Gourt > Health > Conditions and Diseases > Digestive Disorders > Stomach > Peptic Ulcer > Zollinger Ellison Syndrome
Zollinger-Ellison syndrome is a disorder where increased levels of the hormone gastrin are produced, causing the stomach to produce excess hydrochloric acid. Often, the cause is a tumour of the pancreas producing the hormone gastrin.
Causes
Zollinger-Ellison syndrome is caused by tumors usually found in the head of the pancreas and the upper small bowel (over 90% in the so called gastrinoma triangle, bounded by the porta hepaticus, the neck of the pancreas, and the 2nd part of the duodenum). These tumors produce the hormone gastrin and are called gastrinomas. High levels of gastrin cause overproduction of stomach acid.
Gastrin works on stomach parietal cells causing them to secrete more hydrogen ions into the stomach lumen. In addition, gastrin acts as a trophic factor for parietal cells, causing parietal cell hyperplasia. Thus, there is an increase in the number of acid secreting cells and each of these cells produces acid at a higher rate. The increase in acidity contributes to the development of peptic ulcers in the stomach and duodenum. High acid levels lead to multiple ulcers in the stomach and small bowel.
More on [ Zollinger-Ellison syndrome ]
Rare Disorders :: Conditions and Diseases
Case Report: Zollinger-Ellison syndrome associated with neurofibromatosis type 1 http://ow.ly/PdrL
VeoMed (VeoMed Team) Thu, 24 Dec 2009 17:06:15 -0000
Case Report: Zollinger-Ellison syndrome associated with neurofibromatosis type 1 http://ow.ly/PdrL
Case Report: Zollinger-Ellison syndrome associated with neurofibromatosis type 1 http://ow.ly/OQAL
VeoMed (VeoMed Team) Wed, 23 Dec 2009 20:05:59 -0000
Case Report: Zollinger-Ellison syndrome associated with neurofibromatosis type 1 http://ow.ly/OQAL
Zollinger-Ellison syndrome associated with neurofibromatosis type 1: a case report http://ow.ly/OEju
VeoMed (VeoMed Team) Tue, 22 Dec 2009 18:14:59 -0000
Zollinger-Elli
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NORD: Zollinger Ellison Syndrome - A list of alternate names, a general discussion and resources.
Meta Description: [ National Organization for Rare Disorders is dedicated to helping people with rare, orphan diseases. Rarediseases.org contains information on the prevention, treatment and cure of rare diseases. ]
Zollinger-Ellison Syndrome - Rare disorder that causes tumors in the pancreas and duodenum and ulcers in the stomach and duodenum.
Meta Description: [ Zollinger-Ellison Syndrome ]
Zollinger-Ellison Syndrome - A case study of a 62 year old white male by Annick Van den Abbeele, MD and Ruth Hardoff, MD.
