Gourt > Health > Conditions and Diseases > Genetic Disorders > Hereditary Spastic Paraplegia
Hereditary spastic paraplegia (HSP), also called familial spastic paraparesis (FSP), refers to a group of inherited disorders that are characterized by progressive weakness and stiffness of the legs.
Symptoms
Though the primary feature of HSP is severe, progressive, lower extremity spasticity, in more complicated forms it can be accompanied by other neurological symptoms. These include optic neuropathy, retinopathy (diseases of the retina), dementia, ataxia (lack of muscle control), icthyosis (a skin disorder resulting in dry, rough, scaly skin), mental retardation, peripheral neuropathy, and deafness.
Diagnosis
Diagnosis is primarily by neurological examination and testing to exclude other disorders. Specialized genetic testing and diagnosis are available at some medical centers. More on [ Hereditary spastic paraplegia ]
A novel splicing mutation (c.870+3A>G) in SPG4 in a Korean family with hereditary spastic paraplegia http://kele.es/lfj
Bio_Network (George Maine) Thu, 26 Nov 2009 08:30:54 -0000
A novel splicing mutation (c.870+3A>G) in SPG4 in a Korean family with hereditary spastic paraplegia http://kele.es/lfj
GeneClinics: An Overview - In depth details about hereditary spastic paraplegia. Includes a summary, definition, categories, diagnosis, genetic counseling and resources.
Hereditary Spastic Paraplegia - In depth look at this disease by John K. Fink, M.D., including genetic analysis, clinical features and FAQs.
Hereditary Spastic Paraplegia - HSP information sheet compiled by the National Institute of Neurological Disorders and Stroke.
Meta Description: [ Hereditary Spastic Paraplegia information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS). ]
MCW Healthlink: HSP - An article about hereditary spastic paraplegia, also called familial spastic paralysis.
Meta Description: [ Hereditary spastic paraplegia (HSP), also called familial spastic paralysis, refers to a group of genetic disorders that are characterized by progressive weakness and spasticity (stiffness) of the legs. ]
Spastic Paraplegia Foundation - Supports on the upper motor neuron disorders hereditary spastic paraplegia and primary lateral sclerosis. Information about these conditions, disability resources, newsletters, news, announcements, research and support.
Meta Description: [ Spastic
Paraplegia Foundation (SPF) Home Page. The SPF is responsible for the spread of information involving upper motor neuron disorders called
Hereditary Spastic Paraplegia (HSP) and Primary Lateral Sclerosis (PLS). HSP is also known as
Hereditary Spastic Paraparesis, Familial Spastic Parap... ]
The FSP Support Group - For people suffering from Familial Spastic Paraplegia. Includes a newsletter, discussion forum, links, and contact details.
Meta Description: [ The HSP/ FSP Group is a UK based self-help group for those with Hereditary Spastic Paraplegia, HSP, or Familial Spastic Paraplegia, FSP. The HSP Group provides support for those with Hereditary Spastic Paraplegia (HSP). HSP is also known as Hereditary Spastic Paraparesis, Familial Spastic Parapl... ]
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