MedicineNet - A look at antiphospholipid antibody syndrome, what laboratory tests can support the diagnosis of this syndrome, what are the causes and how is it treated.
Meta Description: [ Antiphospholipid syndrome (phospholipid antibody syndrome or Hughes syndrome) is an immune system disorder characterized by excessive blood clotting and/or pregnancy complications (premature miscarriages, unexplained fetal death, or premature birth) and the presence of antiphospholipid antibodies... ]

Neuroland: Antiphospholipid Syndrome - Among the topics discussed are primary and secondary APS, clinical manifestations, treatment and further reading.

NORD: Antiphospholipid Syndrome - Offers a brief discussion with a list of resources for more information.
Meta Description: [ National Organization for Rare Disorders is dedicated to helping people with rare, orphan diseases. Rarediseases.org contains information on the prevention, treatment and cure of rare diseases. ]

The Antiphospholipid Syndrome - By Sara Marder, M.D. An explanation of this order and its association with pregnancy loss, who should be tested and its treatment.

The Hughes Syndrome Foundation - Information about antiphospholipid syndrome, the symptoms, diagnosing and treatment. Also information about the foundation itself.
Meta Description: [ Hughes Syndrome Foundation is based in St Thomas's hospital, London. This site contains information about the charity and about Hughes Syndrome, also known as the antiphospholipid syndrome, for patients, doctors and supporters. ]

500 University of Illinois Patient Resources - Information on Hughe's Syndrome (anthiphospholipid antibody syndrome) including risks of the disease and current treatment options.

University of Michigan Health System - A look at antiphospholipid syndrome and the symptoms, cause of the blood clotting, diagnosis and treatment.
Meta Description: [ Antiphospholipid Syndrome ]

Women's Health - A look at antiphospholipid syndrome, what it is, problems it can cause, if it can be prevented, how common it is, and what to do.
Meta Description: [ An overview of a common test done for women expereincing recurrent miscarriages. Includes information on recommended infertility treatment for those with APS. ]

Yahoo! Groups: Antiphospholipid Syndrome - A mailing list and forum.
Meta Description: [ APLSUK: We are a support group for people who have Hughes Syndrome/ Antiphospholipid Syndrome which is an Auto Immune Disorder ]

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