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IgA nephropathy (also known as IgA nephritis, IgAN, Berger's disease and synpharyngitic glomerulonephritis) is a form of glomerulonephritis (inflammation of the glomeruli of the kidney). This should not be confused with Buerger's disease, an unrelated condition.

IgA nephropathy is the most common glomerulonephritis throughout the world. Primary IgA nephropathy is characterized by deposition of the IgA antibody in the glomerulus. There are other diseases associated with glomerular IgA deposits, the most common being Henoch-Schönlein purpura, which is considered by many to be a systemic form of IgA nephropathy. Henoch-Schönlein purpura presents with a characteristic skin rash, occurs more commonly in children and is associated with a more benign prognosis than IgA nephropathy, which typically presents with hematuria in adults and may lead to chronic renal failure.

Signs and symptoms


The classic presentation (in 40-50% of the cases) is episodic frank hematuria which usually starts within a day of an upper respiratory tract infection (sore throat)(hence syn=together, pharyngitis=sore throat, as opposed to post-streptococcal glomerulonephritis). Flank pain can also occur. The frank hematuria resolves after a few days, though the microscopic hematuria persists. These episodes occur on an irregular basis, and in most patients, this eventually stops (although it can take many years). Renal function usually remains normal, though rarely, acute renal failure may occur(see below). This presentation is more common in younger adults.

A smaller proportion (20-30%), usually the older population, have microscopic hematuria and proteinuria (less than 2 grams of protein per 24 hours). These patients may not have any symptoms and are only picked up if a doctor decides to take a urine sample. Hence, the disease is picked up more commonly in situations where screening of urine is compulsory, e.g. schoolchildren in Japan.

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@ms_hbastes after months of doctors visits, they finally diagnosed me with IgA Nephropathy. I have 2 eat like a rabbit 2 protect my kidneys.
sopheONE (Sophe) Mon, 14 Dec 2009 21:37:58 -0000
@ms_hbastes after months of doctors visits, they finally diagnosed me with IgA Nephropathy. I have 2 eat like a rabbit 2 protect my kidneys.
User Comment: Comment on Proteinuria-Reducing Effects of Tonsillectomy Alone in IgA Nephropathy Re.. http://bit.ly/7U1Lss
nephrologynow (Nephrology Now) Mon, 14 Dec 2009 16:20:55 -0000
User Comment: Comment on Proteinuria-Reducing Effects of Tonsillectomy Alone in IgA Nephropathy Re.. http://bit.ly/7U1Lss
RT @Sciencia: Coccoid Helicobacter pylori exists in the palatine tonsils of patients with IgA nephropathy http://kele.es/nVH
Talulinha (I Andrade) Fri, 11 Dec 2009 07:37:50 -0000
RT @Sciencia: Coccoid Helicobacter pylori exists in the palatine tonsils of patients with IgA nephropathy http://kele.es/nVH
Coccoid Helicobacter pylori exists in the palatine tonsils of patients with IgA nephropathy http://kele.es/nVH
Sciencia (Webmaster Sciencia) Fri, 11 Dec 2009 05:30:49 -0000
Coccoid Helicobacter pylori exists in the palatine tonsils of patients with IgA nephropathy http://kele.es/nVH

 
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Adam. com: An Overview - IgA nephropathy also known as berger's disease, a look at what it is, causes, incidence and risk factors.

404 Australian Kidney Fact Sheet - IgA nephropathy, what it is, diagnosis, causes, the course of the disease, follow up and treatment.

404 IgA Nephropathy - A personal story of Darryl who had this disease. From the beginning, to the diagnosis, the kidney transplant and the update.

Igan Consortium - IgA Nephropathy; protocol for diagnosis, booklet and general project information.

Methodist Health Care System - A description of IgA nephropathy along with a look at the causes, symptoms and treatment.
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404 Outlines in Clinical Medicine - A detailed look at IgA nephropathy, the occurrences and symptoms, pathology and treatment.

Vanderbilt Medical Center - An article about IgA nephropathy.

404 Virtual Hospital - An article written by Donna J. Lager, M.D. about IgA nephropathy.
Meta Description: [ Virtual Hospital was a digital library of health information in pediatrics, paediatrics, and radiology for pediatric education and radiology education ]

Western Queens Dialysis - Causes of IgA nephropathy, written by Ari Kostadaras, MD. Looks at the pathology, presenting symptoms, diagnosis and etiology.
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Yahoo Groups - Information about an IgA Nephropathy patient support group with email list, news and current medical and evidence-based information.
Meta Description: [ iga-nephropathy: IgA Nephropathy Support Group ]

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