Viral Diseases

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Hepatitis: HBV infection increases risk of pancreatic cancer
Tue, 17 Jan 2012 00:00:00 -0000
A large, case–control study conducted in China has shown that HBV infection increases the risk of pancreatic ductal adenocarcinoma (PDAC). Qiwen et al. assessed hepatitis B status in 943 patients with confirmed PDAC and 1,128 matched controls. Individuals with chronic HBV infection (positive
Screening for tuberculosis and hepatitis B prior to the initiation of anti-tumor necrosis therapy
Mon, 26 Sep 2011 09:46:46 -0000
Background:Since the introduction of infliximab, anti-tumor necrosis factor alpha (anti-TNF-α) agents have been used with increasing frequency for the treatment of inflammatory bowel disease (IBD). Reactivation of latent Mycobacterium tuberculosis (TB) soon became recognized as a complication of therapy. More recently, reactivation of hepatitis B while on anti-TNF therapy has been documented. The aim of this study was to assess the adherence to screening for latent TB and hepatitis B by gastroenterologists prior to initiation of an anti-TNF.Methods:This is a retrospective analysis of all patients with IBD treated with an anti-TNF at a large urban academic hospital. In our population, 65% of patients were screened for latent TB prior to the initiation of anti-TNF therapy, while 25% of patients were screened for hepatitis B.Results:Failure to screen for latent TB was strongly correlated with prior exposure to an anti-TNF (odds ratio [OR]: 5.3; P < 0.0001) and initiation of treatment prior to 2006 (OR: 5.8; P < 0.0001). Failure to screen for hepatitis B was associated with lack of an abnormal alanine aminotransferase (OR: 2.6; P = 0.005) and treatment prior to 2010 (OR: 3.3; P = 0.02). Providers who had been in practice longer were less likely screen for TB or hepatitis B.Conclusions:The rate of screening for both latent TB and hepatitis B in this study was inadequate. While the rate of screening is increasing, further systems improvements and physician education is needed. (Inflamm Bowel Dis 2011;)
No association between IRF3 polymorphism and susceptibility to hepatitis B virus infection in Chinese patients.
Yan F, Gao YF, Lv F, Zhang TC, Li X, Yin HF No association between IRF3 polymorphism and susceptibility to hepatitis B virus infection in Chinese patients. World J Gastroenterol. 2012 Jan 28;18(4):388-92 Authors: Yan F, Gao YF, Lv F, Zhang TC, Li X, Yin HF Abstract AIM: To investigate the association between three tag single nucleotide polymorphisms (tagSNPs) in interferon regulatory factors (IRF3) and the genetic susceptibility to chronic hepatitis B virus (HBV) infection. METHODS: We performed a case-control study of 985 Chinese cases of chronic HBV infection and 294 self-limiting HBV-infected individuals as controls. Three tagSNPs in IRF3 (rs10415576, rs2304204, rs2304206) were genotyped with the Multiplex SNaPshot technique. The genotype and allele frequencies were calculated and analyzed. RESULTS: The three SNPs showed no significant genotype/allele associations with chronic HBV infection. Overall allele P values were: rs10415576, P = 0.0908, odds ratio (OR) [95% confidence interval (CI)] = 1.1798 (0.9740-1.4291); rs2304204, P = 0.5959, OR (95% CI) = 1.0597 (0.8552-1.3133); rs2304206, P = 0.8372, OR (95% CI) = 1.0250 (0.8097-1.2976). Overall genotype P values were: rs10415576, P = 0.2106; rs2304204, P = 0.8458; rs2304206, P = 0.8315. There were no statistically significant differences between patients with chronic HBV infection and controls. Haplotypes generated by these three SNPs were also not significantly different between the two groups. CONCLUSION: The three tagSNPs of IRF3 are not associated with HBV infection in the Han Chinese population. PMID: 22294846 [PubMed - in process]

 

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Acute Viral Hepatitis - Medical information about causes, symptoms, diagnosis, complications, treatment, and prevention of suddenly-occuring inflammation of the liver.

Alcoholic Hepatitis - Discusses the symptoms, treatment, and complications of this liver disease caused by alcohol poisoning.

American Liver Foundation: Getting Hip to Hep - Article explaining how each type is transmitted, risk factors, symptoms, testing, and prevention.

Autoimmune Hepatitis - Discusses liver function, causes of this condition, how it is diagnosed, who is likely to develop it, and treatment to curb the autoimmune response.
Meta Description: [ Jackson Gastroenterology's Web Site includes office information and paient education material on digestive and liver disorders, and nutrition. Endoscopic procedures that help in diagnosis and treatment are also described. ]

Autoimmune Hepatitis - Provides information on the triggers, symptoms, diagnosis, treatment, and complications.
Meta Description: [ Provides information on the triggers, symptoms, diagnosis, treatment, and complications of autoimmune hepatitis. Includes a list of additional resources ]

Chronic Hepatitis - Textbook section provides causes, symptoms, diagnosis and treatment of liver inflammation lasting more than six months.

GayHealth: Hepatitis Resource Center - Information about safe sexual practices, immunization against types A and B, and a risk quiz.
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Hepatitis - Learn about symptoms, transmission, prevention, and treatment options for hepatitis A-E and toxic hepatitis. Includes a comparison chart and quiz. [Message board requires free registration.]
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Hepatitis A-Z - Daniel Dimitriou's site providing extensive information about this disease, including support for spouses of sufferers.

Hepatitis Activist - Help fight liver disease by e-mailing Congress with an automated congressional E-mailer (ACE) system. Also join a list to be kept up to date with liver disease.
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Hepatitis Central - Current information on this disease as well as liver disease, cirrhosis, rebetron and interferon. For the medical professional and patient. Online support groups and patient referred physicians.
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Hepatitis Doctor - Discusses hepatitis B and C, interferon treatments, HCV in veterans and prisoners, and effectiveness of maintenance dosage in non-responsive patients.

Hepatitis Magazine Online - Online version for Hepatitis B and C sufferers. Read sample articles, news briefs and personal stories. Subscription links.

404 Hepatitis Magazine: Open Wide - Explains how hepatitis can affect dental health, potential issues, and talking to the dentist about the disease and medications.

Hepatitis Resource Center - Includes chat, information and articles, newsgroups and message boards, books, related web sites, and medical directories on this disease.
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HepQuest - Hepatitis related information for patients and medical professionals.
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LGBT Health Channel - Contains information and statistics about viral hepatitis.
Meta Description: [ Viral hepatitis is an inflammatory disorder of the liver caused by a virus that can be transmitted through unsafe sex, through feces or bodily fluid, through contaminated food and water, from undercooked shellfish, by using contaminated intravenous drug needles, and through birth. Symptoms inclu... ]

Liver Study Unit, University of Chicago - Provides information about hepatitis for patients, medical students, and physicians.
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MedlinePlus: Hepatitis - Directory of news, articles, and factsheets.
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Viral Hepatitis - Brief description of hepatitis A-E, includes links to detailed information.

Viral Hepatitis: A Through E and Beyond - Explains general symptoms, as well as risk factors, disease spread, prevention, and treatment for each type of virus.
Meta Description: [ Provides information on the symptoms, modes of transmission, at-risk populations, prevention, and treatment for hepatitis A through E. Includes a list of additional resources ]