Gourt > Health > Conditions and Diseases > Cancer > Musculoskeletal > Soft Tissue Sarcoma > Primitive Neuroectodermal Tumor
Ewing's sarcoma is the common name for primitive neuroectodermal tumor. It is a rare disease in which cancer cells are found in the bone or in soft tissue. The most common areas in which it occurs are the pelvis, the femur, the humerus, and the ribs. James Ewing (1866-1943) first described the tumor, establishing that the disease was separate from lymphoma and other types of cancer known at that time. Ewing's sarcoma occurs most frequently in male teenagers, such as Brandon Russell. Ewing's sarcoma is the result of a translocation between chromosomes 11 and 22, which fuses the EWS gene of chromosome 22 to the FLI1 gene of chromosome 11.
Clinical Findings
Ewing's sarcoma is more common in males and usually presents in childhood or early adulthood, with a peak between 10 and 20 years of age. It can occur anywhere in the body, but most commonly in the pelvis and proximal long tubular bones. The diaphysis of the femur are the most common sites, followed by the tibia and the humerus. Thirty percent are overtly metastatic at presentation.The most common clinical findings are pain and swelling.
More on [ Ewing's sarcoma ]
eMedicine: Primitive Neuroectodermal Tumors of the Central Nervous System - Article by Subrata Ghosh, MD describing the disease, statistics, treatment, lab studies, medication, images, and bibliography links.
Meta Description: [ Primitive Neuroectodermal Tumors of the Central Nervous System - Primitive neuroectodermal tumors (PNET) are neoplasms of which medulloblastoma is the prototype. These are small cell, malignant embryonal tumors showing divergent differentiation of variable degree along neuronal, glial, or rarely ... ]
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PNET (Primitive Neuroectodermal Tumor) - Rare family of tumors. Provides information about symtoms, diagnosis, and treatment.
