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In medicine, hemolytic-uremic syndrome (or haemolytic-uraemic syndrome, abbreviated HUS) is a disease characterised by microangiopathic hemolytic anemia, acute renal failure and a low platelet count (thrombocytopenia).

Signs and symptoms


The classic childhood case of HUS occurs after bloody diarrhea caused by H7, a strain of E. coli that expresses verotoxin (also called Shiga toxin). The toxin enters the bloodstream, attaches to renal endothelium and initiates an inflammatory reaction leading to acute renal failure (ARF) and disseminated intravascular coagulation (DIC). The fibrin mesh destroys red blood cells and captures thrombocytes, leading to a decrease of both on full blood count.

HUS occurs after 2-7% of all E. coli O157:H7 infections.

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Atypical Hemolytic Uremic Syndrome - Atypical HUS, is a rare disease among children causing kidney failure and high blood pressure. Offering support and information including, treatment, symptoms, case studies and research.

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