Gourt > Health > Conditions and Diseases > Endocrine Disorders > Pancreas > Insulin Resistance
Insulin resistance is the condition in which normal amounts of insulin are inadequate to produce a normal insulin response from fat, muscle and liver cells. Insulin resistance in fat cells results in hydrolysis of stored triglycerides, which elevates free fatty acids in the blood plasma. Insulin resistance in muscle reduces glucose uptake whereas insulin resistance in liver reduces glucose storage, with both effects serving to elevate blood glucose. High plasma levels of insulin and glucose due to insulin resistance often leads to the metabolic syndrome and type 2 diabetes.
Pathophysiology
In patients who use insulin, "insulin resistance" is production of antibodies against insulin that lead to lower-than-expected falls of glucose levels (glycemia) after a given dose of insulin. With the development of human insulin and analogues in the 1980's and the decline in the use of animal insulins (e.g., pork, beef), this type of insulin resistance has become very uncommon.
The most common type of insulin resistance is associated with obesity and metabolic syndrome. This was first described in the 1930's by H.P. (Harry) Himsworth (University College Hospital Medical School, London). He described results of experiments in an article in 1936, entitled, "Diabetes Mellitus: Its differentiation into insulin sensitive and insulin insensitive types." He found that those with diabetes can be differentiated into two types: those in whom injected insulin produces an immediate suppression of hyperglycemia; and those in whom the insulin has little or no effect. Hyperglycemia itself can lead to insulin resistance, but N-acetylcysteine and taurine can prevent this effect.
More on [ Insulin resistance ]
@TheDoctors excuse me Drs,. Sugar does NOT cause #diabetes. A non-producing pancreas and/or insulin resistance causes #diabetes
babscampbell (Barbara Campbell) Wed, 16 Dec 2009 21:33:57 -0000
@TheDoctors excuse me Drs,. Sugar does NOT cause #diabetes. A non-producing pancreas and/or insulin resistance causes #diabetes
Is going to have to wear one of those stupid medical i.d bracelets because Im taking an insulin resistance pill...lame
YoursTrulyNikki (Nikki Bara) Wed, 16 Dec 2009 20:45:46 -0000
Is going to have to wear one of those stupid medical i.d bracelets because Im taking an insulin resistance pill...lame
Diabetes: Novel type 2 diabetes mellitus risk locus near IRS1 is associated with insulin resistance and hyperinsulinemia http://twa.lk/IchiK
Rid_Diabetes (Cure Diabetics) Wed, 16 Dec 2009 18:21:05 -0000
Diabetes: Novel type 2 diabetes mellitus risk locus near IRS1 is associated with insulin resistance and hyperinsulinemia http://twa.lk/IchiK
ZánÄty spouÅ¡tÄÄem diabetu?: RT @sciam: Does Inflammation Trigger Insulin Resistance and Diabetes? http://bit.ly/52wdWD
4josef (Josef Smahel) Wed, 16 Dec 2009 18:14:21 -0000
Záněty spouštěčem diabetu?: RT @sciam: Does Inflammation Trigger Insulin Resistance and Diabetes? http://bit.ly/52wdWD
Does Inflammation Trigger Insulin Resistance and Diabetes?: Scientific American - http://shar.es/aDakx
fbhidy (Brian Hidy) Wed, 16 Dec 2009 18:04:55 -0000
Does Inflammation Trigger Insulin Resistance and Diabetes?: Scientific American - http://shar.es/aDakx
RT @sciam: Does Inflammation Trigger Insulin Resistance and Diabetes? http://bit.ly/52wdWD @myen
DaveBourgeau (Dave Bourgeau) Wed, 16 Dec 2009 18:00:23 -0000
RT @sciam: Does Inflammation Trigger Insulin Resistance and Diabetes? http://bit.ly/52wdWD @myen
Glycemic Index and Glycemic Load - Discusses carbohydrates and blood glucose levels. From The Linus Pauling Institute.
Meta Description: [ Linus Pauling Institute at Oregon State University ]
Insulin and its Metabolic Effects - The beginning article of a four part lecture by Ron Rosedale, MD, discussing the importance of insulin.
Meta Description: [ A lecture by Ron Rosedale, MD, discussing the importance of insulin. This information was presented at Designs for Health Institute's BoulderFest Seminar. ]
Insulin Resistance - Defines what it is and lists symptoms and causes including dietary considerations. From Stanford.
Insulin Resistance and Pre-Diabetes - Provides questions and answers on causes, symptoms, and prevention.
Meta Description: [ Reviews causes and symptoms of insulin resistance, discusses how insulin resistance diagnosis, who is at risk, ways to treat insulin resistance to avoid hyperglycemia and diabetes ]
Insulin Resistance Syndrome - American Academy of Family Physicians descriptive site about this condition. Written for medical professionals; also includes patient handouts.
Optimal Management of Hypertension and Obesity in the Metabolic Syndrome - A continuing medical education monograph on the Metabolic Syndrome, otherwise known as insulin resistance or Syndrome X. In PDF.
Meta Description: [ Metabolic Syndrome Online ]
The Glycemic Index: Flogging a Dead Horse? - Article arguing for the usefulness of the glycemic index.
Treatment of Insulin Resistance - A physician's opinion and recommendations on this topic.
Meta Description: [ Dr. Gabe Mirkin reports on the latest breakthroughs in treatment of diabetes. Read or listen to dozens of reports on diabetes ]
Understanding Insulin Resistance - Describes how insulin resistance can lead to high blood sugar. By GlaxoSmithKline.
Meta Description: [ Insulin is a diabetic medication used to control blood sugar normal levels. ]
Episode Three; The Importance of Insulin Resistance |
